Outer-membrane-acting peptides and lipid II-targeting antibiotics cooperatively kill Gram-negative pathogens

Li, Cebrian et al. show that a combination of peptide D-11 and vancomycin exhibits a potent antimicrobial activity against a panel of Gram-negative pathogens without apparent toxicity. They find that this combination is also effective in clearing Pseudomonas aeruginosa in mice, providing a potential...

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Autores principales:	Qian Li, Rubén Cebrián, Manuel Montalbán-López, Huan Ren, Weihui Wu, Oscar P. Kuipers
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/912c6d829b084385a8edefa3d512316c
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spelling	oai:doaj.org-article:912c6d829b084385a8edefa3d512316c2021-12-02T11:56:22ZOuter-membrane-acting peptides and lipid II-targeting antibiotics cooperatively kill Gram-negative pathogens10.1038/s42003-020-01511-12399-3642https://doaj.org/article/912c6d829b084385a8edefa3d512316c2021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01511-1https://doaj.org/toc/2399-3642Li, Cebrian et al. show that a combination of peptide D-11 and vancomycin exhibits a potent antimicrobial activity against a panel of Gram-negative pathogens without apparent toxicity. They find that this combination is also effective in clearing Pseudomonas aeruginosa in mice, providing a potential antimicrobial therapy for humans.Qian LiRubén CebriánManuel Montalbán-LópezHuan RenWeihui WuOscar P. KuipersNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Qian Li Rubén Cebrián Manuel Montalbán-López Huan Ren Weihui Wu Oscar P. Kuipers Outer-membrane-acting peptides and lipid II-targeting antibiotics cooperatively kill Gram-negative pathogens
description	Li, Cebrian et al. show that a combination of peptide D-11 and vancomycin exhibits a potent antimicrobial activity against a panel of Gram-negative pathogens without apparent toxicity. They find that this combination is also effective in clearing Pseudomonas aeruginosa in mice, providing a potential antimicrobial therapy for humans.
format	article
author	Qian Li Rubén Cebrián Manuel Montalbán-López Huan Ren Weihui Wu Oscar P. Kuipers
author_facet	Qian Li Rubén Cebrián Manuel Montalbán-López Huan Ren Weihui Wu Oscar P. Kuipers
author_sort	Qian Li
title	Outer-membrane-acting peptides and lipid II-targeting antibiotics cooperatively kill Gram-negative pathogens
title_short	Outer-membrane-acting peptides and lipid II-targeting antibiotics cooperatively kill Gram-negative pathogens
title_full	Outer-membrane-acting peptides and lipid II-targeting antibiotics cooperatively kill Gram-negative pathogens
title_fullStr	Outer-membrane-acting peptides and lipid II-targeting antibiotics cooperatively kill Gram-negative pathogens
title_full_unstemmed	Outer-membrane-acting peptides and lipid II-targeting antibiotics cooperatively kill Gram-negative pathogens
title_sort	outer-membrane-acting peptides and lipid ii-targeting antibiotics cooperatively kill gram-negative pathogens
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/912c6d829b084385a8edefa3d512316c
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Outer-membrane-acting peptides and lipid II-targeting antibiotics cooperatively kill Gram-negative pathogens

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