Development of colorectal cancer predicts increased risk of subsequent hepatocellular carcinoma in patients with alcoholic liver disease: case-control and cohort study

Abstract Alcohol increases the risk of both hepatocellular carcinoma (HCC) and colorectal neoplasia. In this hospital-based case-control and retrospective cohort study, we sought to determine whether development of colorectal neoplasia increases the risk of HCC in patients with alcoholic liver disea...

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Autores principales:	Won Kim, Dongjae Jeong, Jungwha Chung, Donghyeon Lee, Saekyoung Joo, Eun Sun Jang, Yoon Jin Choi, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Sook-Hyang Jeong, Nayoung Kim, Dong Ho Lee, Jin-Wook Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/914e274151d14a31afdd405ce0cc7f5f
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spelling	oai:doaj.org-article:914e274151d14a31afdd405ce0cc7f5f2021-12-02T15:09:45ZDevelopment of colorectal cancer predicts increased risk of subsequent hepatocellular carcinoma in patients with alcoholic liver disease: case-control and cohort study10.1038/s41598-019-39573-92045-2322https://doaj.org/article/914e274151d14a31afdd405ce0cc7f5f2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-39573-9https://doaj.org/toc/2045-2322Abstract Alcohol increases the risk of both hepatocellular carcinoma (HCC) and colorectal neoplasia. In this hospital-based case-control and retrospective cohort study, we sought to determine whether development of colorectal neoplasia increases the risk of HCC in patients with alcoholic liver disease (ALD). In the phase I case-control analysis, the association between history of colorectal cancer (CRC) and HCC development was assessed in patients with ALD by logistic regression modeling (n = 1,659). In the phase II retrospective cohort analysis, the relative risk of HCC development was compared in ALD patients with respect to the history of CRC by a Cox model (n = 1,184). The history of CRC was significantly associated with HCC in the case-control analysis (adjusted odds ratio, 1.82; 95% CI, 1.06–3.15; P < 0.05). ALD patients with CRC had higher risk of developing HCC compared to those without CRC (adjusted hazards ratio [HR], 5.48; 95% CI, 1.63–18.36; P = 0.006) in the cohort analysis. Presence of CRC, liver cirrhosis, elevated baseline alpha-fetoprotein level, and low platelet counts were independent predictors of HCC development in ALD patients. Patients with history of CRC had an increased risk of HCC in both cirrhotic (HR, 3.76; 95% CI, 1.05–13.34, P = 0.041) and non-cirrhotic (HR, 23.46; 95% CI, 2.81–195.83, P = 0.004) ALD patients. In conclusion, ALD patients with CRC are at increased risk of developing HCC.Won KimDongjae JeongJungwha ChungDonghyeon LeeSaekyoung JooEun Sun JangYoon Jin ChoiHyuk YoonCheol Min ShinYoung Soo ParkSook-Hyang JeongNayoung KimDong Ho LeeJin-Wook KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Won Kim Dongjae Jeong Jungwha Chung Donghyeon Lee Saekyoung Joo Eun Sun Jang Yoon Jin Choi Hyuk Yoon Cheol Min Shin Young Soo Park Sook-Hyang Jeong Nayoung Kim Dong Ho Lee Jin-Wook Kim Development of colorectal cancer predicts increased risk of subsequent hepatocellular carcinoma in patients with alcoholic liver disease: case-control and cohort study
description	Abstract Alcohol increases the risk of both hepatocellular carcinoma (HCC) and colorectal neoplasia. In this hospital-based case-control and retrospective cohort study, we sought to determine whether development of colorectal neoplasia increases the risk of HCC in patients with alcoholic liver disease (ALD). In the phase I case-control analysis, the association between history of colorectal cancer (CRC) and HCC development was assessed in patients with ALD by logistic regression modeling (n = 1,659). In the phase II retrospective cohort analysis, the relative risk of HCC development was compared in ALD patients with respect to the history of CRC by a Cox model (n = 1,184). The history of CRC was significantly associated with HCC in the case-control analysis (adjusted odds ratio, 1.82; 95% CI, 1.06–3.15; P < 0.05). ALD patients with CRC had higher risk of developing HCC compared to those without CRC (adjusted hazards ratio [HR], 5.48; 95% CI, 1.63–18.36; P = 0.006) in the cohort analysis. Presence of CRC, liver cirrhosis, elevated baseline alpha-fetoprotein level, and low platelet counts were independent predictors of HCC development in ALD patients. Patients with history of CRC had an increased risk of HCC in both cirrhotic (HR, 3.76; 95% CI, 1.05–13.34, P = 0.041) and non-cirrhotic (HR, 23.46; 95% CI, 2.81–195.83, P = 0.004) ALD patients. In conclusion, ALD patients with CRC are at increased risk of developing HCC.
format	article
author	Won Kim Dongjae Jeong Jungwha Chung Donghyeon Lee Saekyoung Joo Eun Sun Jang Yoon Jin Choi Hyuk Yoon Cheol Min Shin Young Soo Park Sook-Hyang Jeong Nayoung Kim Dong Ho Lee Jin-Wook Kim
author_facet	Won Kim Dongjae Jeong Jungwha Chung Donghyeon Lee Saekyoung Joo Eun Sun Jang Yoon Jin Choi Hyuk Yoon Cheol Min Shin Young Soo Park Sook-Hyang Jeong Nayoung Kim Dong Ho Lee Jin-Wook Kim
author_sort	Won Kim
title	Development of colorectal cancer predicts increased risk of subsequent hepatocellular carcinoma in patients with alcoholic liver disease: case-control and cohort study
title_short	Development of colorectal cancer predicts increased risk of subsequent hepatocellular carcinoma in patients with alcoholic liver disease: case-control and cohort study
title_full	Development of colorectal cancer predicts increased risk of subsequent hepatocellular carcinoma in patients with alcoholic liver disease: case-control and cohort study
title_fullStr	Development of colorectal cancer predicts increased risk of subsequent hepatocellular carcinoma in patients with alcoholic liver disease: case-control and cohort study
title_full_unstemmed	Development of colorectal cancer predicts increased risk of subsequent hepatocellular carcinoma in patients with alcoholic liver disease: case-control and cohort study
title_sort	development of colorectal cancer predicts increased risk of subsequent hepatocellular carcinoma in patients with alcoholic liver disease: case-control and cohort study
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/914e274151d14a31afdd405ce0cc7f5f
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Development of colorectal cancer predicts increased risk of subsequent hepatocellular carcinoma in patients with alcoholic liver disease: case-control and cohort study

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