From Cell Death to Metabolism: Holin-Antiholin Homologues with New Functions

ABSTRACT Programmed cell death in bacteria is generally triggered by membrane proteins with functions analogous to those of bacteriophage holins: they disrupt the membrane potential, whereas antiholins antagonize this process. The holin-like class of proteins is present in all three domains of life,...

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Autores principales:	Marielle H. van den Esker, Ákos T. Kovács, Oscar P. Kuipers
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2017
Materias:	Bacillus subtilis Staphylococcus aureus antiholin evolution holin metabolism Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/9126d8426a734032b384f1559a440cdc
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spelling	oai:doaj.org-article:9126d8426a734032b384f1559a440cdc2021-11-15T15:51:56ZFrom Cell Death to Metabolism: Holin-Antiholin Homologues with New Functions10.1128/mBio.01963-172150-7511https://doaj.org/article/9126d8426a734032b384f1559a440cdc2017-12-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01963-17https://doaj.org/toc/2150-7511ABSTRACT Programmed cell death in bacteria is generally triggered by membrane proteins with functions analogous to those of bacteriophage holins: they disrupt the membrane potential, whereas antiholins antagonize this process. The holin-like class of proteins is present in all three domains of life, but their functions can be different, depending on the species. Using a series of biochemical and genetic approaches, in a recent article in mBio, Charbonnier et al. (mBio 8:e00976-17, 2017, https://doi.org/10.1128/mBio.00976-17 ) demonstrate that the antiholin homologue in Bacillus subtilis transports pyruvate and is regulated in an unconventional way by its substrate molecule. Here, we discuss the connection between cell death and metabolism in various bacteria carrying genes encoding these holin-antiholin analogues and place the recent study by Charbonnier et al. in an evolutionary context.Marielle H. van den EskerÁkos T. KovácsOscar P. KuipersAmerican Society for MicrobiologyarticleBacillus subtilisStaphylococcus aureusantiholinevolutionholinmetabolismMicrobiologyQR1-502ENmBio, Vol 8, Iss 6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Bacillus subtilis Staphylococcus aureus antiholin evolution holin metabolism Microbiology QR1-502
spellingShingle	Bacillus subtilis Staphylococcus aureus antiholin evolution holin metabolism Microbiology QR1-502 Marielle H. van den Esker Ákos T. Kovács Oscar P. Kuipers From Cell Death to Metabolism: Holin-Antiholin Homologues with New Functions
description	ABSTRACT Programmed cell death in bacteria is generally triggered by membrane proteins with functions analogous to those of bacteriophage holins: they disrupt the membrane potential, whereas antiholins antagonize this process. The holin-like class of proteins is present in all three domains of life, but their functions can be different, depending on the species. Using a series of biochemical and genetic approaches, in a recent article in mBio, Charbonnier et al. (mBio 8:e00976-17, 2017, https://doi.org/10.1128/mBio.00976-17 ) demonstrate that the antiholin homologue in Bacillus subtilis transports pyruvate and is regulated in an unconventional way by its substrate molecule. Here, we discuss the connection between cell death and metabolism in various bacteria carrying genes encoding these holin-antiholin analogues and place the recent study by Charbonnier et al. in an evolutionary context.
format	article
author	Marielle H. van den Esker Ákos T. Kovács Oscar P. Kuipers
author_facet	Marielle H. van den Esker Ákos T. Kovács Oscar P. Kuipers
author_sort	Marielle H. van den Esker
title	From Cell Death to Metabolism: Holin-Antiholin Homologues with New Functions
title_short	From Cell Death to Metabolism: Holin-Antiholin Homologues with New Functions
title_full	From Cell Death to Metabolism: Holin-Antiholin Homologues with New Functions
title_fullStr	From Cell Death to Metabolism: Holin-Antiholin Homologues with New Functions
title_full_unstemmed	From Cell Death to Metabolism: Holin-Antiholin Homologues with New Functions
title_sort	from cell death to metabolism: holin-antiholin homologues with new functions
publisher	American Society for Microbiology
publishDate	2017
url	https://doaj.org/article/9126d8426a734032b384f1559a440cdc
work_keys_str_mv	AT mariellehvandenesker fromcelldeathtometabolismholinantiholinhomologueswithnewfunctions AT akostkovacs fromcelldeathtometabolismholinantiholinhomologueswithnewfunctions AT oscarpkuipers fromcelldeathtometabolismholinantiholinhomologueswithnewfunctions
_version_	1718427289595674624

From Cell Death to Metabolism: Holin-Antiholin Homologues with New Functions

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