Analysis of Phytonutrients, Anti-Mutagenic and Chemopreventive Effects of Tropical Fruit Extracts

Thailand is located in the tropics and a wide variety of fruits are grown commercially. However, studies regarding the phytonutrients, anti-mutagenic and chemopreventive effects of these fruits are limited. Thus, phytochemical profiles and inhibition of key enzymes involved in obesity and diabetes,...

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Autores principales:	Piya Temviriyanukul, Suwapat Kittibunchakul, Piyapat Trisonthi, Woorawee Inthachat, Dalad Siriwan, Uthaiwan Suttisansanee
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	antioxidant chemoprevention fruits <i>Mangifera indica</i> mutagenicity phytochemicals Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/911c18de03f84a77a839004ca0965664
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spelling	oai:doaj.org-article:911c18de03f84a77a839004ca09656642021-11-25T17:33:14ZAnalysis of Phytonutrients, Anti-Mutagenic and Chemopreventive Effects of Tropical Fruit Extracts10.3390/foods101126002304-8158https://doaj.org/article/911c18de03f84a77a839004ca09656642021-10-01T00:00:00Zhttps://www.mdpi.com/2304-8158/10/11/2600https://doaj.org/toc/2304-8158Thailand is located in the tropics and a wide variety of fruits are grown commercially. However, studies regarding the phytonutrients, anti-mutagenic and chemopreventive effects of these fruits are limited. Thus, phytochemical profiles and inhibition of key enzymes involved in obesity and diabetes, together with anti-mutagenic and chemopreventive properties of eight tropical fruit extracts cultivated in Thailand, including <i>Psidium guajava</i> ‘Kimju’, <i>Psidium guajava</i> ‘Keenok’, <i>Ananas comosus</i> ‘Pattavia’, <i>Ananas comosus</i> ‘Phulae’, <i>Durio zibethinus</i> ‘Chanee’, <i>Durio zibethinus</i> ‘Monthong’, <i>Carica papaya</i> ‘Khaekdum’ and <i>Mangifera indica</i> ‘Namdokmai’ were investigated. Different cultivars were also compared. Results showed that <i>M. indica</i> ‘Namdokmai’ was the most antioxidant-rich extract containing abundant 4-hydroxybenzoic acid and its derivative, gallic acid, as the main phenolics. <i>M. indica</i> ‘Namdokmai’ also exhibited high inhibitory capacities (>60% inhibition under studied conditions) against lipase, α-amylase and α-glucosidase, key enzymes as drug targets for controlling obesity and type 2 diabetes. Interestingly, all fruit extracts suppressed food mutagen-induced DNA mutations assayed by the Ames test, especially <i>M. indica</i> ‘Namdokmai’ and <i>C. papaya</i> ‘Khaekdum’ (>50% inhibition at 200 µg/plate). The <i>M. indica</i> ‘Namdokmai’ was also the most potent extract for suppression of cancer promotion (>90% inhibition at 200 µg/mL) followed by <i>P. guajava</i> ‘Kimju’, <i>P. guajava</i> ‘Keenok’ and <i>C. papaya</i> ‘Khaekdum’. Results potentially indicated that fruit intake after overcooked meat consumption might supplement nutrients and fiber and also reduce DNA mutation sources.Piya TemviriyanukulSuwapat KittibunchakulPiyapat TrisonthiWoorawee InthachatDalad SiriwanUthaiwan SuttisansaneeMDPI AGarticleantioxidantchemopreventionfruits<i>Mangifera indica</i>mutagenicityphytochemicalsChemical technologyTP1-1185ENFoods, Vol 10, Iss 2600, p 2600 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antioxidant chemoprevention fruits <i>Mangifera indica</i> mutagenicity phytochemicals Chemical technology TP1-1185
spellingShingle	antioxidant chemoprevention fruits <i>Mangifera indica</i> mutagenicity phytochemicals Chemical technology TP1-1185 Piya Temviriyanukul Suwapat Kittibunchakul Piyapat Trisonthi Woorawee Inthachat Dalad Siriwan Uthaiwan Suttisansanee Analysis of Phytonutrients, Anti-Mutagenic and Chemopreventive Effects of Tropical Fruit Extracts
description	Thailand is located in the tropics and a wide variety of fruits are grown commercially. However, studies regarding the phytonutrients, anti-mutagenic and chemopreventive effects of these fruits are limited. Thus, phytochemical profiles and inhibition of key enzymes involved in obesity and diabetes, together with anti-mutagenic and chemopreventive properties of eight tropical fruit extracts cultivated in Thailand, including <i>Psidium guajava</i> ‘Kimju’, <i>Psidium guajava</i> ‘Keenok’, <i>Ananas comosus</i> ‘Pattavia’, <i>Ananas comosus</i> ‘Phulae’, <i>Durio zibethinus</i> ‘Chanee’, <i>Durio zibethinus</i> ‘Monthong’, <i>Carica papaya</i> ‘Khaekdum’ and <i>Mangifera indica</i> ‘Namdokmai’ were investigated. Different cultivars were also compared. Results showed that <i>M. indica</i> ‘Namdokmai’ was the most antioxidant-rich extract containing abundant 4-hydroxybenzoic acid and its derivative, gallic acid, as the main phenolics. <i>M. indica</i> ‘Namdokmai’ also exhibited high inhibitory capacities (>60% inhibition under studied conditions) against lipase, α-amylase and α-glucosidase, key enzymes as drug targets for controlling obesity and type 2 diabetes. Interestingly, all fruit extracts suppressed food mutagen-induced DNA mutations assayed by the Ames test, especially <i>M. indica</i> ‘Namdokmai’ and <i>C. papaya</i> ‘Khaekdum’ (>50% inhibition at 200 µg/plate). The <i>M. indica</i> ‘Namdokmai’ was also the most potent extract for suppression of cancer promotion (>90% inhibition at 200 µg/mL) followed by <i>P. guajava</i> ‘Kimju’, <i>P. guajava</i> ‘Keenok’ and <i>C. papaya</i> ‘Khaekdum’. Results potentially indicated that fruit intake after overcooked meat consumption might supplement nutrients and fiber and also reduce DNA mutation sources.
format	article
author	Piya Temviriyanukul Suwapat Kittibunchakul Piyapat Trisonthi Woorawee Inthachat Dalad Siriwan Uthaiwan Suttisansanee
author_facet	Piya Temviriyanukul Suwapat Kittibunchakul Piyapat Trisonthi Woorawee Inthachat Dalad Siriwan Uthaiwan Suttisansanee
author_sort	Piya Temviriyanukul
title	Analysis of Phytonutrients, Anti-Mutagenic and Chemopreventive Effects of Tropical Fruit Extracts
title_short	Analysis of Phytonutrients, Anti-Mutagenic and Chemopreventive Effects of Tropical Fruit Extracts
title_full	Analysis of Phytonutrients, Anti-Mutagenic and Chemopreventive Effects of Tropical Fruit Extracts
title_fullStr	Analysis of Phytonutrients, Anti-Mutagenic and Chemopreventive Effects of Tropical Fruit Extracts
title_full_unstemmed	Analysis of Phytonutrients, Anti-Mutagenic and Chemopreventive Effects of Tropical Fruit Extracts
title_sort	analysis of phytonutrients, anti-mutagenic and chemopreventive effects of tropical fruit extracts
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/911c18de03f84a77a839004ca0965664
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Analysis of Phytonutrients, Anti-Mutagenic and Chemopreventive Effects of Tropical Fruit Extracts

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