Metabolic and inflammatory biomarkers in children with atopic dermatitis (AD): a case-control study

Abstract Background Atopic dermatitis is characterized by impaired skin barrier and altered cutaneous innate immunity. The estimated prevalence among Egyptian children was 10–12%. Several studies suggest that it may be associated with systemic comorbidities other than the spectrum of atopy, such as...

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Autores principales:	Amal Ahmed Mohamed, Eman Mohamed Salah, Nermeen Ibrahim Bedair, Dina M. Bassiouny, Aliaa E. M. Daifalla, Ola G. Behairy, Naglaa Fawazy, Mohamed F. Al Soda, Youssef M. K. Farag
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Atopic dermatitis Diabetes Dyslipidemia C reactive protein IgE Glutamyl gamma transferase Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/912a65bed4d6401bbe108793d062d6fc
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spelling	oai:doaj.org-article:912a65bed4d6401bbe108793d062d6fc2021-11-08T11:15:11ZMetabolic and inflammatory biomarkers in children with atopic dermatitis (AD): a case-control study10.1186/s43054-021-00083-x2090-9942https://doaj.org/article/912a65bed4d6401bbe108793d062d6fc2021-11-01T00:00:00Zhttps://doi.org/10.1186/s43054-021-00083-xhttps://doaj.org/toc/2090-9942Abstract Background Atopic dermatitis is characterized by impaired skin barrier and altered cutaneous innate immunity. The estimated prevalence among Egyptian children was 10–12%. Several studies suggest that it may be associated with systemic comorbidities other than the spectrum of atopy, such as metabolic syndrome and other inflammatory conditions. The aim of this study is to compare the profile of systemic conditions of diabetes, dyslipidemia, and multiple inflammatory markers in children with and without diagnosed atopic dermatitis. Methods One hundred atopic dermatitis patients and 101 normal controls were collected from outpatient clinic based on their clinical condition, both had measurement of body mass index, blood sugar, serum insulin, lipid profile, C reactive protein, and gamma-glutamyl transferase. Results Children diagnosed with atopic dermatitis had significantly higher levels of body mass index (34.7 ± 5.7 vs 26.1 ± 4.9), fasting glucose (143.2 ± 30.3 vs 100.8 ± 16.0), serum insulin (11.3 ± 4.4 vs. 4.6 ± 3.0), serum triglycerides (194.1 ± 38.1 vs 156.2 ± 31.6), total cholesterol (198.4 ± 27.7 vs 163.7 ± 27.7), alkaline phosphatase (229.4 ± 89.8 vs. 189.4 ± 46.8), and gamma-glutamyl transferase (54.7 ± 19.9 vs 34.3 ± 9.5), C-reactive protein level was approximately four times higher (19.9 ± 13.2 vs 5.1 ± 3.4) and the immunoglobulin E level was approximately 10 times higher (2050.3 ± 843.8 vs 252.7 ± 103.1) than in controls Conclusion We found a positive relationship of atopic dermatitis with both diabetes and hyperlipidemia among children, and positive dose-response relationship of several non-traditional biomarkers of C-reactive protein, gamma-glutamyl transferase, and alkaline phosphatase with the presence and severity of atopic dermatitis.Amal Ahmed MohamedEman Mohamed SalahNermeen Ibrahim BedairDina M. BassiounyAliaa E. M. DaifallaOla G. BehairyNaglaa FawazyMohamed F. Al SodaYoussef M. K. FaragSpringerOpenarticleAtopic dermatitisDiabetesDyslipidemiaC reactive proteinIgEGlutamyl gamma transferasePediatricsRJ1-570ENEgyptian Pediatric Association Gazette, Vol 69, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Atopic dermatitis Diabetes Dyslipidemia C reactive protein IgE Glutamyl gamma transferase Pediatrics RJ1-570
spellingShingle	Atopic dermatitis Diabetes Dyslipidemia C reactive protein IgE Glutamyl gamma transferase Pediatrics RJ1-570 Amal Ahmed Mohamed Eman Mohamed Salah Nermeen Ibrahim Bedair Dina M. Bassiouny Aliaa E. M. Daifalla Ola G. Behairy Naglaa Fawazy Mohamed F. Al Soda Youssef M. K. Farag Metabolic and inflammatory biomarkers in children with atopic dermatitis (AD): a case-control study
description	Abstract Background Atopic dermatitis is characterized by impaired skin barrier and altered cutaneous innate immunity. The estimated prevalence among Egyptian children was 10–12%. Several studies suggest that it may be associated with systemic comorbidities other than the spectrum of atopy, such as metabolic syndrome and other inflammatory conditions. The aim of this study is to compare the profile of systemic conditions of diabetes, dyslipidemia, and multiple inflammatory markers in children with and without diagnosed atopic dermatitis. Methods One hundred atopic dermatitis patients and 101 normal controls were collected from outpatient clinic based on their clinical condition, both had measurement of body mass index, blood sugar, serum insulin, lipid profile, C reactive protein, and gamma-glutamyl transferase. Results Children diagnosed with atopic dermatitis had significantly higher levels of body mass index (34.7 ± 5.7 vs 26.1 ± 4.9), fasting glucose (143.2 ± 30.3 vs 100.8 ± 16.0), serum insulin (11.3 ± 4.4 vs. 4.6 ± 3.0), serum triglycerides (194.1 ± 38.1 vs 156.2 ± 31.6), total cholesterol (198.4 ± 27.7 vs 163.7 ± 27.7), alkaline phosphatase (229.4 ± 89.8 vs. 189.4 ± 46.8), and gamma-glutamyl transferase (54.7 ± 19.9 vs 34.3 ± 9.5), C-reactive protein level was approximately four times higher (19.9 ± 13.2 vs 5.1 ± 3.4) and the immunoglobulin E level was approximately 10 times higher (2050.3 ± 843.8 vs 252.7 ± 103.1) than in controls Conclusion We found a positive relationship of atopic dermatitis with both diabetes and hyperlipidemia among children, and positive dose-response relationship of several non-traditional biomarkers of C-reactive protein, gamma-glutamyl transferase, and alkaline phosphatase with the presence and severity of atopic dermatitis.
format	article
author	Amal Ahmed Mohamed Eman Mohamed Salah Nermeen Ibrahim Bedair Dina M. Bassiouny Aliaa E. M. Daifalla Ola G. Behairy Naglaa Fawazy Mohamed F. Al Soda Youssef M. K. Farag
author_facet	Amal Ahmed Mohamed Eman Mohamed Salah Nermeen Ibrahim Bedair Dina M. Bassiouny Aliaa E. M. Daifalla Ola G. Behairy Naglaa Fawazy Mohamed F. Al Soda Youssef M. K. Farag
author_sort	Amal Ahmed Mohamed
title	Metabolic and inflammatory biomarkers in children with atopic dermatitis (AD): a case-control study
title_short	Metabolic and inflammatory biomarkers in children with atopic dermatitis (AD): a case-control study
title_full	Metabolic and inflammatory biomarkers in children with atopic dermatitis (AD): a case-control study
title_fullStr	Metabolic and inflammatory biomarkers in children with atopic dermatitis (AD): a case-control study
title_full_unstemmed	Metabolic and inflammatory biomarkers in children with atopic dermatitis (AD): a case-control study
title_sort	metabolic and inflammatory biomarkers in children with atopic dermatitis (ad): a case-control study
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/912a65bed4d6401bbe108793d062d6fc
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Metabolic and inflammatory biomarkers in children with atopic dermatitis (AD): a case-control study

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