Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity
Mutations in presenilin, which cleaves amyloid precursor protein, cause familial Alzheimer’s Disease. Here, the authors show that loss of presenilin leads to loss of synaptotagmin 7, leading to impaired presynaptic release.
Guardado en:
Autores principales: | Gaël Barthet, Tomàs Jordà-Siquier, Julie Rumi-Masante, Fanny Bernadou, Ulrike Müller, Christophe Mulle |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2018
|
Materias: | |
Acceso en línea: | https://doaj.org/article/9141dd69adf04d1c8a0ace613a53f522 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Presenilin1 inhibits glioblastoma cell invasiveness via promoting Sortilin cleavage
por: Wei Yang, et al.
Publicado: (2021) -
CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage
por: Jichao Sun, et al.
Publicado: (2019) -
Synaptotagmin 7 switches short-term synaptic plasticity from depression to facilitation by suppressing synaptic transmission
por: Takaaki Fujii, et al.
Publicado: (2021) -
Presynaptic endoplasmic reticulum regulates short-term plasticity in hippocampal synapses
por: Nishant Singh, et al.
Publicado: (2021) -
Presenilin/γ-secretase regulates neurexin processing at synapses.
por: Carlos A Saura, et al.
Publicado: (2011)