IMMUNOHISTOCHEMICAL EXPRESSION OF GLYPICAN-3 IN HEPATOCELLULAR CARCINOMA

Objective: To determine the frequency of immunohistochemically expression of Glypican-3 in hepatocellular carcinoma on liver biopsies. Study Design: Descriptive cross-sectional study. Place and Duration of Study: Department of Histopathology, Armed Forces Institute of Pathology (AFIP), Rawalpindi,...

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Autores principales:	Dr Syed Salman Ali, Javeria Shaukat, Rabia Ahmed, Iqbal Muhammad
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2018
Materias:	glypican-3 hepatocellular carcinoma Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/9152dd23a334495089479df1201b436e
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spelling	oai:doaj.org-article:9152dd23a334495089479df1201b436e2021-12-03T07:15:59ZIMMUNOHISTOCHEMICAL EXPRESSION OF GLYPICAN-3 IN HEPATOCELLULAR CARCINOMA0030-96482411-8842https://doaj.org/article/9152dd23a334495089479df1201b436e2018-08-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/5/2https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine the frequency of immunohistochemically expression of Glypican-3 in hepatocellular carcinoma on liver biopsies. Study Design: Descriptive cross-sectional study. Place and Duration of Study: Department of Histopathology, Armed Forces Institute of Pathology (AFIP), Rawalpindi, from Jun 2015 to Jun 2016. Material and Methods: A total of 55 liver biopsies from the patients of hepatocellular carcinoma were included in the study. Age, gender, tumor grade and immunohistochemically expression of glypican-3 were noted. The data were analyzed by SPSS version 21. Mean and SD were calculated for numerical variables such as age. Percentages and frequencies were calculated for gender, tumor grade and immunohistochemically expression of glypican-3. The data collected for study were statistically analyzed using chi-square test. Results: Out of 55 patients of hepatocellular carcinoma, 44 (80%) were males and 11 (20%) were females. The age of the patients was between 41 and 80 years with an average age of 59.7 years and standard deviation of ± 8.8. Out of 55 cases, 32 cases (58.2%) were well differentiated, 18 cases (32.7%) were moderately differentiated and 5 cases (9.1%) were poorly differentiated. Forty-eight cases of hepatocellular carcinoma (87.3%) showed positivity for glypican-3 while 7 cases (12.7%) were negative. A significant statistical association was not seen among age, gender, tumor grade and glypican-3 expression, p-value being >0.05. Conclusion: The high expression of glypican-3 in hepatocellular carcinoma suggests its diagnostic utility and also its value in distinguishing hepatocellular carcinoma from other hepatic lesions. As antiglypican-3 therapy is currently under clinical evaluation, it might be useful as a therapeutic target in glypican-3 positive hepatocellular carcinoma cases.Dr Syed Salman AliJaveria ShaukatRabia AhmedIqbal MuhammadArmy Medical College Rawalpindiarticleglypican-3hepatocellular carcinomaMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 68, Iss 4, Pp 692-696 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	glypican-3 hepatocellular carcinoma Medicine R Medicine (General) R5-920
spellingShingle	glypican-3 hepatocellular carcinoma Medicine R Medicine (General) R5-920 Dr Syed Salman Ali Javeria Shaukat Rabia Ahmed Iqbal Muhammad IMMUNOHISTOCHEMICAL EXPRESSION OF GLYPICAN-3 IN HEPATOCELLULAR CARCINOMA
description	Objective: To determine the frequency of immunohistochemically expression of Glypican-3 in hepatocellular carcinoma on liver biopsies. Study Design: Descriptive cross-sectional study. Place and Duration of Study: Department of Histopathology, Armed Forces Institute of Pathology (AFIP), Rawalpindi, from Jun 2015 to Jun 2016. Material and Methods: A total of 55 liver biopsies from the patients of hepatocellular carcinoma were included in the study. Age, gender, tumor grade and immunohistochemically expression of glypican-3 were noted. The data were analyzed by SPSS version 21. Mean and SD were calculated for numerical variables such as age. Percentages and frequencies were calculated for gender, tumor grade and immunohistochemically expression of glypican-3. The data collected for study were statistically analyzed using chi-square test. Results: Out of 55 patients of hepatocellular carcinoma, 44 (80%) were males and 11 (20%) were females. The age of the patients was between 41 and 80 years with an average age of 59.7 years and standard deviation of ± 8.8. Out of 55 cases, 32 cases (58.2%) were well differentiated, 18 cases (32.7%) were moderately differentiated and 5 cases (9.1%) were poorly differentiated. Forty-eight cases of hepatocellular carcinoma (87.3%) showed positivity for glypican-3 while 7 cases (12.7%) were negative. A significant statistical association was not seen among age, gender, tumor grade and glypican-3 expression, p-value being >0.05. Conclusion: The high expression of glypican-3 in hepatocellular carcinoma suggests its diagnostic utility and also its value in distinguishing hepatocellular carcinoma from other hepatic lesions. As antiglypican-3 therapy is currently under clinical evaluation, it might be useful as a therapeutic target in glypican-3 positive hepatocellular carcinoma cases.
format	article
author	Dr Syed Salman Ali Javeria Shaukat Rabia Ahmed Iqbal Muhammad
author_facet	Dr Syed Salman Ali Javeria Shaukat Rabia Ahmed Iqbal Muhammad
author_sort	Dr Syed Salman Ali
title	IMMUNOHISTOCHEMICAL EXPRESSION OF GLYPICAN-3 IN HEPATOCELLULAR CARCINOMA
title_short	IMMUNOHISTOCHEMICAL EXPRESSION OF GLYPICAN-3 IN HEPATOCELLULAR CARCINOMA
title_full	IMMUNOHISTOCHEMICAL EXPRESSION OF GLYPICAN-3 IN HEPATOCELLULAR CARCINOMA
title_fullStr	IMMUNOHISTOCHEMICAL EXPRESSION OF GLYPICAN-3 IN HEPATOCELLULAR CARCINOMA
title_full_unstemmed	IMMUNOHISTOCHEMICAL EXPRESSION OF GLYPICAN-3 IN HEPATOCELLULAR CARCINOMA
title_sort	immunohistochemical expression of glypican-3 in hepatocellular carcinoma
publisher	Army Medical College Rawalpindi
publishDate	2018
url	https://doaj.org/article/9152dd23a334495089479df1201b436e
work_keys_str_mv	AT drsyedsalmanali immunohistochemicalexpressionofglypican3inhepatocellularcarcinoma AT javeriashaukat immunohistochemicalexpressionofglypican3inhepatocellularcarcinoma AT rabiaahmed immunohistochemicalexpressionofglypican3inhepatocellularcarcinoma AT iqbalmuhammad immunohistochemicalexpressionofglypican3inhepatocellularcarcinoma
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IMMUNOHISTOCHEMICAL EXPRESSION OF GLYPICAN-3 IN HEPATOCELLULAR CARCINOMA

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