Concurrent Onset of Chronic Lymphocytic Leukemia and Atypical Phenotype Acute Myeloid Leukemia Revealed by Autopsy

The concurrent onset of chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML) is rare, and no autopsy case has been reported. We report herein the first case of concurrent-onset CLL and AML with an atypical phenotype revealed by autopsy. Notably, the diagnosis of AML was quite difficul...

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Autores principales:	Sayaka Kiso, Hiroyuki Sugiura, Taiga Kuroi, Rika Omote, Tomohiro Toji, Tatsunori Ishikawa, Sachiyo Okamoto, Naho Nomura, Taro Masunari, Nobuo Sezaki, Toru Kiguchi, Mitsune Tanimoto
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	chronic lymphocytic leukemia acute myeloid leukemia autopsy flow cytometry immunohistochemical staining Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/911c674abc774f718300cb43ef1a1383
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spelling	oai:doaj.org-article:911c674abc774f718300cb43ef1a13832021-12-02T12:40:23ZConcurrent Onset of Chronic Lymphocytic Leukemia and Atypical Phenotype Acute Myeloid Leukemia Revealed by Autopsy1662-657510.1159/000520427https://doaj.org/article/911c674abc774f718300cb43ef1a13832021-11-01T00:00:00Zhttps://www.karger.com/Article/FullText/520427https://doaj.org/toc/1662-6575The concurrent onset of chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML) is rare, and no autopsy case has been reported. We report herein the first case of concurrent-onset CLL and AML with an atypical phenotype revealed by autopsy. Notably, the diagnosis of AML was quite difficult during the patient’s lifetime because of the atypical phenotype. However, autopsy revealed that the patient’s bone marrow, liver, and spleen were filled with myeloblasts. In addition, p53 stain and PCR of IgH rearrangement using the autopsy specimen suggested that CLL and AML might be different clones. In conclusion, our case highlights the importance of considering synchronous complications of AML in CLL patients, particularly in those with an atypical clinical course.Sayaka KisoHiroyuki SugiuraTaiga KuroiRika OmoteTomohiro TojiTatsunori IshikawaSachiyo OkamotoNaho NomuraTaro MasunariNobuo SezakiToru KiguchiMitsune TanimotoKarger Publishersarticlechronic lymphocytic leukemiaacute myeloid leukemiaautopsyflow cytometryimmunohistochemical stainingNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCase Reports in Oncology, Vol 14, Iss 3, Pp 1725-1732 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chronic lymphocytic leukemia acute myeloid leukemia autopsy flow cytometry immunohistochemical staining Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	chronic lymphocytic leukemia acute myeloid leukemia autopsy flow cytometry immunohistochemical staining Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Sayaka Kiso Hiroyuki Sugiura Taiga Kuroi Rika Omote Tomohiro Toji Tatsunori Ishikawa Sachiyo Okamoto Naho Nomura Taro Masunari Nobuo Sezaki Toru Kiguchi Mitsune Tanimoto Concurrent Onset of Chronic Lymphocytic Leukemia and Atypical Phenotype Acute Myeloid Leukemia Revealed by Autopsy
description	The concurrent onset of chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML) is rare, and no autopsy case has been reported. We report herein the first case of concurrent-onset CLL and AML with an atypical phenotype revealed by autopsy. Notably, the diagnosis of AML was quite difficult during the patient’s lifetime because of the atypical phenotype. However, autopsy revealed that the patient’s bone marrow, liver, and spleen were filled with myeloblasts. In addition, p53 stain and PCR of IgH rearrangement using the autopsy specimen suggested that CLL and AML might be different clones. In conclusion, our case highlights the importance of considering synchronous complications of AML in CLL patients, particularly in those with an atypical clinical course.
format	article
author	Sayaka Kiso Hiroyuki Sugiura Taiga Kuroi Rika Omote Tomohiro Toji Tatsunori Ishikawa Sachiyo Okamoto Naho Nomura Taro Masunari Nobuo Sezaki Toru Kiguchi Mitsune Tanimoto
author_facet	Sayaka Kiso Hiroyuki Sugiura Taiga Kuroi Rika Omote Tomohiro Toji Tatsunori Ishikawa Sachiyo Okamoto Naho Nomura Taro Masunari Nobuo Sezaki Toru Kiguchi Mitsune Tanimoto
author_sort	Sayaka Kiso
title	Concurrent Onset of Chronic Lymphocytic Leukemia and Atypical Phenotype Acute Myeloid Leukemia Revealed by Autopsy
title_short	Concurrent Onset of Chronic Lymphocytic Leukemia and Atypical Phenotype Acute Myeloid Leukemia Revealed by Autopsy
title_full	Concurrent Onset of Chronic Lymphocytic Leukemia and Atypical Phenotype Acute Myeloid Leukemia Revealed by Autopsy
title_fullStr	Concurrent Onset of Chronic Lymphocytic Leukemia and Atypical Phenotype Acute Myeloid Leukemia Revealed by Autopsy
title_full_unstemmed	Concurrent Onset of Chronic Lymphocytic Leukemia and Atypical Phenotype Acute Myeloid Leukemia Revealed by Autopsy
title_sort	concurrent onset of chronic lymphocytic leukemia and atypical phenotype acute myeloid leukemia revealed by autopsy
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/911c674abc774f718300cb43ef1a1383
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Concurrent Onset of Chronic Lymphocytic Leukemia and Atypical Phenotype Acute Myeloid Leukemia Revealed by Autopsy

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