Vasculogenesis and angiogenesis in diabetes mellitus: novel pathogenetic concepts for treatment of vascular complications
Hyperglycemia along with other metabolic disorders may disrupt the balance of pro- and antiangiogenic regulators, thus leading to a maladaptive formation of new blood vessels in the state of diabetes mellitus (DM). In their turn, aberrant angiogenesis and vasculogenesis are important mechanisms of v...
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Endocrinology Research Centre
2012
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oai:doaj.org-article:91649a654dba469e820910bc5405cdd32021-11-14T09:00:17ZVasculogenesis and angiogenesis in diabetes mellitus: novel pathogenetic concepts for treatment of vascular complications2072-03512072-037810.14341/2072-0351-5533https://doaj.org/article/91649a654dba469e820910bc5405cdd32012-12-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5533https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Hyperglycemia along with other metabolic disorders may disrupt the balance of pro- and antiangiogenic regulators, thus leading to a maladaptive formation of new blood vessels in the state of diabetes mellitus (DM). In their turn, aberrant angiogenesis and vasculogenesis are important mechanisms of vascular complications in DM. Activation of retinal angiogenesis is a cornerstone of proliferative diabetic retinopathy, though in diabetic nephropathy excessive angiogenesis is only seen at early stages. Quite on the contrary, macrovascular complications are characterized by certain inhibition of both angiogenesis and vasculogenesis. Novel therapeutic approaches, based on correction of angiogenesis, have emerged recently. Clinical trials have shown efficacy of angiogenesis inhibitors (the ?anti-VEGF? agents) for management of diabetic macular edema and proliferative retinopathy. Experimental evidence also indicates that this treatment may hinder the progress of diabetic nephropathy. In addition, stimulation of angiogenesis and vasculogenesis with stem cells or growth factors promise an option for treatment of large vessels in DM.Vladimir Iosifovich KonenkovVadim Valer'evich KlimontovEndocrinology Research Centrearticleangiogenesisdiabetic microangiopathymacroangiopathyangiogenesis inhibitorsNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 15, Iss 4, Pp 17-27 (2012) |
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DOAJ |
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EN RU |
| topic |
angiogenesis diabetic microangiopathy macroangiopathy angiogenesis inhibitors Nutritional diseases. Deficiency diseases RC620-627 |
| spellingShingle |
angiogenesis diabetic microangiopathy macroangiopathy angiogenesis inhibitors Nutritional diseases. Deficiency diseases RC620-627 Vladimir Iosifovich Konenkov Vadim Valer'evich Klimontov Vasculogenesis and angiogenesis in diabetes mellitus: novel pathogenetic concepts for treatment of vascular complications |
| description |
Hyperglycemia along with other metabolic disorders may disrupt the balance of pro- and antiangiogenic regulators, thus leading to a maladaptive formation of new blood vessels in the state of diabetes mellitus (DM). In their turn, aberrant angiogenesis and vasculogenesis are important mechanisms of vascular complications in DM. Activation of retinal angiogenesis is a cornerstone of proliferative diabetic retinopathy, though in diabetic nephropathy excessive angiogenesis is only seen at early stages. Quite on the contrary, macrovascular complications are characterized by certain inhibition of both angiogenesis and vasculogenesis. Novel therapeutic approaches, based on correction of angiogenesis, have emerged recently. Clinical trials have shown efficacy of angiogenesis inhibitors (the ?anti-VEGF? agents) for management of diabetic macular edema and proliferative retinopathy. Experimental evidence also indicates that this treatment may hinder the progress of diabetic nephropathy. In addition, stimulation of angiogenesis and vasculogenesis with stem cells or growth factors promise an option for treatment of large vessels in DM. |
| format |
article |
| author |
Vladimir Iosifovich Konenkov Vadim Valer'evich Klimontov |
| author_facet |
Vladimir Iosifovich Konenkov Vadim Valer'evich Klimontov |
| author_sort |
Vladimir Iosifovich Konenkov |
| title |
Vasculogenesis and angiogenesis in diabetes mellitus: novel pathogenetic concepts for treatment of vascular complications |
| title_short |
Vasculogenesis and angiogenesis in diabetes mellitus: novel pathogenetic concepts for treatment of vascular complications |
| title_full |
Vasculogenesis and angiogenesis in diabetes mellitus: novel pathogenetic concepts for treatment of vascular complications |
| title_fullStr |
Vasculogenesis and angiogenesis in diabetes mellitus: novel pathogenetic concepts for treatment of vascular complications |
| title_full_unstemmed |
Vasculogenesis and angiogenesis in diabetes mellitus: novel pathogenetic concepts for treatment of vascular complications |
| title_sort |
vasculogenesis and angiogenesis in diabetes mellitus: novel pathogenetic concepts for treatment of vascular complications |
| publisher |
Endocrinology Research Centre |
| publishDate |
2012 |
| url |
https://doaj.org/article/91649a654dba469e820910bc5405cdd3 |
| work_keys_str_mv |
AT vladimiriosifovichkonenkov vasculogenesisandangiogenesisindiabetesmellitusnovelpathogeneticconceptsfortreatmentofvascularcomplications AT vadimvalerevichklimontov vasculogenesisandangiogenesisindiabetesmellitusnovelpathogeneticconceptsfortreatmentofvascularcomplications |
| _version_ |
1718429593544687616 |