METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N 6-methyladenosine-dependent YTHDF binding

The epitranscriptomic regulation of adenomatous polyposis coli (APC) tumour suppressor gene in cancers is unclear. Here the authors show that N6-methyladenosine methylation writer METTL3 downregulates APC by recruiting YTHDF2 for APC mRNA degradation, and that this promotes glycolysis and tumour gro...

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Autores principales:	Wei Wang, Fei Shao, Xueying Yang, Juhong Wang, Rongxuan Zhu, Yannan Yang, Gaoxiang Zhao, Dong Guo, Yingli Sun, Jie Wang, Qi Xue, Shugeng Gao, Yibo Gao, Jie He, Zhimin Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9143dfce7dc541c4be4f82d7735868d7
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spelling	oai:doaj.org-article:9143dfce7dc541c4be4f82d7735868d72021-12-02T16:06:02ZMETTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N 6-methyladenosine-dependent YTHDF binding10.1038/s41467-021-23501-52041-1723https://doaj.org/article/9143dfce7dc541c4be4f82d7735868d72021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23501-5https://doaj.org/toc/2041-1723The epitranscriptomic regulation of adenomatous polyposis coli (APC) tumour suppressor gene in cancers is unclear. Here the authors show that N6-methyladenosine methylation writer METTL3 downregulates APC by recruiting YTHDF2 for APC mRNA degradation, and that this promotes glycolysis and tumour growth in oesophageal cancers.Wei WangFei ShaoXueying YangJuhong WangRongxuan ZhuYannan YangGaoxiang ZhaoDong GuoYingli SunJie WangQi XueShugeng GaoYibo GaoJie HeZhimin LuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wei Wang Fei Shao Xueying Yang Juhong Wang Rongxuan Zhu Yannan Yang Gaoxiang Zhao Dong Guo Yingli Sun Jie Wang Qi Xue Shugeng Gao Yibo Gao Jie He Zhimin Lu METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N 6-methyladenosine-dependent YTHDF binding
description	The epitranscriptomic regulation of adenomatous polyposis coli (APC) tumour suppressor gene in cancers is unclear. Here the authors show that N6-methyladenosine methylation writer METTL3 downregulates APC by recruiting YTHDF2 for APC mRNA degradation, and that this promotes glycolysis and tumour growth in oesophageal cancers.
format	article
author	Wei Wang Fei Shao Xueying Yang Juhong Wang Rongxuan Zhu Yannan Yang Gaoxiang Zhao Dong Guo Yingli Sun Jie Wang Qi Xue Shugeng Gao Yibo Gao Jie He Zhimin Lu
author_facet	Wei Wang Fei Shao Xueying Yang Juhong Wang Rongxuan Zhu Yannan Yang Gaoxiang Zhao Dong Guo Yingli Sun Jie Wang Qi Xue Shugeng Gao Yibo Gao Jie He Zhimin Lu
author_sort	Wei Wang
title	METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N 6-methyladenosine-dependent YTHDF binding
title_short	METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N 6-methyladenosine-dependent YTHDF binding
title_full	METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N 6-methyladenosine-dependent YTHDF binding
title_fullStr	METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N 6-methyladenosine-dependent YTHDF binding
title_full_unstemmed	METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N 6-methyladenosine-dependent YTHDF binding
title_sort	mettl3 promotes tumour development by decreasing apc expression mediated by apc mrna n 6-methyladenosine-dependent ythdf binding
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9143dfce7dc541c4be4f82d7735868d7
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METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N 6-methyladenosine-dependent YTHDF binding

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