The Role of Brain-Derived Neurotrophic Factor in Epileptogenesis: an Update

Epilepsy, which is characterized by spontaneous recurrent seizures, is one of the most common and serious chronic neurological diseases in the world. 30% patients failed to control seizures with multiple anti-seizure epileptic drugs, leading to serious outcomes. The pathogenesis of epilepsy is very...

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Autores principales:	Xinyi Wang, Zhe Hu, Kai Zhong
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	epilepsy brain-derived neurotrophic factor tyrosine kinase receptor B treatment target epileptogenesis Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/91635fc921934fc6ad5deed19f37c83d
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spelling	oai:doaj.org-article:91635fc921934fc6ad5deed19f37c83d2021-12-01T06:59:44ZThe Role of Brain-Derived Neurotrophic Factor in Epileptogenesis: an Update1663-981210.3389/fphar.2021.758232https://doaj.org/article/91635fc921934fc6ad5deed19f37c83d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.758232/fullhttps://doaj.org/toc/1663-9812Epilepsy, which is characterized by spontaneous recurrent seizures, is one of the most common and serious chronic neurological diseases in the world. 30% patients failed to control seizures with multiple anti-seizure epileptic drugs, leading to serious outcomes. The pathogenesis of epilepsy is very complex and remains unclear. Brain-derived neurotrophic factor (BDNF), as a member of the neurotrophic factor family, is considered to play an important role in the survival, growth and differentiation of neurons during the development of the central nervous system. Recent years, a series of studies have reported that BDNF can maintain the function of the nervous system and promotes the regeneration of neurons after injury, which is believed to be closely related to epileptogenesis. However, two controversial views (BDNF inhibits or promotes epileptogenesis) still exist. Thus, this mini-review focuses on updating the new evidence of the role of BDNF in epileptogenesis and discussing the possibility of BDNF as an underlying target for the treatment of epilepsy.Xinyi WangZhe HuKai ZhongFrontiers Media S.A.articleepilepsybrain-derived neurotrophic factortyrosine kinase receptor Btreatment targetepileptogenesisTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	epilepsy brain-derived neurotrophic factor tyrosine kinase receptor B treatment target epileptogenesis Therapeutics. Pharmacology RM1-950
spellingShingle	epilepsy brain-derived neurotrophic factor tyrosine kinase receptor B treatment target epileptogenesis Therapeutics. Pharmacology RM1-950 Xinyi Wang Zhe Hu Kai Zhong The Role of Brain-Derived Neurotrophic Factor in Epileptogenesis: an Update
description	Epilepsy, which is characterized by spontaneous recurrent seizures, is one of the most common and serious chronic neurological diseases in the world. 30% patients failed to control seizures with multiple anti-seizure epileptic drugs, leading to serious outcomes. The pathogenesis of epilepsy is very complex and remains unclear. Brain-derived neurotrophic factor (BDNF), as a member of the neurotrophic factor family, is considered to play an important role in the survival, growth and differentiation of neurons during the development of the central nervous system. Recent years, a series of studies have reported that BDNF can maintain the function of the nervous system and promotes the regeneration of neurons after injury, which is believed to be closely related to epileptogenesis. However, two controversial views (BDNF inhibits or promotes epileptogenesis) still exist. Thus, this mini-review focuses on updating the new evidence of the role of BDNF in epileptogenesis and discussing the possibility of BDNF as an underlying target for the treatment of epilepsy.
format	article
author	Xinyi Wang Zhe Hu Kai Zhong
author_facet	Xinyi Wang Zhe Hu Kai Zhong
author_sort	Xinyi Wang
title	The Role of Brain-Derived Neurotrophic Factor in Epileptogenesis: an Update
title_short	The Role of Brain-Derived Neurotrophic Factor in Epileptogenesis: an Update
title_full	The Role of Brain-Derived Neurotrophic Factor in Epileptogenesis: an Update
title_fullStr	The Role of Brain-Derived Neurotrophic Factor in Epileptogenesis: an Update
title_full_unstemmed	The Role of Brain-Derived Neurotrophic Factor in Epileptogenesis: an Update
title_sort	role of brain-derived neurotrophic factor in epileptogenesis: an update
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/91635fc921934fc6ad5deed19f37c83d
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The Role of Brain-Derived Neurotrophic Factor in Epileptogenesis: an Update

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