Kale supplementation during high fat feeding improves metabolic health in a mouse model of obesity and insulin resistance.

Cruciferous vegetables have been widely studied for cancer prevention and cardiovascular health. Broccoli is the cruciferous vegetable whose phytochemistry and physiological effects have been most extensively studied. Kale (Brassica oleracea var. acephala) appears on lists of 'healthiest, nutri...

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Autores principales:	Samnhita Raychaudhuri, Si Fan, Olivia Kraus, Md Shahinozzaman, Diana N Obanda
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9162a6fc7fcd46949402826cd09ee70e
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spelling	oai:doaj.org-article:9162a6fc7fcd46949402826cd09ee70e2021-12-02T20:19:34ZKale supplementation during high fat feeding improves metabolic health in a mouse model of obesity and insulin resistance.1932-620310.1371/journal.pone.0256348https://doaj.org/article/9162a6fc7fcd46949402826cd09ee70e2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256348https://doaj.org/toc/1932-6203Cruciferous vegetables have been widely studied for cancer prevention and cardiovascular health. Broccoli is the cruciferous vegetable whose phytochemistry and physiological effects have been most extensively studied. Kale (Brassica oleracea var. acephala) appears on lists of 'healthiest, nutrient dense foods' but, there is paucity of data on kale as a functional food. In a 12-week study, we tested the effect of curly green kale on high fat diet (HFD) induced obesity and insulin resistance, lipid metabolism, endotoxemia and inflammation in C57BL/6J mice fed isocaloric diets. Kale supplementation did not attenuate HFD diet induced fat accumulation and insulin resistance (P = ns; n = 9) but, it lowered serum triglycerides, low density lipoprotein (LPL) cholesterol and prevented HFD induced increases in systemic endotoxemia and inflammation (serum LPS and Ccl2) (P<0.01; n = 9). In adipose tissue, kale enhanced the expression of genes involved in adipogenesis (P<0.01; n = 9), reduced the appearance of histologic markers of inflammation, downregulated both the gene expression and protein expression of the adipose tissue specific inflammation markers CD11c and F4/80 (P<0.001; n = 9) and reduced the gene expression of a battery of chemokine C-C motif ligands (Ccl2, Ccl6, Ccl7, Ccl8, Ccl9) and chemokine C-C motif receptors (Ccr2, Ccr3, Ccr5). We conclude that kale vegetable protects against HFD diet induced dysfunction through mechanisms involving lipid metabolism, endotoxemia and inflammation.Samnhita RaychaudhuriSi FanOlivia KrausMd ShahinozzamanDiana N ObandaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0256348 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Samnhita Raychaudhuri Si Fan Olivia Kraus Md Shahinozzaman Diana N Obanda Kale supplementation during high fat feeding improves metabolic health in a mouse model of obesity and insulin resistance.
description	Cruciferous vegetables have been widely studied for cancer prevention and cardiovascular health. Broccoli is the cruciferous vegetable whose phytochemistry and physiological effects have been most extensively studied. Kale (Brassica oleracea var. acephala) appears on lists of 'healthiest, nutrient dense foods' but, there is paucity of data on kale as a functional food. In a 12-week study, we tested the effect of curly green kale on high fat diet (HFD) induced obesity and insulin resistance, lipid metabolism, endotoxemia and inflammation in C57BL/6J mice fed isocaloric diets. Kale supplementation did not attenuate HFD diet induced fat accumulation and insulin resistance (P = ns; n = 9) but, it lowered serum triglycerides, low density lipoprotein (LPL) cholesterol and prevented HFD induced increases in systemic endotoxemia and inflammation (serum LPS and Ccl2) (P<0.01; n = 9). In adipose tissue, kale enhanced the expression of genes involved in adipogenesis (P<0.01; n = 9), reduced the appearance of histologic markers of inflammation, downregulated both the gene expression and protein expression of the adipose tissue specific inflammation markers CD11c and F4/80 (P<0.001; n = 9) and reduced the gene expression of a battery of chemokine C-C motif ligands (Ccl2, Ccl6, Ccl7, Ccl8, Ccl9) and chemokine C-C motif receptors (Ccr2, Ccr3, Ccr5). We conclude that kale vegetable protects against HFD diet induced dysfunction through mechanisms involving lipid metabolism, endotoxemia and inflammation.
format	article
author	Samnhita Raychaudhuri Si Fan Olivia Kraus Md Shahinozzaman Diana N Obanda
author_facet	Samnhita Raychaudhuri Si Fan Olivia Kraus Md Shahinozzaman Diana N Obanda
author_sort	Samnhita Raychaudhuri
title	Kale supplementation during high fat feeding improves metabolic health in a mouse model of obesity and insulin resistance.
title_short	Kale supplementation during high fat feeding improves metabolic health in a mouse model of obesity and insulin resistance.
title_full	Kale supplementation during high fat feeding improves metabolic health in a mouse model of obesity and insulin resistance.
title_fullStr	Kale supplementation during high fat feeding improves metabolic health in a mouse model of obesity and insulin resistance.
title_full_unstemmed	Kale supplementation during high fat feeding improves metabolic health in a mouse model of obesity and insulin resistance.
title_sort	kale supplementation during high fat feeding improves metabolic health in a mouse model of obesity and insulin resistance.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/9162a6fc7fcd46949402826cd09ee70e
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Kale supplementation during high fat feeding improves metabolic health in a mouse model of obesity and insulin resistance.

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