Supramolecular polymer-based transformable material for reversible PEGylation of protein drugs

We herein developed a transformable mixing-type material for reversible PEGylation of protein drugs using a supramolecular backbone polymer, that is, polyrotaxane possessing both amino groups and PEG chains (PEG–NH2–PRX). We expected that PEG–NH2–PRX provides amino groups to interact with protein dr...

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Autores principales:	Kosei Utatsu, Tetsuya Kogo, Toru Taharabaru, Risako Onodera, Keiichi Motoyama, Taishi Higashi
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Polyrotaxane Polyethylene glycol Supramolecular material Protein Pharmaceutical property Medicine (General) R5-920 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/911dbd1679654855943e1bb04ad5934c
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spelling	oai:doaj.org-article:911dbd1679654855943e1bb04ad5934c2021-11-18T04:51:18ZSupramolecular polymer-based transformable material for reversible PEGylation of protein drugs2590-006410.1016/j.mtbio.2021.100160https://doaj.org/article/911dbd1679654855943e1bb04ad5934c2021-09-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2590006421000685https://doaj.org/toc/2590-0064We herein developed a transformable mixing-type material for reversible PEGylation of protein drugs using a supramolecular backbone polymer, that is, polyrotaxane possessing both amino groups and PEG chains (PEG–NH2–PRX). We expected that PEG–NH2–PRX provides amino groups to interact with protein drugs on demand because the mobility of amino groups in PEG–NH2–PRX was high. In fact, PEG–NH2–PRX formed complexes with protein drugs efficiently compared to PEGylated amino-dextran (PEG–NH2–DEX), a control material fabricated with a macromolecular backbone polymer. Moreover, PEG–NH2–PRX markedly improved the stability of antibodies and prolonged the hypoglycemic effects of insulin without loss of bioactivity, compared to PEG–NH2–DEX. These findings suggest that the supramolecular material, PEG–NH2–PRX, is a promising reversible PEGylation material for protein drugs compared to macromolecular materials.Kosei UtatsuTetsuya KogoToru TaharabaruRisako OnoderaKeiichi MotoyamaTaishi HigashiElsevierarticlePolyrotaxanePolyethylene glycolSupramolecular materialProteinPharmaceutical propertyMedicine (General)R5-920Biology (General)QH301-705.5ENMaterials Today Bio, Vol 12, Iss , Pp 100160- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Polyrotaxane Polyethylene glycol Supramolecular material Protein Pharmaceutical property Medicine (General) R5-920 Biology (General) QH301-705.5
spellingShingle	Polyrotaxane Polyethylene glycol Supramolecular material Protein Pharmaceutical property Medicine (General) R5-920 Biology (General) QH301-705.5 Kosei Utatsu Tetsuya Kogo Toru Taharabaru Risako Onodera Keiichi Motoyama Taishi Higashi Supramolecular polymer-based transformable material for reversible PEGylation of protein drugs
description	We herein developed a transformable mixing-type material for reversible PEGylation of protein drugs using a supramolecular backbone polymer, that is, polyrotaxane possessing both amino groups and PEG chains (PEG–NH2–PRX). We expected that PEG–NH2–PRX provides amino groups to interact with protein drugs on demand because the mobility of amino groups in PEG–NH2–PRX was high. In fact, PEG–NH2–PRX formed complexes with protein drugs efficiently compared to PEGylated amino-dextran (PEG–NH2–DEX), a control material fabricated with a macromolecular backbone polymer. Moreover, PEG–NH2–PRX markedly improved the stability of antibodies and prolonged the hypoglycemic effects of insulin without loss of bioactivity, compared to PEG–NH2–DEX. These findings suggest that the supramolecular material, PEG–NH2–PRX, is a promising reversible PEGylation material for protein drugs compared to macromolecular materials.
format	article
author	Kosei Utatsu Tetsuya Kogo Toru Taharabaru Risako Onodera Keiichi Motoyama Taishi Higashi
author_facet	Kosei Utatsu Tetsuya Kogo Toru Taharabaru Risako Onodera Keiichi Motoyama Taishi Higashi
author_sort	Kosei Utatsu
title	Supramolecular polymer-based transformable material for reversible PEGylation of protein drugs
title_short	Supramolecular polymer-based transformable material for reversible PEGylation of protein drugs
title_full	Supramolecular polymer-based transformable material for reversible PEGylation of protein drugs
title_fullStr	Supramolecular polymer-based transformable material for reversible PEGylation of protein drugs
title_full_unstemmed	Supramolecular polymer-based transformable material for reversible PEGylation of protein drugs
title_sort	supramolecular polymer-based transformable material for reversible pegylation of protein drugs
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/911dbd1679654855943e1bb04ad5934c
work_keys_str_mv	AT koseiutatsu supramolecularpolymerbasedtransformablematerialforreversiblepegylationofproteindrugs AT tetsuyakogo supramolecularpolymerbasedtransformablematerialforreversiblepegylationofproteindrugs AT torutaharabaru supramolecularpolymerbasedtransformablematerialforreversiblepegylationofproteindrugs AT risakoonodera supramolecularpolymerbasedtransformablematerialforreversiblepegylationofproteindrugs AT keiichimotoyama supramolecularpolymerbasedtransformablematerialforreversiblepegylationofproteindrugs AT taishihigashi supramolecularpolymerbasedtransformablematerialforreversiblepegylationofproteindrugs
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Supramolecular polymer-based transformable material for reversible PEGylation of protein drugs

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