Comparative evaluation of several parameters of glycemic homeostasis in patients with functional pituitary adenomas

Aim. To investigate glycemic homeostasis in patients with acromegaly and hyperprolactinaemia due to functional pituitary adenoma. Materials and Methods. We enrolled 48 patients with somatotropinoma (Group 1), 19 patients with somatomammotropinoma (Group 2) and 24 patients with prolactinoma (Group...

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Autores principales:	Rostislavovna Mikityuk, Oksana Olegovna Khizhnyak, Tatiana Ninelovna Sulima
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2014
Materias:	pituitary adenoma acromegaly prolactinoma insulin resistance glycemic homeostasis Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/91793b342a6848cea884ba117b7d34c3
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spelling	oai:doaj.org-article:91793b342a6848cea884ba117b7d34c32021-11-14T09:00:18ZComparative evaluation of several parameters of glycemic homeostasis in patients with functional pituitary adenomas2072-03512072-037810.14341/DM2014170-74https://doaj.org/article/91793b342a6848cea884ba117b7d34c32014-03-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/6309https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To investigate glycemic homeostasis in patients with acromegaly and hyperprolactinaemia due to functional pituitary adenoma. Materials and Methods. We enrolled 48 patients with somatotropinoma (Group 1), 19 patients with somatomammotropinoma (Group 2) and 24 patients with prolactinoma (Group 3) with no history of glycemic disorders. Median age was 48.63?9.98 years; median disease duration was 13.1?6.9 years. The comparison group was composed of overweight or obese patients (n=75). We conducted a comparative analysis of glycemic parameters (Glc0, immunoreactive insulin, HOMA2_S%, HOMA2_B% и HOMA2_IR, Ssum and S under isolated segments of the glycemic curve). We also tested their correlation with plasma levels of growth hormone, prolactin and IGF-1. Results. We detected hyperinsulinemia (>20 ?U/mL) in 35.1% of participants from Group 1, 33.3% and 25% from groups 2 and 3, respectively. There was no statistically significant difference between glycemic parameters of the study groups, though patients were mildly insulin resistant (HOMA2_IR 1.88 to 2.38 units) independantly from tumour secretory activity. Groups 1 and 2 were characterized by significantly higher fasting blood glucose levels vs. comparison group (though still within the reference values), and glucose homeostasis was maintained with lower activity of pancreatic ?-cells. Average Ssumanalysis showed lower glucose tolerance in groups 1 and 2 vs. Group 3. Median S values under isolated glycemic curve segments were significantly higher than in comparison group. Plasma levels of growth hormone did not correlate with Ssum and S parameters in groups 1 and 2. There was a linear correlation between Ssum and plasma IGF-1 levels in patients from Group 1 (r=0.45; p=0.006). We also noted that Ssum had a non-linear correlation with plasma prolactin levels in patients from Group 3 (r=0.41; pRostislavovna MikityukOksana Olegovna KhizhnyakTatiana Ninelovna SulimaEndocrinology Research Centrearticlepituitary adenomaacromegalyprolactinomainsulin resistanceglycemic homeostasisNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 17, Iss 1, Pp 70-74 (2014)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	pituitary adenoma acromegaly prolactinoma insulin resistance glycemic homeostasis Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	pituitary adenoma acromegaly prolactinoma insulin resistance glycemic homeostasis Nutritional diseases. Deficiency diseases RC620-627 Rostislavovna Mikityuk Oksana Olegovna Khizhnyak Tatiana Ninelovna Sulima Comparative evaluation of several parameters of glycemic homeostasis in patients with functional pituitary adenomas
description	Aim. To investigate glycemic homeostasis in patients with acromegaly and hyperprolactinaemia due to functional pituitary adenoma. Materials and Methods. We enrolled 48 patients with somatotropinoma (Group 1), 19 patients with somatomammotropinoma (Group 2) and 24 patients with prolactinoma (Group 3) with no history of glycemic disorders. Median age was 48.63?9.98 years; median disease duration was 13.1?6.9 years. The comparison group was composed of overweight or obese patients (n=75). We conducted a comparative analysis of glycemic parameters (Glc0, immunoreactive insulin, HOMA2_S%, HOMA2_B% и HOMA2_IR, Ssum and S under isolated segments of the glycemic curve). We also tested their correlation with plasma levels of growth hormone, prolactin and IGF-1. Results. We detected hyperinsulinemia (>20 ?U/mL) in 35.1% of participants from Group 1, 33.3% and 25% from groups 2 and 3, respectively. There was no statistically significant difference between glycemic parameters of the study groups, though patients were mildly insulin resistant (HOMA2_IR 1.88 to 2.38 units) independantly from tumour secretory activity. Groups 1 and 2 were characterized by significantly higher fasting blood glucose levels vs. comparison group (though still within the reference values), and glucose homeostasis was maintained with lower activity of pancreatic ?-cells. Average Ssumanalysis showed lower glucose tolerance in groups 1 and 2 vs. Group 3. Median S values under isolated glycemic curve segments were significantly higher than in comparison group. Plasma levels of growth hormone did not correlate with Ssum and S parameters in groups 1 and 2. There was a linear correlation between Ssum and plasma IGF-1 levels in patients from Group 1 (r=0.45; p=0.006). We also noted that Ssum had a non-linear correlation with plasma prolactin levels in patients from Group 3 (r=0.41; p
format	article
author	Rostislavovna Mikityuk Oksana Olegovna Khizhnyak Tatiana Ninelovna Sulima
author_facet	Rostislavovna Mikityuk Oksana Olegovna Khizhnyak Tatiana Ninelovna Sulima
author_sort	Rostislavovna Mikityuk
title	Comparative evaluation of several parameters of glycemic homeostasis in patients with functional pituitary adenomas
title_short	Comparative evaluation of several parameters of glycemic homeostasis in patients with functional pituitary adenomas
title_full	Comparative evaluation of several parameters of glycemic homeostasis in patients with functional pituitary adenomas
title_fullStr	Comparative evaluation of several parameters of glycemic homeostasis in patients with functional pituitary adenomas
title_full_unstemmed	Comparative evaluation of several parameters of glycemic homeostasis in patients with functional pituitary adenomas
title_sort	comparative evaluation of several parameters of glycemic homeostasis in patients with functional pituitary adenomas
publisher	Endocrinology Research Centre
publishDate	2014
url	https://doaj.org/article/91793b342a6848cea884ba117b7d34c3
work_keys_str_mv	AT rostislavovnamikityuk comparativeevaluationofseveralparametersofglycemichomeostasisinpatientswithfunctionalpituitaryadenomas AT oksanaolegovnakhizhnyak comparativeevaluationofseveralparametersofglycemichomeostasisinpatientswithfunctionalpituitaryadenomas AT tatiananinelovnasulima comparativeevaluationofseveralparametersofglycemichomeostasisinpatientswithfunctionalpituitaryadenomas
_version_	1718429593771180032

Comparative evaluation of several parameters of glycemic homeostasis in patients with functional pituitary adenomas

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