High Moesin Expression Is a Predictor of Poor Prognosis of Breast Cancer: Evidence From a Systematic Review With Meta-Analysis
Owing to metastases and drug resistance, the prognosis of breast cancer is still dismal. Therefore, it is necessary to find new prognostic markers to improve the efficacy of breast cancer treatment. Literature shows a controversy between moesin (MSN) expression and prognosis in breast cancer. Here,...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:91476c6ba7994e6f9162414a64c054c62021-12-01T04:24:02ZHigh Moesin Expression Is a Predictor of Poor Prognosis of Breast Cancer: Evidence From a Systematic Review With Meta-Analysis2234-943X10.3389/fonc.2021.650488https://doaj.org/article/91476c6ba7994e6f9162414a64c054c62021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.650488/fullhttps://doaj.org/toc/2234-943XOwing to metastases and drug resistance, the prognosis of breast cancer is still dismal. Therefore, it is necessary to find new prognostic markers to improve the efficacy of breast cancer treatment. Literature shows a controversy between moesin (MSN) expression and prognosis in breast cancer. Here, we aimed to conduct a systematic review and meta-analysis to evaluate the prognostic relationship between MSN and breast cancer. Literature retrieval was conducted in the following databases: PubMed, Web of Science, Embase, and Cochrane. Two reviewers independently performed the screening of studies and data extraction. The Gene Expression Omnibus (GEO) database including both breast cancer gene expression and follow-up datasets was selected to verify literature results. The R software was employed for the meta-analysis. A total of 9 articles with 3,039 patients and 16 datasets with 2,916 patients were ultimately included. Results indicated that there was a significant relationship between MSN and lymph node metastases (P < 0.05), and high MSN expression was associated with poor outcome of breast cancer patients (HR = 1.99; 95% CI 1.73–2.24). In summary, there is available evidence to support that high MSN expression has valuable importance for the poor prognosis in breast cancer patients.Systematic Review Registrationhttps://inplasy.com/inplasy-2020-8-0039/.Xiaoli HuXiaoli HuXiaoli HuXiaoli HuXiaoli HuYang LiuYang LiuYang LiuYang LiuYang LiuZhitong BingQian YeQian YeQian YeQian YeChengcheng LiFrontiers Media S.A.articleMSNlymph node metastasisprognosisbreast cancermeta-analysisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021) |
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EN |
| topic |
MSN lymph node metastasis prognosis breast cancer meta-analysis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
| spellingShingle |
MSN lymph node metastasis prognosis breast cancer meta-analysis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Xiaoli Hu Xiaoli Hu Xiaoli Hu Xiaoli Hu Xiaoli Hu Yang Liu Yang Liu Yang Liu Yang Liu Yang Liu Zhitong Bing Qian Ye Qian Ye Qian Ye Qian Ye Chengcheng Li High Moesin Expression Is a Predictor of Poor Prognosis of Breast Cancer: Evidence From a Systematic Review With Meta-Analysis |
| description |
Owing to metastases and drug resistance, the prognosis of breast cancer is still dismal. Therefore, it is necessary to find new prognostic markers to improve the efficacy of breast cancer treatment. Literature shows a controversy between moesin (MSN) expression and prognosis in breast cancer. Here, we aimed to conduct a systematic review and meta-analysis to evaluate the prognostic relationship between MSN and breast cancer. Literature retrieval was conducted in the following databases: PubMed, Web of Science, Embase, and Cochrane. Two reviewers independently performed the screening of studies and data extraction. The Gene Expression Omnibus (GEO) database including both breast cancer gene expression and follow-up datasets was selected to verify literature results. The R software was employed for the meta-analysis. A total of 9 articles with 3,039 patients and 16 datasets with 2,916 patients were ultimately included. Results indicated that there was a significant relationship between MSN and lymph node metastases (P < 0.05), and high MSN expression was associated with poor outcome of breast cancer patients (HR = 1.99; 95% CI 1.73–2.24). In summary, there is available evidence to support that high MSN expression has valuable importance for the poor prognosis in breast cancer patients.Systematic Review Registrationhttps://inplasy.com/inplasy-2020-8-0039/. |
| format |
article |
| author |
Xiaoli Hu Xiaoli Hu Xiaoli Hu Xiaoli Hu Xiaoli Hu Yang Liu Yang Liu Yang Liu Yang Liu Yang Liu Zhitong Bing Qian Ye Qian Ye Qian Ye Qian Ye Chengcheng Li |
| author_facet |
Xiaoli Hu Xiaoli Hu Xiaoli Hu Xiaoli Hu Xiaoli Hu Yang Liu Yang Liu Yang Liu Yang Liu Yang Liu Zhitong Bing Qian Ye Qian Ye Qian Ye Qian Ye Chengcheng Li |
| author_sort |
Xiaoli Hu |
| title |
High Moesin Expression Is a Predictor of Poor Prognosis of Breast Cancer: Evidence From a Systematic Review With Meta-Analysis |
| title_short |
High Moesin Expression Is a Predictor of Poor Prognosis of Breast Cancer: Evidence From a Systematic Review With Meta-Analysis |
| title_full |
High Moesin Expression Is a Predictor of Poor Prognosis of Breast Cancer: Evidence From a Systematic Review With Meta-Analysis |
| title_fullStr |
High Moesin Expression Is a Predictor of Poor Prognosis of Breast Cancer: Evidence From a Systematic Review With Meta-Analysis |
| title_full_unstemmed |
High Moesin Expression Is a Predictor of Poor Prognosis of Breast Cancer: Evidence From a Systematic Review With Meta-Analysis |
| title_sort |
high moesin expression is a predictor of poor prognosis of breast cancer: evidence from a systematic review with meta-analysis |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/91476c6ba7994e6f9162414a64c054c6 |
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