Influence of Pathogen Type on Neonatal Sepsis Biomarkers

Understanding immunoregulation in newborns can help to determine the pathophysiology of neonatal sepsis and will contribute to improve the diagnosis, prognosis, and treatment and remains an urgent and unmet medical need to understand hyperinflammation or hypoinflammation associated with sepsis in ne...

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Autores principales:	Lyudmila Akhmaltdinova, Svetlana Kolesnichenko, Alyona Lavrinenko, Irina Kadyrova, Olga Avdienko, Lyudmila Panibratec
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Pathology RB1-214
Acceso en línea:	https://doaj.org/article/91726693d2a942559691a93053c01f2a
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spelling	oai:doaj.org-article:91726693d2a942559691a93053c01f2a2021-11-29T00:55:31ZInfluence of Pathogen Type on Neonatal Sepsis Biomarkers2042-009910.1155/2021/1009231https://doaj.org/article/91726693d2a942559691a93053c01f2a2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/1009231https://doaj.org/toc/2042-0099Understanding immunoregulation in newborns can help to determine the pathophysiology of neonatal sepsis and will contribute to improve the diagnosis, prognosis, and treatment and remains an urgent and unmet medical need to understand hyperinflammation or hypoinflammation associated with sepsis in newborns. This study included infants (up to 4 days old). The “sepsis” criteria was a positive blood culture. C-reactive protein demonstrates a strong dependence on the pathogen etiology. Therefore, its diagnostic odds ratio in Gram-positive bacteremia was 2.7 and the sensitivity was 45%, while Gram-negative was 15.0 and 81.8%, respectively. A neutrophil-lymphocyte ratio above 1 and thrombocytopenia below 50∗109 cells/L generally do not depend on the type of pathogen and have a specificity of 95%; however, the sensitivity of these markers is low. nCD64 demonstrated good analytical performance and was equally discriminated in both Gram (+) and Gram (−) cultures. The sensitivity was 87.5–89%, and the specificity was 65%. The HLA-DR and programmed cell death protein study found that activation-deactivation processes in systemic infection is different at points of application depending on the type of pathogen: Gram-positive infections showed various ways of activation of monocytes (by reducing suppressive signals) and lymphocytes (an increase in activation signals), and Gram-negative pathogens were most commonly involved in suppressing monocytic activation. Thus, the difference in the bacteremia model can partially explain the problems with the high variability of immunologic markers in neonatal sepsis.Lyudmila AkhmaltdinovaSvetlana KolesnichenkoAlyona LavrinenkoIrina KadyrovaOlga AvdienkoLyudmila PanibratecHindawi LimitedarticlePathologyRB1-214ENInternational Journal of Inflammation, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pathology RB1-214
spellingShingle	Pathology RB1-214 Lyudmila Akhmaltdinova Svetlana Kolesnichenko Alyona Lavrinenko Irina Kadyrova Olga Avdienko Lyudmila Panibratec Influence of Pathogen Type on Neonatal Sepsis Biomarkers
description	Understanding immunoregulation in newborns can help to determine the pathophysiology of neonatal sepsis and will contribute to improve the diagnosis, prognosis, and treatment and remains an urgent and unmet medical need to understand hyperinflammation or hypoinflammation associated with sepsis in newborns. This study included infants (up to 4 days old). The “sepsis” criteria was a positive blood culture. C-reactive protein demonstrates a strong dependence on the pathogen etiology. Therefore, its diagnostic odds ratio in Gram-positive bacteremia was 2.7 and the sensitivity was 45%, while Gram-negative was 15.0 and 81.8%, respectively. A neutrophil-lymphocyte ratio above 1 and thrombocytopenia below 50∗109 cells/L generally do not depend on the type of pathogen and have a specificity of 95%; however, the sensitivity of these markers is low. nCD64 demonstrated good analytical performance and was equally discriminated in both Gram (+) and Gram (−) cultures. The sensitivity was 87.5–89%, and the specificity was 65%. The HLA-DR and programmed cell death protein study found that activation-deactivation processes in systemic infection is different at points of application depending on the type of pathogen: Gram-positive infections showed various ways of activation of monocytes (by reducing suppressive signals) and lymphocytes (an increase in activation signals), and Gram-negative pathogens were most commonly involved in suppressing monocytic activation. Thus, the difference in the bacteremia model can partially explain the problems with the high variability of immunologic markers in neonatal sepsis.
format	article
author	Lyudmila Akhmaltdinova Svetlana Kolesnichenko Alyona Lavrinenko Irina Kadyrova Olga Avdienko Lyudmila Panibratec
author_facet	Lyudmila Akhmaltdinova Svetlana Kolesnichenko Alyona Lavrinenko Irina Kadyrova Olga Avdienko Lyudmila Panibratec
author_sort	Lyudmila Akhmaltdinova
title	Influence of Pathogen Type on Neonatal Sepsis Biomarkers
title_short	Influence of Pathogen Type on Neonatal Sepsis Biomarkers
title_full	Influence of Pathogen Type on Neonatal Sepsis Biomarkers
title_fullStr	Influence of Pathogen Type on Neonatal Sepsis Biomarkers
title_full_unstemmed	Influence of Pathogen Type on Neonatal Sepsis Biomarkers
title_sort	influence of pathogen type on neonatal sepsis biomarkers
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/91726693d2a942559691a93053c01f2a
work_keys_str_mv	AT lyudmilaakhmaltdinova influenceofpathogentypeonneonatalsepsisbiomarkers AT svetlanakolesnichenko influenceofpathogentypeonneonatalsepsisbiomarkers AT alyonalavrinenko influenceofpathogentypeonneonatalsepsisbiomarkers AT irinakadyrova influenceofpathogentypeonneonatalsepsisbiomarkers AT olgaavdienko influenceofpathogentypeonneonatalsepsisbiomarkers AT lyudmilapanibratec influenceofpathogentypeonneonatalsepsisbiomarkers
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Influence of Pathogen Type on Neonatal Sepsis Biomarkers

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