Bacteroidota and Lachnospiraceae integration into the gut microbiome at key time points in early life are linked to infant neurodevelopment

The early life microbiome plays critical roles in host development, shaping long-term outcomes including brain functioning. It is not known which initial infant colonizers elicit optimal neurodevelopment; thus, this study investigated the association between gut microbiome succession from the first...

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Autores principales:	Kaitlyn Oliphant, Mehneez Ali, Mark D’Souza, Patrick D. Hughes, Dinanath Sulakhe, Annie Z. Wang, Bingqing Xie, Rummanu Yeasin, Michael E. Msall, Bree Andrews, Erika C. Claud
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	human gut microbiome infant microbiome succession infant neurodevelopment dispersal limitation habitat filtering Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/9178fcc31c054e8c804f8e2d73d50fc7
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spelling	oai:doaj.org-article:9178fcc31c054e8c804f8e2d73d50fc72021-12-01T14:40:59ZBacteroidota and Lachnospiraceae integration into the gut microbiome at key time points in early life are linked to infant neurodevelopment1949-09761949-098410.1080/19490976.2021.1997560https://doaj.org/article/9178fcc31c054e8c804f8e2d73d50fc72021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/19490976.2021.1997560https://doaj.org/toc/1949-0976https://doaj.org/toc/1949-0984The early life microbiome plays critical roles in host development, shaping long-term outcomes including brain functioning. It is not known which initial infant colonizers elicit optimal neurodevelopment; thus, this study investigated the association between gut microbiome succession from the first week of life and head circumference growth (HCG), the earliest validated marker for neurodevelopment. Fecal samples were collected weekly from a preterm infant cohort during their neonatal intensive care unit stay and subjected to 16S rRNA gene sequencing for evaluating gut microbiome composition, in conjunction with clinical data and head circumference measurements. Preterm infants with suboptimal HCG trajectories had a depletion in the abundance/prevalence of Bacteroidota and Lachnospiraceae, independent of morbidity and caloric restriction. The severity of gut microbiome depletion matched the timing of significant HCG pattern separation between study groups at 30-week postmenstrual age demonstrating a potential mediating relationship resultant from clinical practices. Consideration of the clinical variables indicated that optimal infant microbiome succession is primarily driven by dispersal limitation (i.e., delivery mode) and secondarily by habitat filtering (i.e., antibiotics and enteral feeding). Bacteroidota and Lachnospiraceae are known core taxa of the adult microbiome, with roles in dietary glycan foraging, beneficial metabolite production and immunity, and our work provides evidence that their integration into the gut microbiome needs to occur early for optimal neurodevelopment.Kaitlyn OliphantMehneez AliMark D’SouzaPatrick D. HughesDinanath SulakheAnnie Z. WangBingqing XieRummanu YeasinMichael E. MsallBree AndrewsErika C. ClaudTaylor & Francis Grouparticlehuman gut microbiomeinfant microbiome successioninfant neurodevelopmentdispersal limitationhabitat filteringDiseases of the digestive system. GastroenterologyRC799-869ENGut Microbes, Vol 13, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	human gut microbiome infant microbiome succession infant neurodevelopment dispersal limitation habitat filtering Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	human gut microbiome infant microbiome succession infant neurodevelopment dispersal limitation habitat filtering Diseases of the digestive system. Gastroenterology RC799-869 Kaitlyn Oliphant Mehneez Ali Mark D’Souza Patrick D. Hughes Dinanath Sulakhe Annie Z. Wang Bingqing Xie Rummanu Yeasin Michael E. Msall Bree Andrews Erika C. Claud Bacteroidota and Lachnospiraceae integration into the gut microbiome at key time points in early life are linked to infant neurodevelopment
description	The early life microbiome plays critical roles in host development, shaping long-term outcomes including brain functioning. It is not known which initial infant colonizers elicit optimal neurodevelopment; thus, this study investigated the association between gut microbiome succession from the first week of life and head circumference growth (HCG), the earliest validated marker for neurodevelopment. Fecal samples were collected weekly from a preterm infant cohort during their neonatal intensive care unit stay and subjected to 16S rRNA gene sequencing for evaluating gut microbiome composition, in conjunction with clinical data and head circumference measurements. Preterm infants with suboptimal HCG trajectories had a depletion in the abundance/prevalence of Bacteroidota and Lachnospiraceae, independent of morbidity and caloric restriction. The severity of gut microbiome depletion matched the timing of significant HCG pattern separation between study groups at 30-week postmenstrual age demonstrating a potential mediating relationship resultant from clinical practices. Consideration of the clinical variables indicated that optimal infant microbiome succession is primarily driven by dispersal limitation (i.e., delivery mode) and secondarily by habitat filtering (i.e., antibiotics and enteral feeding). Bacteroidota and Lachnospiraceae are known core taxa of the adult microbiome, with roles in dietary glycan foraging, beneficial metabolite production and immunity, and our work provides evidence that their integration into the gut microbiome needs to occur early for optimal neurodevelopment.
format	article
author	Kaitlyn Oliphant Mehneez Ali Mark D’Souza Patrick D. Hughes Dinanath Sulakhe Annie Z. Wang Bingqing Xie Rummanu Yeasin Michael E. Msall Bree Andrews Erika C. Claud
author_facet	Kaitlyn Oliphant Mehneez Ali Mark D’Souza Patrick D. Hughes Dinanath Sulakhe Annie Z. Wang Bingqing Xie Rummanu Yeasin Michael E. Msall Bree Andrews Erika C. Claud
author_sort	Kaitlyn Oliphant
title	Bacteroidota and Lachnospiraceae integration into the gut microbiome at key time points in early life are linked to infant neurodevelopment
title_short	Bacteroidota and Lachnospiraceae integration into the gut microbiome at key time points in early life are linked to infant neurodevelopment
title_full	Bacteroidota and Lachnospiraceae integration into the gut microbiome at key time points in early life are linked to infant neurodevelopment
title_fullStr	Bacteroidota and Lachnospiraceae integration into the gut microbiome at key time points in early life are linked to infant neurodevelopment
title_full_unstemmed	Bacteroidota and Lachnospiraceae integration into the gut microbiome at key time points in early life are linked to infant neurodevelopment
title_sort	bacteroidota and lachnospiraceae integration into the gut microbiome at key time points in early life are linked to infant neurodevelopment
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/9178fcc31c054e8c804f8e2d73d50fc7
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Bacteroidota and Lachnospiraceae integration into the gut microbiome at key time points in early life are linked to infant neurodevelopment

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