The power of electrified nanoconfinement for energising, controlling and observing long enzyme cascades

Multistep enzymatic reactions (cascades) can be achieved by confining enzymes in synthetic materials, but ways to simultaneously energize, control and observe the reactions in real time are lacking. Here, bidirectional interconversion between aspartate and pyruvate by a five enzyme cascade trapped i...

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Autores principales:	Giorgio Morello, Clare F. Megarity, Fraser A. Armstrong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/91664833a62049bcaba7a424fead66f7
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id	oai:doaj.org-article:91664833a62049bcaba7a424fead66f7
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spelling	oai:doaj.org-article:91664833a62049bcaba7a424fead66f72021-12-02T14:01:14ZThe power of electrified nanoconfinement for energising, controlling and observing long enzyme cascades10.1038/s41467-020-20403-w2041-1723https://doaj.org/article/91664833a62049bcaba7a424fead66f72021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20403-whttps://doaj.org/toc/2041-1723Multistep enzymatic reactions (cascades) can be achieved by confining enzymes in synthetic materials, but ways to simultaneously energize, control and observe the reactions in real time are lacking. Here, bidirectional interconversion between aspartate and pyruvate by a five enzyme cascade trapped in electrode nanopores, addressable by laptop commands, is demonstrated.Giorgio MorelloClare F. MegarityFraser A. ArmstrongNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Giorgio Morello Clare F. Megarity Fraser A. Armstrong The power of electrified nanoconfinement for energising, controlling and observing long enzyme cascades
description	Multistep enzymatic reactions (cascades) can be achieved by confining enzymes in synthetic materials, but ways to simultaneously energize, control and observe the reactions in real time are lacking. Here, bidirectional interconversion between aspartate and pyruvate by a five enzyme cascade trapped in electrode nanopores, addressable by laptop commands, is demonstrated.
format	article
author	Giorgio Morello Clare F. Megarity Fraser A. Armstrong
author_facet	Giorgio Morello Clare F. Megarity Fraser A. Armstrong
author_sort	Giorgio Morello
title	The power of electrified nanoconfinement for energising, controlling and observing long enzyme cascades
title_short	The power of electrified nanoconfinement for energising, controlling and observing long enzyme cascades
title_full	The power of electrified nanoconfinement for energising, controlling and observing long enzyme cascades
title_fullStr	The power of electrified nanoconfinement for energising, controlling and observing long enzyme cascades
title_full_unstemmed	The power of electrified nanoconfinement for energising, controlling and observing long enzyme cascades
title_sort	power of electrified nanoconfinement for energising, controlling and observing long enzyme cascades
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/91664833a62049bcaba7a424fead66f7
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The power of electrified nanoconfinement for energising, controlling and observing long enzyme cascades

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