Effects of crosslinking on the physical solid-state and dissolution properties of 3D-printed theophylline tablets

Crosslinking is an established treatment to alter the physicochemical and functional properties of polymers through the creation of bonds between the polymer chains. Polymers can be crosslinked via radiation in the presence of photo-initiator. The aim of the present study was to formulate 3D-printed...

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Autores principales:	Hele Anderspuk, Laura Viidik, Kristjan Olado, Karin Kogermann, Anne Juppo, Jyrki Heinämäki, Ivo Laidmäe
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	3D-printing UV-crosslinking Gamma-radiation crosslinking Drug release Polyethylene oxide Theophylline Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/914922e9c2c347c183df488e503e2acb
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spelling	oai:doaj.org-article:914922e9c2c347c183df488e503e2acb2021-11-18T04:53:42ZEffects of crosslinking on the physical solid-state and dissolution properties of 3D-printed theophylline tablets2666-964110.1016/j.stlm.2021.100031https://doaj.org/article/914922e9c2c347c183df488e503e2acb2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2666964121000266https://doaj.org/toc/2666-9641Crosslinking is an established treatment to alter the physicochemical and functional properties of polymers through the creation of bonds between the polymer chains. Polymers can be crosslinked via radiation in the presence of photo-initiator. The aim of the present study was to formulate 3D-printed theophylline (THEO) tablets using polyethylene oxide (PEO) as a carrier polymer, and to study the influence of crosslinking on the drug release behavior. The tablets were 3D-printed using the aqueous solution of PEO and THEO (80:20 w/w) with a micro-extrusion-based printing setup. A photo-initiator (4-hydroxybenzophenone) was added into the printing solutions, and the injectability of the solutions was investigated prior to printing. The 3D-printed tablets were crosslinked after printing using ultraviolet (UV) or gamma-radiation, and crosslinking was verified by means of Fourier-transform infrared (FTIR) spectroscopy. The maximum injection force of aqueous printing solutions of PEO and THEO was close to that observed with the pure PEO solution. Increasing the number of printing layers in the 3D-printed tablets resulted in a slower drug release in vitro. Gamma-radiation in a nitrogen environment and UV-crosslinking made the carrier polymer (PEO) less water-soluble, but such crosslinking did not affect the release rate of the tablets. Surprisingly, even faster drug release behavior was found with the crosslinked 3D-printed tablets compared to that of non-crosslinked tablets. More research work is needed on the impact of 3D-printed tablet layering thickness and crosslinking for tailoring drug release behavior.Hele AnderspukLaura ViidikKristjan OladoKarin KogermannAnne JuppoJyrki HeinämäkiIvo LaidmäeElsevierarticle3D-printingUV-crosslinkingGamma-radiation crosslinkingDrug releasePolyethylene oxideTheophyllineMedical technologyR855-855.5ENAnnals of 3D Printed Medicine, Vol 4, Iss , Pp 100031- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	3D-printing UV-crosslinking Gamma-radiation crosslinking Drug release Polyethylene oxide Theophylline Medical technology R855-855.5
spellingShingle	3D-printing UV-crosslinking Gamma-radiation crosslinking Drug release Polyethylene oxide Theophylline Medical technology R855-855.5 Hele Anderspuk Laura Viidik Kristjan Olado Karin Kogermann Anne Juppo Jyrki Heinämäki Ivo Laidmäe Effects of crosslinking on the physical solid-state and dissolution properties of 3D-printed theophylline tablets
description	Crosslinking is an established treatment to alter the physicochemical and functional properties of polymers through the creation of bonds between the polymer chains. Polymers can be crosslinked via radiation in the presence of photo-initiator. The aim of the present study was to formulate 3D-printed theophylline (THEO) tablets using polyethylene oxide (PEO) as a carrier polymer, and to study the influence of crosslinking on the drug release behavior. The tablets were 3D-printed using the aqueous solution of PEO and THEO (80:20 w/w) with a micro-extrusion-based printing setup. A photo-initiator (4-hydroxybenzophenone) was added into the printing solutions, and the injectability of the solutions was investigated prior to printing. The 3D-printed tablets were crosslinked after printing using ultraviolet (UV) or gamma-radiation, and crosslinking was verified by means of Fourier-transform infrared (FTIR) spectroscopy. The maximum injection force of aqueous printing solutions of PEO and THEO was close to that observed with the pure PEO solution. Increasing the number of printing layers in the 3D-printed tablets resulted in a slower drug release in vitro. Gamma-radiation in a nitrogen environment and UV-crosslinking made the carrier polymer (PEO) less water-soluble, but such crosslinking did not affect the release rate of the tablets. Surprisingly, even faster drug release behavior was found with the crosslinked 3D-printed tablets compared to that of non-crosslinked tablets. More research work is needed on the impact of 3D-printed tablet layering thickness and crosslinking for tailoring drug release behavior.
format	article
author	Hele Anderspuk Laura Viidik Kristjan Olado Karin Kogermann Anne Juppo Jyrki Heinämäki Ivo Laidmäe
author_facet	Hele Anderspuk Laura Viidik Kristjan Olado Karin Kogermann Anne Juppo Jyrki Heinämäki Ivo Laidmäe
author_sort	Hele Anderspuk
title	Effects of crosslinking on the physical solid-state and dissolution properties of 3D-printed theophylline tablets
title_short	Effects of crosslinking on the physical solid-state and dissolution properties of 3D-printed theophylline tablets
title_full	Effects of crosslinking on the physical solid-state and dissolution properties of 3D-printed theophylline tablets
title_fullStr	Effects of crosslinking on the physical solid-state and dissolution properties of 3D-printed theophylline tablets
title_full_unstemmed	Effects of crosslinking on the physical solid-state and dissolution properties of 3D-printed theophylline tablets
title_sort	effects of crosslinking on the physical solid-state and dissolution properties of 3d-printed theophylline tablets
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/914922e9c2c347c183df488e503e2acb
work_keys_str_mv	AT heleanderspuk effectsofcrosslinkingonthephysicalsolidstateanddissolutionpropertiesof3dprintedtheophyllinetablets AT lauraviidik effectsofcrosslinkingonthephysicalsolidstateanddissolutionpropertiesof3dprintedtheophyllinetablets AT kristjanolado effectsofcrosslinkingonthephysicalsolidstateanddissolutionpropertiesof3dprintedtheophyllinetablets AT karinkogermann effectsofcrosslinkingonthephysicalsolidstateanddissolutionpropertiesof3dprintedtheophyllinetablets AT annejuppo effectsofcrosslinkingonthephysicalsolidstateanddissolutionpropertiesof3dprintedtheophyllinetablets AT jyrkiheinamaki effectsofcrosslinkingonthephysicalsolidstateanddissolutionpropertiesof3dprintedtheophyllinetablets AT ivolaidmae effectsofcrosslinkingonthephysicalsolidstateanddissolutionpropertiesof3dprintedtheophyllinetablets
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Effects of crosslinking on the physical solid-state and dissolution properties of 3D-printed theophylline tablets

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