Design of live attenuated bacterial vaccines based on D-glutamate auxotrophy

D-glutamate is an essential component of the bacterial cell wall. Here, the authors use mouse models of infection withAcinetobacter baumannii, Pseudomonas aeruginosa and Staphylococcus aureusto show that bacterial mutants unable to synthesize D-glutamate can potentially be used as live attenuated va...

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Autores principales:	Maria P. Cabral, Patricia García, Alejandro Beceiro, Carlos Rumbo, Astrid Pérez, Miriam Moscoso, Germán Bou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/91413f1e730e4b6cb7f8e756a2aac42e
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spelling	oai:doaj.org-article:91413f1e730e4b6cb7f8e756a2aac42e2021-12-02T14:41:21ZDesign of live attenuated bacterial vaccines based on D-glutamate auxotrophy10.1038/ncomms154802041-1723https://doaj.org/article/91413f1e730e4b6cb7f8e756a2aac42e2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15480https://doaj.org/toc/2041-1723D-glutamate is an essential component of the bacterial cell wall. Here, the authors use mouse models of infection withAcinetobacter baumannii, Pseudomonas aeruginosa and Staphylococcus aureusto show that bacterial mutants unable to synthesize D-glutamate can potentially be used as live attenuated vaccines.Maria P. CabralPatricia GarcíaAlejandro BeceiroCarlos RumboAstrid PérezMiriam MoscosoGermán BouNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maria P. Cabral Patricia García Alejandro Beceiro Carlos Rumbo Astrid Pérez Miriam Moscoso Germán Bou Design of live attenuated bacterial vaccines based on D-glutamate auxotrophy
description	D-glutamate is an essential component of the bacterial cell wall. Here, the authors use mouse models of infection withAcinetobacter baumannii, Pseudomonas aeruginosa and Staphylococcus aureusto show that bacterial mutants unable to synthesize D-glutamate can potentially be used as live attenuated vaccines.
format	article
author	Maria P. Cabral Patricia García Alejandro Beceiro Carlos Rumbo Astrid Pérez Miriam Moscoso Germán Bou
author_facet	Maria P. Cabral Patricia García Alejandro Beceiro Carlos Rumbo Astrid Pérez Miriam Moscoso Germán Bou
author_sort	Maria P. Cabral
title	Design of live attenuated bacterial vaccines based on D-glutamate auxotrophy
title_short	Design of live attenuated bacterial vaccines based on D-glutamate auxotrophy
title_full	Design of live attenuated bacterial vaccines based on D-glutamate auxotrophy
title_fullStr	Design of live attenuated bacterial vaccines based on D-glutamate auxotrophy
title_full_unstemmed	Design of live attenuated bacterial vaccines based on D-glutamate auxotrophy
title_sort	design of live attenuated bacterial vaccines based on d-glutamate auxotrophy
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/91413f1e730e4b6cb7f8e756a2aac42e
work_keys_str_mv	AT mariapcabral designofliveattenuatedbacterialvaccinesbasedondglutamateauxotrophy AT patriciagarcia designofliveattenuatedbacterialvaccinesbasedondglutamateauxotrophy AT alejandrobeceiro designofliveattenuatedbacterialvaccinesbasedondglutamateauxotrophy AT carlosrumbo designofliveattenuatedbacterialvaccinesbasedondglutamateauxotrophy AT astridperez designofliveattenuatedbacterialvaccinesbasedondglutamateauxotrophy AT miriammoscoso designofliveattenuatedbacterialvaccinesbasedondglutamateauxotrophy AT germanbou designofliveattenuatedbacterialvaccinesbasedondglutamateauxotrophy
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Design of live attenuated bacterial vaccines based on D-glutamate auxotrophy

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