GIGYF1 loss of function is associated with clonal mosaicism and adverse metabolic health

Mosaic loss of chromosome Y (LOY) is a common form of clonal mosaicism in leukocytes. Here, the authors extend genetic association analyses to rare variation using exome-sequence data from 82,277 males, finding that loss-of-function alleles in GIGYF1 are associated with six-fold higher susceptibilit...

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Autores principales:	Yajie Zhao, Stasa Stankovic, Mine Koprulu, Eleanor Wheeler, Felix R. Day, Hana Lango Allen, Nicola D. Kerrison, Maik Pietzner, Po-Ru Loh, Nicholas J. Wareham, Claudia Langenberg, Ken K. Ong, John R. B. Perry
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/913fdc222dc74e48854e6709b1ef3e16
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spelling	oai:doaj.org-article:913fdc222dc74e48854e6709b1ef3e162021-12-02T18:34:15ZGIGYF1 loss of function is associated with clonal mosaicism and adverse metabolic health10.1038/s41467-021-24504-y2041-1723https://doaj.org/article/913fdc222dc74e48854e6709b1ef3e162021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24504-yhttps://doaj.org/toc/2041-1723Mosaic loss of chromosome Y (LOY) is a common form of clonal mosaicism in leukocytes. Here, the authors extend genetic association analyses to rare variation using exome-sequence data from 82,277 males, finding that loss-of-function alleles in GIGYF1 are associated with six-fold higher susceptibility to both LOY and Type 2 Diabetes.Yajie ZhaoStasa StankovicMine KopruluEleanor WheelerFelix R. DayHana Lango AllenNicola D. KerrisonMaik PietznerPo-Ru LohNicholas J. WarehamClaudia LangenbergKen K. OngJohn R. B. PerryNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yajie Zhao Stasa Stankovic Mine Koprulu Eleanor Wheeler Felix R. Day Hana Lango Allen Nicola D. Kerrison Maik Pietzner Po-Ru Loh Nicholas J. Wareham Claudia Langenberg Ken K. Ong John R. B. Perry GIGYF1 loss of function is associated with clonal mosaicism and adverse metabolic health
description	Mosaic loss of chromosome Y (LOY) is a common form of clonal mosaicism in leukocytes. Here, the authors extend genetic association analyses to rare variation using exome-sequence data from 82,277 males, finding that loss-of-function alleles in GIGYF1 are associated with six-fold higher susceptibility to both LOY and Type 2 Diabetes.
format	article
author	Yajie Zhao Stasa Stankovic Mine Koprulu Eleanor Wheeler Felix R. Day Hana Lango Allen Nicola D. Kerrison Maik Pietzner Po-Ru Loh Nicholas J. Wareham Claudia Langenberg Ken K. Ong John R. B. Perry
author_facet	Yajie Zhao Stasa Stankovic Mine Koprulu Eleanor Wheeler Felix R. Day Hana Lango Allen Nicola D. Kerrison Maik Pietzner Po-Ru Loh Nicholas J. Wareham Claudia Langenberg Ken K. Ong John R. B. Perry
author_sort	Yajie Zhao
title	GIGYF1 loss of function is associated with clonal mosaicism and adverse metabolic health
title_short	GIGYF1 loss of function is associated with clonal mosaicism and adverse metabolic health
title_full	GIGYF1 loss of function is associated with clonal mosaicism and adverse metabolic health
title_fullStr	GIGYF1 loss of function is associated with clonal mosaicism and adverse metabolic health
title_full_unstemmed	GIGYF1 loss of function is associated with clonal mosaicism and adverse metabolic health
title_sort	gigyf1 loss of function is associated with clonal mosaicism and adverse metabolic health
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/913fdc222dc74e48854e6709b1ef3e16
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GIGYF1 loss of function is associated with clonal mosaicism and adverse metabolic health

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