Design of live attenuated bacterial vaccines based on D-glutamate auxotrophy

D-glutamate is an essential component of the bacterial cell wall. Here, the authors use mouse models of infection withAcinetobacter baumannii, Pseudomonas aeruginosa and Staphylococcus aureusto show that bacterial mutants unable to synthesize D-glutamate can potentially be used as live attenuated va...

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Autores principales: Maria P. Cabral, Patricia García, Alejandro Beceiro, Carlos Rumbo, Astrid Pérez, Miriam Moscoso, Germán Bou
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/91413f1e730e4b6cb7f8e756a2aac42e
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Sumario:D-glutamate is an essential component of the bacterial cell wall. Here, the authors use mouse models of infection withAcinetobacter baumannii, Pseudomonas aeruginosa and Staphylococcus aureusto show that bacterial mutants unable to synthesize D-glutamate can potentially be used as live attenuated vaccines.