Effect of Anthocyanins Supplementation on Serum IGFBP-4 Fragments and Glycemic Control in Patients with Fasting Hyperglycemia: A Randomized Controlled Trial

Liping Yang,1,2 Zhaomin Liu,2 Wenhua Ling,2 Li Wang,1 Changyi Wang,1 Jianping Ma,1 Xiaolin Peng,1 Jianying Chen3 1Center for Chronic Disease Control, Nanshan, Shenzhen, People’s Republic of China; 2Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition,...

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Autores principales:	Yang L, Liu Z, Ling W, Wang L, Wang C, Ma J, Peng X, Chen J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	igfbp-4 fragments anthocyanin oral glucose tolerance test insulin resistance c-peptide. Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/914ce3996e1a455c92ed2c2666089844
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spelling	oai:doaj.org-article:914ce3996e1a455c92ed2c26660898442021-12-02T11:10:58ZEffect of Anthocyanins Supplementation on Serum IGFBP-4 Fragments and Glycemic Control in Patients with Fasting Hyperglycemia: A Randomized Controlled Trial1178-7007https://doaj.org/article/914ce3996e1a455c92ed2c26660898442020-09-01T00:00:00Zhttps://www.dovepress.com/effect-of-anthocyanins-supplementation-on-serum-igfbp-4-fragments-and--peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Liping Yang,1,2 Zhaomin Liu,2 Wenhua Ling,2 Li Wang,1 Changyi Wang,1 Jianping Ma,1 Xiaolin Peng,1 Jianying Chen3 1Center for Chronic Disease Control, Nanshan, Shenzhen, People’s Republic of China; 2Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, People’s Republic of China; 3Internal Medicine Department, BaiYun Hospital, GuangZhou, GuangDong Province, People’s Republic of ChinaCorrespondence: Liping YangCenter for Chronic Disease Control, NanShan, ShenZhen 518000, People’s Republic of ChinaTel +86-755-26403300Email yanglp6@mail2.sysu.edu.cnBackground: Insulin-like growth factor binding protein-4 (IGFBP-4) fragments have been shown to be associated with cardiometabolic diseases. Anthocyanins as a subgroup of natural polyphenols could have benefits on treating cardiometabolic diseases. The aim of this study was to examine the effects of purified anthocyanins on serum IGFBP-4 fragments and glycemic control in patients with fasting hyperglycemia.Methods: A set of 121 participants with elevated fasting glucose (≥ 5.6 mmol/L), who were originally randomly assigned to anthocyanins (320 mg/day) or placebo groups, were included in this study. Serum IGFBP-4 fragments, fasting and postload glucose, insulin, and C-peptide after a three-hour oral glucose tolerance test (OGTT) were measured at baseline and at the end of 12 weeks.Results: Compared with placebo, anthocyanins increased serum IGFBP-4 fragments (net change 8.33 ng/mL, 95% CI [1.2, 15.47], p=0.023) and decreased fasting glucose (− 0.4 mmol/L [− 0.71, -0.1], p=0.01), 2-hour C-peptide (− 1.02 ng/mL [− 1.99, − 0.04], p=0.041) and the 3-hour area under the curve (AUC) of C-peptide (− 2.19 [− 4.11, − 0.27], p=0.026). No other significant difference in parameters for glycemic control and insulin resistance was observed.Conclusion: Anthocyanins supplementation for 12 weeks improved serum IGFBP-4 fragments and decreased fasting glucose and postload C-peptide in patients with fasting hyperglycemia. Further studies are needed to confirm our findings and clarify the potential mechanism.Trial Registration: ClinicalTrials.gov, NCT02689765. Registered on 6 February 2016, https://clinicaltrials.gov/ct2/show/NCT02689765.Keywords: IGFBP-4 fragments, anthocyanin, oral glucose tolerance test, insulin resistance, C-peptideYang LLiu ZLing WWang LWang CMa JPeng XChen JDove Medical Pressarticleigfbp-4 fragmentsanthocyaninoral glucose tolerance testinsulin resistancec-peptide.Specialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 3395-3404 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	igfbp-4 fragments anthocyanin oral glucose tolerance test insulin resistance c-peptide. Specialties of internal medicine RC581-951
spellingShingle	igfbp-4 fragments anthocyanin oral glucose tolerance test insulin resistance c-peptide. Specialties of internal medicine RC581-951 Yang L Liu Z Ling W Wang L Wang C Ma J Peng X Chen J Effect of Anthocyanins Supplementation on Serum IGFBP-4 Fragments and Glycemic Control in Patients with Fasting Hyperglycemia: A Randomized Controlled Trial
description	Liping Yang,1,2 Zhaomin Liu,2 Wenhua Ling,2 Li Wang,1 Changyi Wang,1 Jianping Ma,1 Xiaolin Peng,1 Jianying Chen3 1Center for Chronic Disease Control, Nanshan, Shenzhen, People’s Republic of China; 2Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, People’s Republic of China; 3Internal Medicine Department, BaiYun Hospital, GuangZhou, GuangDong Province, People’s Republic of ChinaCorrespondence: Liping YangCenter for Chronic Disease Control, NanShan, ShenZhen 518000, People’s Republic of ChinaTel +86-755-26403300Email yanglp6@mail2.sysu.edu.cnBackground: Insulin-like growth factor binding protein-4 (IGFBP-4) fragments have been shown to be associated with cardiometabolic diseases. Anthocyanins as a subgroup of natural polyphenols could have benefits on treating cardiometabolic diseases. The aim of this study was to examine the effects of purified anthocyanins on serum IGFBP-4 fragments and glycemic control in patients with fasting hyperglycemia.Methods: A set of 121 participants with elevated fasting glucose (≥ 5.6 mmol/L), who were originally randomly assigned to anthocyanins (320 mg/day) or placebo groups, were included in this study. Serum IGFBP-4 fragments, fasting and postload glucose, insulin, and C-peptide after a three-hour oral glucose tolerance test (OGTT) were measured at baseline and at the end of 12 weeks.Results: Compared with placebo, anthocyanins increased serum IGFBP-4 fragments (net change 8.33 ng/mL, 95% CI [1.2, 15.47], p=0.023) and decreased fasting glucose (− 0.4 mmol/L [− 0.71, -0.1], p=0.01), 2-hour C-peptide (− 1.02 ng/mL [− 1.99, − 0.04], p=0.041) and the 3-hour area under the curve (AUC) of C-peptide (− 2.19 [− 4.11, − 0.27], p=0.026). No other significant difference in parameters for glycemic control and insulin resistance was observed.Conclusion: Anthocyanins supplementation for 12 weeks improved serum IGFBP-4 fragments and decreased fasting glucose and postload C-peptide in patients with fasting hyperglycemia. Further studies are needed to confirm our findings and clarify the potential mechanism.Trial Registration: ClinicalTrials.gov, NCT02689765. Registered on 6 February 2016, https://clinicaltrials.gov/ct2/show/NCT02689765.Keywords: IGFBP-4 fragments, anthocyanin, oral glucose tolerance test, insulin resistance, C-peptide
format	article
author	Yang L Liu Z Ling W Wang L Wang C Ma J Peng X Chen J
author_facet	Yang L Liu Z Ling W Wang L Wang C Ma J Peng X Chen J
author_sort	Yang L
title	Effect of Anthocyanins Supplementation on Serum IGFBP-4 Fragments and Glycemic Control in Patients with Fasting Hyperglycemia: A Randomized Controlled Trial
title_short	Effect of Anthocyanins Supplementation on Serum IGFBP-4 Fragments and Glycemic Control in Patients with Fasting Hyperglycemia: A Randomized Controlled Trial
title_full	Effect of Anthocyanins Supplementation on Serum IGFBP-4 Fragments and Glycemic Control in Patients with Fasting Hyperglycemia: A Randomized Controlled Trial
title_fullStr	Effect of Anthocyanins Supplementation on Serum IGFBP-4 Fragments and Glycemic Control in Patients with Fasting Hyperglycemia: A Randomized Controlled Trial
title_full_unstemmed	Effect of Anthocyanins Supplementation on Serum IGFBP-4 Fragments and Glycemic Control in Patients with Fasting Hyperglycemia: A Randomized Controlled Trial
title_sort	effect of anthocyanins supplementation on serum igfbp-4 fragments and glycemic control in patients with fasting hyperglycemia: a randomized controlled trial
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/914ce3996e1a455c92ed2c2666089844
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Effect of Anthocyanins Supplementation on Serum IGFBP-4 Fragments and Glycemic Control in Patients with Fasting Hyperglycemia: A Randomized Controlled Trial

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