COGNITIVE IMPAIRMENT IN HYPERTENSIVES

Background: Hypertension and dementia increase parallel to age. Objective: The purpose of this study was to study the effect of hypertension on cognition before age-related cognitive impairment begins to set in. Methods: In this prospective, cross-sectional study conducted at a tertiary-care c...

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Autores principales:	Natasha Tipnis, Girish Rajadhyaksha, Meghav Shah
Formato:	article
Lenguaje:	EN ID
Publicado:	University of Brawijaya 2021
Materias:	age cognitive impairment dementia hindi mini-mental state exam hypertension Medicine R Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/91327a4c913a4b94a07711da917f9c71
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spelling	oai:doaj.org-article:91327a4c913a4b94a07711da917f9c712021-11-24T05:15:00ZCOGNITIVE IMPAIRMENT IN HYPERTENSIVES10.21776/ub.mnj.2021.007.02.32407-67242442-5001https://doaj.org/article/91327a4c913a4b94a07711da917f9c712021-07-01T00:00:00Zhttps://mnj.ub.ac.id/index.php/mnj/article/view/471https://doaj.org/toc/2407-6724https://doaj.org/toc/2442-5001Background: Hypertension and dementia increase parallel to age. Objective: The purpose of this study was to study the effect of hypertension on cognition before age-related cognitive impairment begins to set in. Methods: In this prospective, cross-sectional study conducted at a tertiary-care centre between May 2014 and December 2015, 300 (150 hypertensives and 150 normotensives) participants were compared. Patients were divided into groups according to age, gender, education, and duration of hypertension. The Hindi Mini-Mental State Examination (HMMSE) was used to detect cognitive impairment. Results: Overall, occurrence of cognitive impairment was 53 (35.3%) in hypertensives and 37 (24.7%) in normotensives. Below 60 years male and female hypertensives and normotensives had comparable mean HMMSE scores, although not statistically significant. Sixty years and above male and female normotensives achieved slightly higher HMMSE scores than male and female hypertensives, however this finding was statistically significant (p=0.002) for males ≥60 years. Among the cognitive domains, orientation to time (p=0.009), registration (p=0.018), recall (p=0.031), and 3 step command (p=0.014) were statistically different between hypertensives and normotensives. Periventricular white matter ischemia was discovered in 8 (5.3%) and 2 (1.3%) hypertensives and normotensives, respectively. Conclusion: Although hypertension was not statistically associated with cognitive decline in hypertensives <60 years, hypertensives >60 years showed statistical significance with cognitive decline. Furthermore, specific cognitive domains such as orientation to time, registration, recall, and 3 step command displayed statistical significance for cognitive decline. Future prospective, large-scale studies are warranted to investigate these and other possible associations.Natasha TipnisGirish RajadhyakshaMeghav ShahUniversity of Brawijayaarticleagecognitive impairmentdementiahindi mini-mental state examhypertensionMedicineRNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENIDMalang Neurology Journal, Vol 7, Iss 2, Pp 98-103 (2021)
institution	DOAJ
collection	DOAJ
language	EN ID
topic	age cognitive impairment dementia hindi mini-mental state exam hypertension Medicine R Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	age cognitive impairment dementia hindi mini-mental state exam hypertension Medicine R Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Natasha Tipnis Girish Rajadhyaksha Meghav Shah COGNITIVE IMPAIRMENT IN HYPERTENSIVES
description	Background: Hypertension and dementia increase parallel to age. Objective: The purpose of this study was to study the effect of hypertension on cognition before age-related cognitive impairment begins to set in. Methods: In this prospective, cross-sectional study conducted at a tertiary-care centre between May 2014 and December 2015, 300 (150 hypertensives and 150 normotensives) participants were compared. Patients were divided into groups according to age, gender, education, and duration of hypertension. The Hindi Mini-Mental State Examination (HMMSE) was used to detect cognitive impairment. Results: Overall, occurrence of cognitive impairment was 53 (35.3%) in hypertensives and 37 (24.7%) in normotensives. Below 60 years male and female hypertensives and normotensives had comparable mean HMMSE scores, although not statistically significant. Sixty years and above male and female normotensives achieved slightly higher HMMSE scores than male and female hypertensives, however this finding was statistically significant (p=0.002) for males ≥60 years. Among the cognitive domains, orientation to time (p=0.009), registration (p=0.018), recall (p=0.031), and 3 step command (p=0.014) were statistically different between hypertensives and normotensives. Periventricular white matter ischemia was discovered in 8 (5.3%) and 2 (1.3%) hypertensives and normotensives, respectively. Conclusion: Although hypertension was not statistically associated with cognitive decline in hypertensives <60 years, hypertensives >60 years showed statistical significance with cognitive decline. Furthermore, specific cognitive domains such as orientation to time, registration, recall, and 3 step command displayed statistical significance for cognitive decline. Future prospective, large-scale studies are warranted to investigate these and other possible associations.
format	article
author	Natasha Tipnis Girish Rajadhyaksha Meghav Shah
author_facet	Natasha Tipnis Girish Rajadhyaksha Meghav Shah
author_sort	Natasha Tipnis
title	COGNITIVE IMPAIRMENT IN HYPERTENSIVES
title_short	COGNITIVE IMPAIRMENT IN HYPERTENSIVES
title_full	COGNITIVE IMPAIRMENT IN HYPERTENSIVES
title_fullStr	COGNITIVE IMPAIRMENT IN HYPERTENSIVES
title_full_unstemmed	COGNITIVE IMPAIRMENT IN HYPERTENSIVES
title_sort	cognitive impairment in hypertensives
publisher	University of Brawijaya
publishDate	2021
url	https://doaj.org/article/91327a4c913a4b94a07711da917f9c71
work_keys_str_mv	AT natashatipnis cognitiveimpairmentinhypertensives AT girishrajadhyaksha cognitiveimpairmentinhypertensives AT meghavshah cognitiveimpairmentinhypertensives
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COGNITIVE IMPAIRMENT IN HYPERTENSIVES

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