Supramolecular polymer-based transformable material for reversible PEGylation of protein drugs

We herein developed a transformable mixing-type material for reversible PEGylation of protein drugs using a supramolecular backbone polymer, that is, polyrotaxane possessing both amino groups and PEG chains (PEG–NH2–PRX). We expected that PEG–NH2–PRX provides amino groups to interact with protein dr...

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Autores principales: Kosei Utatsu, Tetsuya Kogo, Toru Taharabaru, Risako Onodera, Keiichi Motoyama, Taishi Higashi
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
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Acceso en línea:https://doaj.org/article/911dbd1679654855943e1bb04ad5934c
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