Robust inference of kinase activity using functional networks

Kinases drive fundamental changes in cell state, but predicting kinase activity based on substrate-level changes can be challenging. Here the authors introduce a computational framework that utilizes similarities between substrates to robustly infer kinase activity.

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Autores principales:	Serhan Yılmaz, Marzieh Ayati, Daniela Schlatzer, A. Ercüment Çiçek, Mark R. Chance, Mehmet Koyutürk
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/91396e4de4ab46f3a89cbb70ee623194
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spelling	oai:doaj.org-article:91396e4de4ab46f3a89cbb70ee6231942021-12-02T14:03:51ZRobust inference of kinase activity using functional networks10.1038/s41467-021-21211-62041-1723https://doaj.org/article/91396e4de4ab46f3a89cbb70ee6231942021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21211-6https://doaj.org/toc/2041-1723Kinases drive fundamental changes in cell state, but predicting kinase activity based on substrate-level changes can be challenging. Here the authors introduce a computational framework that utilizes similarities between substrates to robustly infer kinase activity.Serhan YılmazMarzieh AyatiDaniela SchlatzerA. Ercüment ÇiçekMark R. ChanceMehmet KoyutürkNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Serhan Yılmaz Marzieh Ayati Daniela Schlatzer A. Ercüment Çiçek Mark R. Chance Mehmet Koyutürk Robust inference of kinase activity using functional networks
description	Kinases drive fundamental changes in cell state, but predicting kinase activity based on substrate-level changes can be challenging. Here the authors introduce a computational framework that utilizes similarities between substrates to robustly infer kinase activity.
format	article
author	Serhan Yılmaz Marzieh Ayati Daniela Schlatzer A. Ercüment Çiçek Mark R. Chance Mehmet Koyutürk
author_facet	Serhan Yılmaz Marzieh Ayati Daniela Schlatzer A. Ercüment Çiçek Mark R. Chance Mehmet Koyutürk
author_sort	Serhan Yılmaz
title	Robust inference of kinase activity using functional networks
title_short	Robust inference of kinase activity using functional networks
title_full	Robust inference of kinase activity using functional networks
title_fullStr	Robust inference of kinase activity using functional networks
title_full_unstemmed	Robust inference of kinase activity using functional networks
title_sort	robust inference of kinase activity using functional networks
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/91396e4de4ab46f3a89cbb70ee623194
work_keys_str_mv	AT serhanyılmaz robustinferenceofkinaseactivityusingfunctionalnetworks AT marziehayati robustinferenceofkinaseactivityusingfunctionalnetworks AT danielaschlatzer robustinferenceofkinaseactivityusingfunctionalnetworks AT aercumentcicek robustinferenceofkinaseactivityusingfunctionalnetworks AT markrchance robustinferenceofkinaseactivityusingfunctionalnetworks AT mehmetkoyuturk robustinferenceofkinaseactivityusingfunctionalnetworks
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Robust inference of kinase activity using functional networks

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