Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity

Mutations in presenilin, which cleaves amyloid precursor protein, cause familial Alzheimer’s Disease. Here, the authors show that loss of presenilin leads to loss of synaptotagmin 7, leading to impaired presynaptic release.

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Autores principales:	Gaël Barthet, Tomàs Jordà-Siquier, Julie Rumi-Masante, Fanny Bernadou, Ulrike Müller, Christophe Mulle
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9141dd69adf04d1c8a0ace613a53f522
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spelling	oai:doaj.org-article:9141dd69adf04d1c8a0ace613a53f5222021-12-02T14:40:44ZPresenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity10.1038/s41467-018-06813-x2041-1723https://doaj.org/article/9141dd69adf04d1c8a0ace613a53f5222018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06813-xhttps://doaj.org/toc/2041-1723Mutations in presenilin, which cleaves amyloid precursor protein, cause familial Alzheimer’s Disease. Here, the authors show that loss of presenilin leads to loss of synaptotagmin 7, leading to impaired presynaptic release.Gaël BarthetTomàs Jordà-SiquierJulie Rumi-MasanteFanny BernadouUlrike MüllerChristophe MulleNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gaël Barthet Tomàs Jordà-Siquier Julie Rumi-Masante Fanny Bernadou Ulrike Müller Christophe Mulle Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity
description	Mutations in presenilin, which cleaves amyloid precursor protein, cause familial Alzheimer’s Disease. Here, the authors show that loss of presenilin leads to loss of synaptotagmin 7, leading to impaired presynaptic release.
format	article
author	Gaël Barthet Tomàs Jordà-Siquier Julie Rumi-Masante Fanny Bernadou Ulrike Müller Christophe Mulle
author_facet	Gaël Barthet Tomàs Jordà-Siquier Julie Rumi-Masante Fanny Bernadou Ulrike Müller Christophe Mulle
author_sort	Gaël Barthet
title	Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity
title_short	Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity
title_full	Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity
title_fullStr	Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity
title_full_unstemmed	Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity
title_sort	presenilin-mediated cleavage of app regulates synaptotagmin-7 and presynaptic plasticity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9141dd69adf04d1c8a0ace613a53f522
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Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity

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