The genetic architecture of age-related hearing impairment revealed by genome-wide association analysis

The genetic architecture of age-related hearing impairment revealed by genome-wide association analysis

Erna Ivarsdottir et al. report a genome-wide association meta-analysis for age-related hearing loss in the Icelandic and UK populations. They identify 21 novel variants, 13 of which are rare, and reveal a genetic correlation between age-related hearing loss and tinnitus.

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Autores principales: Erna V. Ivarsdottir, Hilma Holm, Stefania Benonisdottir, Thorhildur Olafsdottir, Gardar Sveinbjornsson, Gudmar Thorleifsson, Hannes P. Eggertsson, Gisli H. Halldorsson, Kristjan E. Hjorleifsson, Pall Melsted, Arnaldur Gylfason, Gudny A. Arnadottir, Asmundur Oddsson, Brynjar O. Jensson, Aslaug Jonasdottir, Adalbjorg Jonasdottir, Thorhildur Juliusdottir, Lilja Stefansdottir, Vinicius Tragante, Bjarni V. Halldorsson, Hannes Petersen, Gudmundur Thorgeirsson, Unnur Thorsteinsdottir, Patrick Sulem, Ingibjorg Hinriksdottir, Ingileif Jonsdottir, Daniel F. Gudbjartsson, Kari Stefansson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/91335cb2943443128986683d51832e1d
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spelling oai:doaj.org-article:91335cb2943443128986683d51832e1d2021-12-02T17:52:40ZThe genetic architecture of age-related hearing impairment revealed by genome-wide association analysis10.1038/s42003-021-02224-92399-3642https://doaj.org/article/91335cb2943443128986683d51832e1d2021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02224-9https://doaj.org/toc/2399-3642Erna Ivarsdottir et al. report a genome-wide association meta-analysis for age-related hearing loss in the Icelandic and UK populations. They identify 21 novel variants, 13 of which are rare, and reveal a genetic correlation between age-related hearing loss and tinnitus.Erna V. IvarsdottirHilma HolmStefania BenonisdottirThorhildur OlafsdottirGardar SveinbjornssonGudmar ThorleifssonHannes P. EggertssonGisli H. HalldorssonKristjan E. HjorleifssonPall MelstedArnaldur GylfasonGudny A. ArnadottirAsmundur OddssonBrynjar O. JenssonAslaug JonasdottirAdalbjorg JonasdottirThorhildur JuliusdottirLilja StefansdottirVinicius TraganteBjarni V. HalldorssonHannes PetersenGudmundur ThorgeirssonUnnur ThorsteinsdottirPatrick SulemIngibjorg HinriksdottirIngileif JonsdottirDaniel F. GudbjartssonKari StefanssonNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Erna V. Ivarsdottir
Hilma Holm
Stefania Benonisdottir
Thorhildur Olafsdottir
Gardar Sveinbjornsson
Gudmar Thorleifsson
Hannes P. Eggertsson
Gisli H. Halldorsson
Kristjan E. Hjorleifsson
Pall Melsted
Arnaldur Gylfason
Gudny A. Arnadottir
Asmundur Oddsson
Brynjar O. Jensson
Aslaug Jonasdottir
Adalbjorg Jonasdottir
Thorhildur Juliusdottir
Lilja Stefansdottir
Vinicius Tragante
Bjarni V. Halldorsson
Hannes Petersen
Gudmundur Thorgeirsson
Unnur Thorsteinsdottir
Patrick Sulem
Ingibjorg Hinriksdottir
Ingileif Jonsdottir
Daniel F. Gudbjartsson
Kari Stefansson
The genetic architecture of age-related hearing impairment revealed by genome-wide association analysis
description Erna Ivarsdottir et al. report a genome-wide association meta-analysis for age-related hearing loss in the Icelandic and UK populations. They identify 21 novel variants, 13 of which are rare, and reveal a genetic correlation between age-related hearing loss and tinnitus.
format article
author Erna V. Ivarsdottir
Hilma Holm
Stefania Benonisdottir
Thorhildur Olafsdottir
Gardar Sveinbjornsson
Gudmar Thorleifsson
Hannes P. Eggertsson
Gisli H. Halldorsson
Kristjan E. Hjorleifsson
Pall Melsted
Arnaldur Gylfason
Gudny A. Arnadottir
Asmundur Oddsson
Brynjar O. Jensson
Aslaug Jonasdottir
Adalbjorg Jonasdottir
Thorhildur Juliusdottir
Lilja Stefansdottir
Vinicius Tragante
Bjarni V. Halldorsson
Hannes Petersen
Gudmundur Thorgeirsson
Unnur Thorsteinsdottir
Patrick Sulem
Ingibjorg Hinriksdottir
Ingileif Jonsdottir
Daniel F. Gudbjartsson
Kari Stefansson
author_facet Erna V. Ivarsdottir
Hilma Holm
Stefania Benonisdottir
Thorhildur Olafsdottir
Gardar Sveinbjornsson
Gudmar Thorleifsson
Hannes P. Eggertsson
Gisli H. Halldorsson
Kristjan E. Hjorleifsson
Pall Melsted
Arnaldur Gylfason
Gudny A. Arnadottir
Asmundur Oddsson
Brynjar O. Jensson
Aslaug Jonasdottir
Adalbjorg Jonasdottir
Thorhildur Juliusdottir
Lilja Stefansdottir
Vinicius Tragante
Bjarni V. Halldorsson
Hannes Petersen
Gudmundur Thorgeirsson
Unnur Thorsteinsdottir
Patrick Sulem
Ingibjorg Hinriksdottir
Ingileif Jonsdottir
Daniel F. Gudbjartsson
Kari Stefansson
author_sort Erna V. Ivarsdottir
title The genetic architecture of age-related hearing impairment revealed by genome-wide association analysis
title_short The genetic architecture of age-related hearing impairment revealed by genome-wide association analysis
title_full The genetic architecture of age-related hearing impairment revealed by genome-wide association analysis
title_fullStr The genetic architecture of age-related hearing impairment revealed by genome-wide association analysis
title_full_unstemmed The genetic architecture of age-related hearing impairment revealed by genome-wide association analysis
title_sort genetic architecture of age-related hearing impairment revealed by genome-wide association analysis
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/91335cb2943443128986683d51832e1d
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