Yersinia pestis DNA from skeletal remains from the 6(th) century AD reveals insights into Justinianic Plague.

Yersinia pestis, the etiologic agent of the disease plague, has been implicated in three historical pandemics. These include the third pandemic of the 19(th) and 20(th) centuries, during which plague was spread around the world, and the second pandemic of the 14(th)-17(th) centuries, which included...

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Autores principales:	Michaela Harbeck, Lisa Seifert, Stephanie Hänsch, David M Wagner, Dawn Birdsell, Katy L Parise, Ingrid Wiechmann, Gisela Grupe, Astrid Thomas, Paul Keim, Lothar Zöller, Barbara Bramanti, Julia M Riehm, Holger C Scholz
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/91250c94b6804f5ebedbf3569f5f2bf5
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spelling	oai:doaj.org-article:91250c94b6804f5ebedbf3569f5f2bf52021-11-18T06:05:41ZYersinia pestis DNA from skeletal remains from the 6(th) century AD reveals insights into Justinianic Plague.1553-73661553-737410.1371/journal.ppat.1003349https://doaj.org/article/91250c94b6804f5ebedbf3569f5f2bf52013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23658525/pdf/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Yersinia pestis, the etiologic agent of the disease plague, has been implicated in three historical pandemics. These include the third pandemic of the 19(th) and 20(th) centuries, during which plague was spread around the world, and the second pandemic of the 14(th)-17(th) centuries, which included the infamous epidemic known as the Black Death. Previous studies have confirmed that Y. pestis caused these two more recent pandemics. However, a highly spirited debate still continues as to whether Y. pestis caused the so-called Justinianic Plague of the 6(th)-8(th) centuries AD. By analyzing ancient DNA in two independent ancient DNA laboratories, we confirmed unambiguously the presence of Y. pestis DNA in human skeletal remains from an Early Medieval cemetery. In addition, we narrowed the phylogenetic position of the responsible strain down to major branch 0 on the Y. pestis phylogeny, specifically between nodes N03 and N05. Our findings confirm that Y. pestis was responsible for the Justinianic Plague, which should end the controversy regarding the etiology of this pandemic. The first genotype of a Y. pestis strain that caused the Late Antique plague provides important information about the history of the plague bacillus and suggests that the first pandemic also originated in Asia, similar to the other two plague pandemics.Michaela HarbeckLisa SeifertStephanie HänschDavid M WagnerDawn BirdsellKaty L PariseIngrid WiechmannGisela GrupeAstrid ThomasPaul KeimLothar ZöllerBarbara BramantiJulia M RiehmHolger C ScholzPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 9, Iss 5, p e1003349 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Michaela Harbeck Lisa Seifert Stephanie Hänsch David M Wagner Dawn Birdsell Katy L Parise Ingrid Wiechmann Gisela Grupe Astrid Thomas Paul Keim Lothar Zöller Barbara Bramanti Julia M Riehm Holger C Scholz Yersinia pestis DNA from skeletal remains from the 6(th) century AD reveals insights into Justinianic Plague.
description	Yersinia pestis, the etiologic agent of the disease plague, has been implicated in three historical pandemics. These include the third pandemic of the 19(th) and 20(th) centuries, during which plague was spread around the world, and the second pandemic of the 14(th)-17(th) centuries, which included the infamous epidemic known as the Black Death. Previous studies have confirmed that Y. pestis caused these two more recent pandemics. However, a highly spirited debate still continues as to whether Y. pestis caused the so-called Justinianic Plague of the 6(th)-8(th) centuries AD. By analyzing ancient DNA in two independent ancient DNA laboratories, we confirmed unambiguously the presence of Y. pestis DNA in human skeletal remains from an Early Medieval cemetery. In addition, we narrowed the phylogenetic position of the responsible strain down to major branch 0 on the Y. pestis phylogeny, specifically between nodes N03 and N05. Our findings confirm that Y. pestis was responsible for the Justinianic Plague, which should end the controversy regarding the etiology of this pandemic. The first genotype of a Y. pestis strain that caused the Late Antique plague provides important information about the history of the plague bacillus and suggests that the first pandemic also originated in Asia, similar to the other two plague pandemics.
format	article
author	Michaela Harbeck Lisa Seifert Stephanie Hänsch David M Wagner Dawn Birdsell Katy L Parise Ingrid Wiechmann Gisela Grupe Astrid Thomas Paul Keim Lothar Zöller Barbara Bramanti Julia M Riehm Holger C Scholz
author_facet	Michaela Harbeck Lisa Seifert Stephanie Hänsch David M Wagner Dawn Birdsell Katy L Parise Ingrid Wiechmann Gisela Grupe Astrid Thomas Paul Keim Lothar Zöller Barbara Bramanti Julia M Riehm Holger C Scholz
author_sort	Michaela Harbeck
title	Yersinia pestis DNA from skeletal remains from the 6(th) century AD reveals insights into Justinianic Plague.
title_short	Yersinia pestis DNA from skeletal remains from the 6(th) century AD reveals insights into Justinianic Plague.
title_full	Yersinia pestis DNA from skeletal remains from the 6(th) century AD reveals insights into Justinianic Plague.
title_fullStr	Yersinia pestis DNA from skeletal remains from the 6(th) century AD reveals insights into Justinianic Plague.
title_full_unstemmed	Yersinia pestis DNA from skeletal remains from the 6(th) century AD reveals insights into Justinianic Plague.
title_sort	yersinia pestis dna from skeletal remains from the 6(th) century ad reveals insights into justinianic plague.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/91250c94b6804f5ebedbf3569f5f2bf5
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Yersinia pestis DNA from skeletal remains from the 6(th) century AD reveals insights into Justinianic Plague.

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