Mechanical cell competition kills cells via induction of lethal p53 levels

Cell competition is a quality control mechanism to eliminate unfit cells. Here the authors show that physical compaction of less fit cells surrounded by healthy neighbours leads to increased expression of tumour suppressor p53 in the compacted cells, causing cell death.

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Autores principales:	Laura Wagstaff, Maja Goschorska, Kasia Kozyrska, Guillaume Duclos, Iwo Kucinski, Anatole Chessel, Lea Hampton-O’Neil, Charles R. Bradshaw, George E. Allen, Emma L. Rawlins, Pascal Silberzan, Rafael E. Carazo Salas, Eugenia Piddini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/917bfec21e0c49399454b3445695a286
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spelling	oai:doaj.org-article:917bfec21e0c49399454b3445695a2862021-12-02T17:32:50ZMechanical cell competition kills cells via induction of lethal p53 levels10.1038/ncomms113732041-1723https://doaj.org/article/917bfec21e0c49399454b3445695a2862016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11373https://doaj.org/toc/2041-1723Cell competition is a quality control mechanism to eliminate unfit cells. Here the authors show that physical compaction of less fit cells surrounded by healthy neighbours leads to increased expression of tumour suppressor p53 in the compacted cells, causing cell death.Laura WagstaffMaja GoschorskaKasia KozyrskaGuillaume DuclosIwo KucinskiAnatole ChesselLea Hampton-O’NeilCharles R. BradshawGeorge E. AllenEmma L. RawlinsPascal SilberzanRafael E. Carazo SalasEugenia PiddiniNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Laura Wagstaff Maja Goschorska Kasia Kozyrska Guillaume Duclos Iwo Kucinski Anatole Chessel Lea Hampton-O’Neil Charles R. Bradshaw George E. Allen Emma L. Rawlins Pascal Silberzan Rafael E. Carazo Salas Eugenia Piddini Mechanical cell competition kills cells via induction of lethal p53 levels
description	Cell competition is a quality control mechanism to eliminate unfit cells. Here the authors show that physical compaction of less fit cells surrounded by healthy neighbours leads to increased expression of tumour suppressor p53 in the compacted cells, causing cell death.
format	article
author	Laura Wagstaff Maja Goschorska Kasia Kozyrska Guillaume Duclos Iwo Kucinski Anatole Chessel Lea Hampton-O’Neil Charles R. Bradshaw George E. Allen Emma L. Rawlins Pascal Silberzan Rafael E. Carazo Salas Eugenia Piddini
author_facet	Laura Wagstaff Maja Goschorska Kasia Kozyrska Guillaume Duclos Iwo Kucinski Anatole Chessel Lea Hampton-O’Neil Charles R. Bradshaw George E. Allen Emma L. Rawlins Pascal Silberzan Rafael E. Carazo Salas Eugenia Piddini
author_sort	Laura Wagstaff
title	Mechanical cell competition kills cells via induction of lethal p53 levels
title_short	Mechanical cell competition kills cells via induction of lethal p53 levels
title_full	Mechanical cell competition kills cells via induction of lethal p53 levels
title_fullStr	Mechanical cell competition kills cells via induction of lethal p53 levels
title_full_unstemmed	Mechanical cell competition kills cells via induction of lethal p53 levels
title_sort	mechanical cell competition kills cells via induction of lethal p53 levels
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/917bfec21e0c49399454b3445695a286
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Mechanical cell competition kills cells via induction of lethal p53 levels

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