Simulated Microgravity Subtlety Changes Monoamine Function across the Rat Brain

Microgravity, one of the conditions faced by astronauts during spaceflights, triggers brain adaptive responses that could have noxious consequences on behaviors. Although monoaminergic systems, which include noradrenaline (NA), dopamine (DA), and serotonin (5-HT), are widespread neuromodulatory syst...

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Autores principales:	Alexandra Gros, Léandre Lavenu, Jean-Luc Morel, Philippe De Deurwaerdère
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hindlimb unloading suspension dopamine noradrenaline serotonin neurochemistry system biology Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/915fad368b174ada9125a82de936d6fe
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spelling	oai:doaj.org-article:915fad368b174ada9125a82de936d6fe2021-11-11T17:12:54ZSimulated Microgravity Subtlety Changes Monoamine Function across the Rat Brain10.3390/ijms2221117591422-00671661-6596https://doaj.org/article/915fad368b174ada9125a82de936d6fe2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11759https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Microgravity, one of the conditions faced by astronauts during spaceflights, triggers brain adaptive responses that could have noxious consequences on behaviors. Although monoaminergic systems, which include noradrenaline (NA), dopamine (DA), and serotonin (5-HT), are widespread neuromodulatory systems involved in adaptive behaviors, the influence of microgravity on these systems is poorly documented. Using a model of simulated microgravity (SMG) during a short period in Long Evans male rats, we studied the distribution of monoamines in thirty brain regions belonging to vegetative, mood, motor, and cognitive networks. SMG modified NA and/or DA tissue contents along some brain regions belonging to the vestibular/motor systems (inferior olive, red nucleus, cerebellum, somatosensorily cortex, substantia nigra, and shell of the nucleus accumbens). DA and 5-HT contents were reduced in the prelimbic cortex, the only brain area exhibiting changes for 5-HT content. However, the number of correlations of one index of the 5-HT metabolism (ratio of metabolite and 5-HT) alone or in interaction with the DA metabolism was dramatically increased between brain regions. It is suggested that SMG, by mobilizing vestibular/motor systems, promotes in these systems early, restricted changes of NA and DA functions that are associated with a high reorganization of monoaminergic systems, notably 5-HT.Alexandra GrosLéandre LavenuJean-Luc MorelPhilippe De DeurwaerdèreMDPI AGarticlehindlimb unloading suspensiondopaminenoradrenalineserotoninneurochemistrysystem biologyBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11759, p 11759 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hindlimb unloading suspension dopamine noradrenaline serotonin neurochemistry system biology Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	hindlimb unloading suspension dopamine noradrenaline serotonin neurochemistry system biology Biology (General) QH301-705.5 Chemistry QD1-999 Alexandra Gros Léandre Lavenu Jean-Luc Morel Philippe De Deurwaerdère Simulated Microgravity Subtlety Changes Monoamine Function across the Rat Brain
description	Microgravity, one of the conditions faced by astronauts during spaceflights, triggers brain adaptive responses that could have noxious consequences on behaviors. Although monoaminergic systems, which include noradrenaline (NA), dopamine (DA), and serotonin (5-HT), are widespread neuromodulatory systems involved in adaptive behaviors, the influence of microgravity on these systems is poorly documented. Using a model of simulated microgravity (SMG) during a short period in Long Evans male rats, we studied the distribution of monoamines in thirty brain regions belonging to vegetative, mood, motor, and cognitive networks. SMG modified NA and/or DA tissue contents along some brain regions belonging to the vestibular/motor systems (inferior olive, red nucleus, cerebellum, somatosensorily cortex, substantia nigra, and shell of the nucleus accumbens). DA and 5-HT contents were reduced in the prelimbic cortex, the only brain area exhibiting changes for 5-HT content. However, the number of correlations of one index of the 5-HT metabolism (ratio of metabolite and 5-HT) alone or in interaction with the DA metabolism was dramatically increased between brain regions. It is suggested that SMG, by mobilizing vestibular/motor systems, promotes in these systems early, restricted changes of NA and DA functions that are associated with a high reorganization of monoaminergic systems, notably 5-HT.
format	article
author	Alexandra Gros Léandre Lavenu Jean-Luc Morel Philippe De Deurwaerdère
author_facet	Alexandra Gros Léandre Lavenu Jean-Luc Morel Philippe De Deurwaerdère
author_sort	Alexandra Gros
title	Simulated Microgravity Subtlety Changes Monoamine Function across the Rat Brain
title_short	Simulated Microgravity Subtlety Changes Monoamine Function across the Rat Brain
title_full	Simulated Microgravity Subtlety Changes Monoamine Function across the Rat Brain
title_fullStr	Simulated Microgravity Subtlety Changes Monoamine Function across the Rat Brain
title_full_unstemmed	Simulated Microgravity Subtlety Changes Monoamine Function across the Rat Brain
title_sort	simulated microgravity subtlety changes monoamine function across the rat brain
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/915fad368b174ada9125a82de936d6fe
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Simulated Microgravity Subtlety Changes Monoamine Function across the Rat Brain

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