Association of Trichomonas vaginalis and cytological abnormalities of the cervix in low risk women.

Association of Trichomonas vaginalis and cytological abnormalities of the cervix in low risk women.

<h4>Objective</h4>Is Trichomonas vaginalis (TV) an inducing factor for the development of (pre-)cancerous lesions of the cervix?<h4>Design</h4>Cross sectional study.<h4>Setting</h4>Screening healthy Belgian women with low infection risk.<h4>Sample</h4>...

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Autores principales: Gilbert G G Donders, Christophe E Depuydt, John-Paul Bogers, Annie J Vereecken
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Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/917a6d5942bd47dca8d773911d7355f7
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spelling oai:doaj.org-article:917a6d5942bd47dca8d773911d7355f72021-11-18T08:39:43ZAssociation of Trichomonas vaginalis and cytological abnormalities of the cervix in low risk women.1932-620310.1371/journal.pone.0086266https://doaj.org/article/917a6d5942bd47dca8d773911d7355f72013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24386492/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>Is Trichomonas vaginalis (TV) an inducing factor for the development of (pre-)cancerous lesions of the cervix?<h4>Design</h4>Cross sectional study.<h4>Setting</h4>Screening healthy Belgian women with low infection risk.<h4>Sample</h4>63,251 consecutive liquid based cervical samples.<h4>Methods</h4>Real time quantitative PCR for presence of TV, 18 HPV types and Pap smear analysis of cytologic abnormalities.<h4>Main outcome measures</h4>Association of TV and HPV with cervix dysplasia.<h4>Results</h4>The overall prevalence of TV DNA was 0.37%, of low risk HPV 2%, of high risk HPV 13.2%, and 8.8 % had cytological abnormalities. Both LR-HPV and HR-HPV were significantly associated with all cytological abnormalities. Presence of TV was associated with LR- and HR-HPV, ASC-US and HSIL, but not with other abnormalities. All women with TV and HSIL also had HR-HPV, while the latter was present in only 59% of women with TV and ASC-US. Amongst HPV negative women, TV was found in 1.3% of women with ASC-US, but only in 0.03% of women with normal cytology (OR 4.2, CL95% 2.1-8.6). In HR-HPV positive women, presence of TV increased the likelihood of cytological abnormalities somewhat (P=0.05), mainly due to an increase in ASC-US and LSIL, but not HSIL.<h4>Conclusions</h4>We conclude that TV infection is associated with both LR and HR-HPV infection of the cervix, as well as with ASC-US and HSIL. TV is a concomitant STI, but is not thought to be a co-factor in the causation of HSIL and cervical cancer. However, TV may cause false positive diagnoses of ASC-US.Gilbert G G DondersChristophe E DepuydtJohn-Paul BogersAnnie J VereeckenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e86266 (2013)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Gilbert G G Donders
Christophe E Depuydt
John-Paul Bogers
Annie J Vereecken
Association of Trichomonas vaginalis and cytological abnormalities of the cervix in low risk women.
description <h4>Objective</h4>Is Trichomonas vaginalis (TV) an inducing factor for the development of (pre-)cancerous lesions of the cervix?<h4>Design</h4>Cross sectional study.<h4>Setting</h4>Screening healthy Belgian women with low infection risk.<h4>Sample</h4>63,251 consecutive liquid based cervical samples.<h4>Methods</h4>Real time quantitative PCR for presence of TV, 18 HPV types and Pap smear analysis of cytologic abnormalities.<h4>Main outcome measures</h4>Association of TV and HPV with cervix dysplasia.<h4>Results</h4>The overall prevalence of TV DNA was 0.37%, of low risk HPV 2%, of high risk HPV 13.2%, and 8.8 % had cytological abnormalities. Both LR-HPV and HR-HPV were significantly associated with all cytological abnormalities. Presence of TV was associated with LR- and HR-HPV, ASC-US and HSIL, but not with other abnormalities. All women with TV and HSIL also had HR-HPV, while the latter was present in only 59% of women with TV and ASC-US. Amongst HPV negative women, TV was found in 1.3% of women with ASC-US, but only in 0.03% of women with normal cytology (OR 4.2, CL95% 2.1-8.6). In HR-HPV positive women, presence of TV increased the likelihood of cytological abnormalities somewhat (P=0.05), mainly due to an increase in ASC-US and LSIL, but not HSIL.<h4>Conclusions</h4>We conclude that TV infection is associated with both LR and HR-HPV infection of the cervix, as well as with ASC-US and HSIL. TV is a concomitant STI, but is not thought to be a co-factor in the causation of HSIL and cervical cancer. However, TV may cause false positive diagnoses of ASC-US.
format article
author Gilbert G G Donders
Christophe E Depuydt
John-Paul Bogers
Annie J Vereecken
author_facet Gilbert G G Donders
Christophe E Depuydt
John-Paul Bogers
Annie J Vereecken
author_sort Gilbert G G Donders
title Association of Trichomonas vaginalis and cytological abnormalities of the cervix in low risk women.
title_short Association of Trichomonas vaginalis and cytological abnormalities of the cervix in low risk women.
title_full Association of Trichomonas vaginalis and cytological abnormalities of the cervix in low risk women.
title_fullStr Association of Trichomonas vaginalis and cytological abnormalities of the cervix in low risk women.
title_full_unstemmed Association of Trichomonas vaginalis and cytological abnormalities of the cervix in low risk women.
title_sort association of trichomonas vaginalis and cytological abnormalities of the cervix in low risk women.
publisher Public Library of Science (PLoS)
publishDate 2013
url https://doaj.org/article/917a6d5942bd47dca8d773911d7355f7
work_keys_str_mv AT gilbertggdonders associationoftrichomonasvaginalisandcytologicalabnormalitiesofthecervixinlowriskwomen
AT christopheedepuydt associationoftrichomonasvaginalisandcytologicalabnormalitiesofthecervixinlowriskwomen
AT johnpaulbogers associationoftrichomonasvaginalisandcytologicalabnormalitiesofthecervixinlowriskwomen
AT anniejvereecken associationoftrichomonasvaginalisandcytologicalabnormalitiesofthecervixinlowriskwomen
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