Conversion of anilines to chiral benzylic amines via formal one-carbon insertion into aromatic C–N bonds

Atom insertion into aromatic carbon-nitrogen (C-N) bonds is useful for the synthesis of nitrogen-containing molecules, but challenging due to the inert nature of these bonds. Here, the authors report one-carbon insertion into aromatic C-N bonds to directly convert anilines to chiral benzylic amines.

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Autores principales:	Lei Li, Min Yang, Qiuqin He, Renhua Fan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/917c54f7881d431788d492095569abd1
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spelling	oai:doaj.org-article:917c54f7881d431788d492095569abd12021-12-02T18:48:04ZConversion of anilines to chiral benzylic amines via formal one-carbon insertion into aromatic C–N bonds10.1038/s41467-020-18593-42041-1723https://doaj.org/article/917c54f7881d431788d492095569abd12020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18593-4https://doaj.org/toc/2041-1723Atom insertion into aromatic carbon-nitrogen (C-N) bonds is useful for the synthesis of nitrogen-containing molecules, but challenging due to the inert nature of these bonds. Here, the authors report one-carbon insertion into aromatic C-N bonds to directly convert anilines to chiral benzylic amines.Lei LiMin YangQiuqin HeRenhua FanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lei Li Min Yang Qiuqin He Renhua Fan Conversion of anilines to chiral benzylic amines via formal one-carbon insertion into aromatic C–N bonds
description	Atom insertion into aromatic carbon-nitrogen (C-N) bonds is useful for the synthesis of nitrogen-containing molecules, but challenging due to the inert nature of these bonds. Here, the authors report one-carbon insertion into aromatic C-N bonds to directly convert anilines to chiral benzylic amines.
format	article
author	Lei Li Min Yang Qiuqin He Renhua Fan
author_facet	Lei Li Min Yang Qiuqin He Renhua Fan
author_sort	Lei Li
title	Conversion of anilines to chiral benzylic amines via formal one-carbon insertion into aromatic C–N bonds
title_short	Conversion of anilines to chiral benzylic amines via formal one-carbon insertion into aromatic C–N bonds
title_full	Conversion of anilines to chiral benzylic amines via formal one-carbon insertion into aromatic C–N bonds
title_fullStr	Conversion of anilines to chiral benzylic amines via formal one-carbon insertion into aromatic C–N bonds
title_full_unstemmed	Conversion of anilines to chiral benzylic amines via formal one-carbon insertion into aromatic C–N bonds
title_sort	conversion of anilines to chiral benzylic amines via formal one-carbon insertion into aromatic c–n bonds
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/917c54f7881d431788d492095569abd1
work_keys_str_mv	AT leili conversionofanilinestochiralbenzylicaminesviaformalonecarboninsertionintoaromaticcnbonds AT minyang conversionofanilinestochiralbenzylicaminesviaformalonecarboninsertionintoaromaticcnbonds AT qiuqinhe conversionofanilinestochiralbenzylicaminesviaformalonecarboninsertionintoaromaticcnbonds AT renhuafan conversionofanilinestochiralbenzylicaminesviaformalonecarboninsertionintoaromaticcnbonds
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Conversion of anilines to chiral benzylic amines via formal one-carbon insertion into aromatic C–N bonds

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