Different Electrophysiological Responses to Pain-Related Visual Stimuli Between Fibromyalgia and Chronic low Back Pain Women: A Pilot Case-Control Study

Background Fibromyalgia is a chronic pain syndrome which occurs in the absence of an organic damage, whom causes is still unclear. Aims of this pilot study were to investigate the neural correlates of fibromyalgia in response to pain-related visual stimuli and explore the psychological differences a...

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Autores principales:	Carlo Lai, Chiara Ciacchella, Gaia Romana Pellicano, Daniela Altavilla, Daniela Sambucini, Teresa Paolucci, Maria Laura Sorgi, Manuela Di Franco, Raoul Saggini, Paola Aceto
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/9168ff29c9ca4196b7002dfc712a13d0
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spelling	oai:doaj.org-article:9168ff29c9ca4196b7002dfc712a13d02021-12-02T23:03:22ZDifferent Electrophysiological Responses to Pain-Related Visual Stimuli Between Fibromyalgia and Chronic low Back Pain Women: A Pilot Case-Control Study2470-547010.1177/24705470211046881https://doaj.org/article/9168ff29c9ca4196b7002dfc712a13d02021-12-01T00:00:00Zhttps://doi.org/10.1177/24705470211046881https://doaj.org/toc/2470-5470Background Fibromyalgia is a chronic pain syndrome which occurs in the absence of an organic damage, whom causes is still unclear. Aims of this pilot study were to investigate the neural correlates of fibromyalgia in response to pain-related visual stimuli and explore the psychological differences among fibromyalgia, chronic low back pain (CLBP) and healthy conditions. Methods After a clinical assessment, electrophysiological responses to pain-related visual stimuli were recorded using a 256-Hydrocel Geodesic-Sensor-Net. Event-related potentials (ERPs), standardised low-resolution electromagnetic tomography (sLORETA), and psychological (Symptom Checklist-90-Revised) data were analysed for a total sample of 23 women (5 healthy volunteers, 12 fibromyalgia patients, 6 CLBP patients). Results The main finding was that fibromyalgia women reported a different brain response to pain-related visual stimuli on the frontal montage compared to women with CLBP ( p = .028). Moreover, fibromyalgia women showed an increased activity mainly on the hippocampus ( p = .003) and the posterior cingulate cortex ( p ≤ .001) in response to algic stimuli compared to not algic ones. Lastly, these women presented higher scores on the somatization ( p = .002), obsession-compulsion ( p = .045), depression ( p = .043) and positive symptom distress ( p = .023) dimensions compared to the healthy women. Conclusions These preliminary results suggest that although the painful symptoms are similar, the central elaboration of pain could be different between women with fibromyalgia and those with CLBP. Moreover, these findings provide preliminary evidences about the great alert and the central sensitivity to pain-related information regarding fibromyalgia patients.Carlo LaiChiara CiacchellaGaia Romana PellicanoDaniela AltavillaDaniela SambuciniTeresa PaolucciMaria Laura SorgiManuela Di FrancoRaoul SagginiPaola AcetoSAGE PublishingarticlePsychiatryRC435-571ENChronic Stress, Vol 5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psychiatry RC435-571
spellingShingle	Psychiatry RC435-571 Carlo Lai Chiara Ciacchella Gaia Romana Pellicano Daniela Altavilla Daniela Sambucini Teresa Paolucci Maria Laura Sorgi Manuela Di Franco Raoul Saggini Paola Aceto Different Electrophysiological Responses to Pain-Related Visual Stimuli Between Fibromyalgia and Chronic low Back Pain Women: A Pilot Case-Control Study
description	Background Fibromyalgia is a chronic pain syndrome which occurs in the absence of an organic damage, whom causes is still unclear. Aims of this pilot study were to investigate the neural correlates of fibromyalgia in response to pain-related visual stimuli and explore the psychological differences among fibromyalgia, chronic low back pain (CLBP) and healthy conditions. Methods After a clinical assessment, electrophysiological responses to pain-related visual stimuli were recorded using a 256-Hydrocel Geodesic-Sensor-Net. Event-related potentials (ERPs), standardised low-resolution electromagnetic tomography (sLORETA), and psychological (Symptom Checklist-90-Revised) data were analysed for a total sample of 23 women (5 healthy volunteers, 12 fibromyalgia patients, 6 CLBP patients). Results The main finding was that fibromyalgia women reported a different brain response to pain-related visual stimuli on the frontal montage compared to women with CLBP ( p = .028). Moreover, fibromyalgia women showed an increased activity mainly on the hippocampus ( p = .003) and the posterior cingulate cortex ( p ≤ .001) in response to algic stimuli compared to not algic ones. Lastly, these women presented higher scores on the somatization ( p = .002), obsession-compulsion ( p = .045), depression ( p = .043) and positive symptom distress ( p = .023) dimensions compared to the healthy women. Conclusions These preliminary results suggest that although the painful symptoms are similar, the central elaboration of pain could be different between women with fibromyalgia and those with CLBP. Moreover, these findings provide preliminary evidences about the great alert and the central sensitivity to pain-related information regarding fibromyalgia patients.
format	article
author	Carlo Lai Chiara Ciacchella Gaia Romana Pellicano Daniela Altavilla Daniela Sambucini Teresa Paolucci Maria Laura Sorgi Manuela Di Franco Raoul Saggini Paola Aceto
author_facet	Carlo Lai Chiara Ciacchella Gaia Romana Pellicano Daniela Altavilla Daniela Sambucini Teresa Paolucci Maria Laura Sorgi Manuela Di Franco Raoul Saggini Paola Aceto
author_sort	Carlo Lai
title	Different Electrophysiological Responses to Pain-Related Visual Stimuli Between Fibromyalgia and Chronic low Back Pain Women: A Pilot Case-Control Study
title_short	Different Electrophysiological Responses to Pain-Related Visual Stimuli Between Fibromyalgia and Chronic low Back Pain Women: A Pilot Case-Control Study
title_full	Different Electrophysiological Responses to Pain-Related Visual Stimuli Between Fibromyalgia and Chronic low Back Pain Women: A Pilot Case-Control Study
title_fullStr	Different Electrophysiological Responses to Pain-Related Visual Stimuli Between Fibromyalgia and Chronic low Back Pain Women: A Pilot Case-Control Study
title_full_unstemmed	Different Electrophysiological Responses to Pain-Related Visual Stimuli Between Fibromyalgia and Chronic low Back Pain Women: A Pilot Case-Control Study
title_sort	different electrophysiological responses to pain-related visual stimuli between fibromyalgia and chronic low back pain women: a pilot case-control study
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/9168ff29c9ca4196b7002dfc712a13d0
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Different Electrophysiological Responses to Pain-Related Visual Stimuli Between Fibromyalgia and Chronic low Back Pain Women: A Pilot Case-Control Study

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