Current perspectives on CHEK2 mutations in breast cancer

Panagiotis Apostolou, Ioannis Papasotiriou Department of Molecular Medicine, Research Genetic Cancer Centre S.A. (R.G.C.C. S.A.), Florina, Greece Abstract: Checkpoint kinase 2 (CHEK2) is a serine/threonine kinase which is activated upon DNA damage and is implicated in pathways that govern D...

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Autores principales:	Apostolou P, Papasotiriou I
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	CHEK2 breast cancer; Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/917598b101cc43638d92488d7bcd6d41
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id	oai:doaj.org-article:917598b101cc43638d92488d7bcd6d41
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spelling	oai:doaj.org-article:917598b101cc43638d92488d7bcd6d412021-12-02T05:42:53ZCurrent perspectives on CHEK2 mutations in breast cancer1179-1314https://doaj.org/article/917598b101cc43638d92488d7bcd6d412017-05-01T00:00:00Zhttps://www.dovepress.com/current-perspectives-on-chek2-mutations-in-breast-cancer-peer-reviewed-article-BCTThttps://doaj.org/toc/1179-1314Panagiotis Apostolou, Ioannis Papasotiriou Department of Molecular Medicine, Research Genetic Cancer Centre S.A. (R.G.C.C. S.A.), Florina, Greece Abstract: Checkpoint kinase 2 (CHEK2) is a serine/threonine kinase which is activated upon DNA damage and is implicated in pathways that govern DNA repair, cell cycle arrest or apoptosis in response to the initial damage. Loss of kinase function has been correlated with different types of cancer, mainly breast cancer. CHEK2 functionality is affected by different missense or deleterious mutations. CHEK2*1100delC and I157T are most studied in populations all over the world. Although these variants have been identified in patients with breast cancer, their frequency raises doubts about their importance as risk factors. The present article reviews the recent advances in research on CHEK2 mutations, focusing on breast cancer, based on the latest experimental data. Keywords: CHEK2, breast cancerApostolou PPapasotiriou IDove Medical PressarticleCHEK2breast cancer;Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol Volume 9, Pp 331-335 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	CHEK2 breast cancer; Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	CHEK2 breast cancer; Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Apostolou P Papasotiriou I Current perspectives on CHEK2 mutations in breast cancer
description	Panagiotis Apostolou, Ioannis Papasotiriou Department of Molecular Medicine, Research Genetic Cancer Centre S.A. (R.G.C.C. S.A.), Florina, Greece Abstract: Checkpoint kinase 2 (CHEK2) is a serine/threonine kinase which is activated upon DNA damage and is implicated in pathways that govern DNA repair, cell cycle arrest or apoptosis in response to the initial damage. Loss of kinase function has been correlated with different types of cancer, mainly breast cancer. CHEK2 functionality is affected by different missense or deleterious mutations. CHEK2*1100delC and I157T are most studied in populations all over the world. Although these variants have been identified in patients with breast cancer, their frequency raises doubts about their importance as risk factors. The present article reviews the recent advances in research on CHEK2 mutations, focusing on breast cancer, based on the latest experimental data. Keywords: CHEK2, breast cancer
format	article
author	Apostolou P Papasotiriou I
author_facet	Apostolou P Papasotiriou I
author_sort	Apostolou P
title	Current perspectives on CHEK2 mutations in breast cancer
title_short	Current perspectives on CHEK2 mutations in breast cancer
title_full	Current perspectives on CHEK2 mutations in breast cancer
title_fullStr	Current perspectives on CHEK2 mutations in breast cancer
title_full_unstemmed	Current perspectives on CHEK2 mutations in breast cancer
title_sort	current perspectives on chek2 mutations in breast cancer
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/917598b101cc43638d92488d7bcd6d41
work_keys_str_mv	AT apostoloup currentperspectivesonchek2mutationsinbreastcancer AT papasotirioui currentperspectivesonchek2mutationsinbreastcancer
_version_	1718400245220507648

Current perspectives on CHEK2 mutations in breast cancer

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