MRPS31 loss is a key driver of mitochondrial deregulation and hepatocellular carcinoma aggressiveness

Abstract Deregulated mitochondrial energetics is a metabolic hallmark of cancer cells. However, the causative mechanism of the bioenergetic deregulation is not clear. In this study, we show that somatic copy number alteration (SCNA) of mitoribosomal protein (MRP) genes is a key mechanism of bioenerg...

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Autores principales: Seongki Min, Young-Kyoung Lee, Jiwon Hong, Tae Jun Park, Hyun Goo Woo, So Mee Kwon, Gyesoon Yoon
Formato: article
Lenguaje:EN
Publicado: Nature Publishing Group 2021
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Acceso en línea:https://doaj.org/article/9137da938a5642118402603ae6bbad42
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