Updates in the Language of <italic toggle="yes">Histoplasma</italic> Biodiversity

ABSTRACT In a recent article, Sepúlveda et al. (mBio 8:e01339-17, 2017, https://doi.org/10.1128/mBio.01339-17) investigated the genetic structure and evolutionary history of the human pathogen Histoplasma. Using whole-genome resequencing data, Sepúlveda et al. found that the Histoplasma genus is com...

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Autor principal:	Pierre Gladieux
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	fungi gene flow genomics pathogens speciation systematics Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/9143757a557f45d6bfaa3951df1e0ec0
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spelling	oai:doaj.org-article:9143757a557f45d6bfaa3951df1e0ec02021-11-15T16:00:27ZUpdates in the Language of <italic toggle="yes">Histoplasma</italic> Biodiversity10.1128/mBio.00181-182150-7511https://doaj.org/article/9143757a557f45d6bfaa3951df1e0ec02018-07-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00181-18https://doaj.org/toc/2150-7511ABSTRACT In a recent article, Sepúlveda et al. (mBio 8:e01339-17, 2017, https://doi.org/10.1128/mBio.01339-17) investigated the genetic structure and evolutionary history of the human pathogen Histoplasma. Using whole-genome resequencing data, Sepúlveda et al. found that the Histoplasma genus is composed of at least four strongly differentiated lineages. Their tour de force is to use a smart combination of population genomic approaches to show that the advanced stage of intraspecific divergence observed within Histoplasma does not simply reflect population structure, but instead results from previously unidentified speciation events. The four independently evolving Histoplasma lineages are elevated to the species status and assigned names. The newly described species exhibit medically important differences in phenotype, and these findings, therefore, have important epidemiological implications. This work provides a blueprint for phylogenomic species recognition in fungi, opening the way for a new age of enlightenment in which fungal species are diagnosed using highly discriminatory tools within a hypothesis-testing framework.Pierre GladieuxAmerican Society for Microbiologyarticlefungigene flowgenomicspathogensspeciationsystematicsMicrobiologyQR1-502ENmBio, Vol 9, Iss 3 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	fungi gene flow genomics pathogens speciation systematics Microbiology QR1-502
spellingShingle	fungi gene flow genomics pathogens speciation systematics Microbiology QR1-502 Pierre Gladieux Updates in the Language of <italic toggle="yes">Histoplasma</italic> Biodiversity
description	ABSTRACT In a recent article, Sepúlveda et al. (mBio 8:e01339-17, 2017, https://doi.org/10.1128/mBio.01339-17) investigated the genetic structure and evolutionary history of the human pathogen Histoplasma. Using whole-genome resequencing data, Sepúlveda et al. found that the Histoplasma genus is composed of at least four strongly differentiated lineages. Their tour de force is to use a smart combination of population genomic approaches to show that the advanced stage of intraspecific divergence observed within Histoplasma does not simply reflect population structure, but instead results from previously unidentified speciation events. The four independently evolving Histoplasma lineages are elevated to the species status and assigned names. The newly described species exhibit medically important differences in phenotype, and these findings, therefore, have important epidemiological implications. This work provides a blueprint for phylogenomic species recognition in fungi, opening the way for a new age of enlightenment in which fungal species are diagnosed using highly discriminatory tools within a hypothesis-testing framework.
format	article
author	Pierre Gladieux
author_facet	Pierre Gladieux
author_sort	Pierre Gladieux
title	Updates in the Language of <italic toggle="yes">Histoplasma</italic> Biodiversity
title_short	Updates in the Language of <italic toggle="yes">Histoplasma</italic> Biodiversity
title_full	Updates in the Language of <italic toggle="yes">Histoplasma</italic> Biodiversity
title_fullStr	Updates in the Language of <italic toggle="yes">Histoplasma</italic> Biodiversity
title_full_unstemmed	Updates in the Language of <italic toggle="yes">Histoplasma</italic> Biodiversity
title_sort	updates in the language of <italic toggle="yes">histoplasma</italic> biodiversity
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/9143757a557f45d6bfaa3951df1e0ec0
work_keys_str_mv	AT pierregladieux updatesinthelanguageofitalictoggleyeshistoplasmaitalicbiodiversity
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Updates in the Language of <italic toggle="yes">Histoplasma</italic> Biodiversity

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