Study of the effect of a new antiadhesive agent on peripheral blood indices (experimental study)

Adhesive process in the abdominal cavity was simulated in Wistar rats, which were divided into two groups: the main one - simulation of adhesive process in the abdominal cavity and introduction of 3 ml of saline into the abdominal cavity; the controls - simulation of adhesive process in the abdomina...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	M. G. Shurygina, N. I. Ayushinova, I. N. Kinash, E. E. Chepurnykh, M. G. Shurygin
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2017
Materias:	blood indices adhesions abdominal cavity Science Q
Acceso en línea:	https://doaj.org/article/915fd5e9249f490da45459f477b9dcbc
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:915fd5e9249f490da45459f477b9dcbc
record_format	dspace
spelling	oai:doaj.org-article:915fd5e9249f490da45459f477b9dcbc2021-11-23T06:14:37ZStudy of the effect of a new antiadhesive agent on peripheral blood indices (experimental study)2541-94202587-959610.12737/article_59f036060736c9.16043479https://doaj.org/article/915fd5e9249f490da45459f477b9dcbc2017-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/397https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Adhesive process in the abdominal cavity was simulated in Wistar rats, which were divided into two groups: the main one - simulation of adhesive process in the abdominal cavity and introduction of 3 ml of saline into the abdominal cavity; the controls - simulation of adhesive process in the abdominal cavity and introduction of 3 ml of new antiadhesive preparation. The mechanism of drug action bases on the ability to inhibit the growth of connective tissue in the adhesion area by effecting the activity of mitogen-activated protein kinases. Examination of peripheral blood indices was performed at eight time points during the period from 2 hours to 28 days. The concentration of red blood cells in the peripheral blood in both main and control groups decreased moderately in the early postoperative period (2 hours, 6 hours and 12 hours), and this rate was significantly lower in the control group as compared to the main one by 12 hours term. Later the index restored to normal. Hemoglobin concentration in the peripheral blood was higher in the main group than in the control one, the differences were significant in 2 hours, 3 days, 28 days. The level of hematocrit in the main group was higher than that in the controls during the entire follow-up period; the difference was maximal to the final term of experiment (28 days). The level of leukocytes in peripheral blood of the main group rats did not exceed the normal value for the given species of animals throughout the follow-up period. The number of eosinophils in the peripheral blood of the rodents of both groups did not differ at every period of survey. Thus, the introduction of the drug reduced the severity of leukocyte response to injury, improvement in postoperative hemoglobin and hematocrit levels.M. G. ShuryginaN. I. AyushinovaI. N. KinashE. E. ChepurnykhM. G. ShuryginScientific Сentre for Family Health and Human Reproduction Problemsarticleblood indicesadhesionsabdominal cavityScienceQRUActa Biomedica Scientifica, Vol 2, Iss 3, Pp 87-91 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	blood indices adhesions abdominal cavity Science Q
spellingShingle	blood indices adhesions abdominal cavity Science Q M. G. Shurygina N. I. Ayushinova I. N. Kinash E. E. Chepurnykh M. G. Shurygin Study of the effect of a new antiadhesive agent on peripheral blood indices (experimental study)
description	Adhesive process in the abdominal cavity was simulated in Wistar rats, which were divided into two groups: the main one - simulation of adhesive process in the abdominal cavity and introduction of 3 ml of saline into the abdominal cavity; the controls - simulation of adhesive process in the abdominal cavity and introduction of 3 ml of new antiadhesive preparation. The mechanism of drug action bases on the ability to inhibit the growth of connective tissue in the adhesion area by effecting the activity of mitogen-activated protein kinases. Examination of peripheral blood indices was performed at eight time points during the period from 2 hours to 28 days. The concentration of red blood cells in the peripheral blood in both main and control groups decreased moderately in the early postoperative period (2 hours, 6 hours and 12 hours), and this rate was significantly lower in the control group as compared to the main one by 12 hours term. Later the index restored to normal. Hemoglobin concentration in the peripheral blood was higher in the main group than in the control one, the differences were significant in 2 hours, 3 days, 28 days. The level of hematocrit in the main group was higher than that in the controls during the entire follow-up period; the difference was maximal to the final term of experiment (28 days). The level of leukocytes in peripheral blood of the main group rats did not exceed the normal value for the given species of animals throughout the follow-up period. The number of eosinophils in the peripheral blood of the rodents of both groups did not differ at every period of survey. Thus, the introduction of the drug reduced the severity of leukocyte response to injury, improvement in postoperative hemoglobin and hematocrit levels.
format	article
author	M. G. Shurygina N. I. Ayushinova I. N. Kinash E. E. Chepurnykh M. G. Shurygin
author_facet	M. G. Shurygina N. I. Ayushinova I. N. Kinash E. E. Chepurnykh M. G. Shurygin
author_sort	M. G. Shurygina
title	Study of the effect of a new antiadhesive agent on peripheral blood indices (experimental study)
title_short	Study of the effect of a new antiadhesive agent on peripheral blood indices (experimental study)
title_full	Study of the effect of a new antiadhesive agent on peripheral blood indices (experimental study)
title_fullStr	Study of the effect of a new antiadhesive agent on peripheral blood indices (experimental study)
title_full_unstemmed	Study of the effect of a new antiadhesive agent on peripheral blood indices (experimental study)
title_sort	study of the effect of a new antiadhesive agent on peripheral blood indices (experimental study)
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2017
url	https://doaj.org/article/915fd5e9249f490da45459f477b9dcbc
work_keys_str_mv	AT mgshurygina studyoftheeffectofanewantiadhesiveagentonperipheralbloodindicesexperimentalstudy AT niayushinova studyoftheeffectofanewantiadhesiveagentonperipheralbloodindicesexperimentalstudy AT inkinash studyoftheeffectofanewantiadhesiveagentonperipheralbloodindicesexperimentalstudy AT eechepurnykh studyoftheeffectofanewantiadhesiveagentonperipheralbloodindicesexperimentalstudy AT mgshurygin studyoftheeffectofanewantiadhesiveagentonperipheralbloodindicesexperimentalstudy
_version_	1718417021536829440

Study of the effect of a new antiadhesive agent on peripheral blood indices (experimental study)

Ejemplares similares