Aging Does Not Exacerbate Muscle Loss During Denervation and Lends Unique Muscle-Specific Atrophy Resistance With Akt Activation

Sarcopenia, or age-related skeletal muscle atrophy and weakness, imposes significant clinical and economic burdens on affected patients and societies. Neurological degeneration, such as motoneuron death, has been recognized as a key contributor to sarcopenia. However, little is known about how aged/...

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Autores principales:	Jae-Sung You, Jie Chen
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	aging muscle denervation protein synthesis rRNA Akt Physiology QP1-981
Acceso en línea:	https://doaj.org/article/917d3625024e40249a9a54549afc718b
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spelling	oai:doaj.org-article:917d3625024e40249a9a54549afc718b2021-12-01T18:17:39ZAging Does Not Exacerbate Muscle Loss During Denervation and Lends Unique Muscle-Specific Atrophy Resistance With Akt Activation1664-042X10.3389/fphys.2021.779547https://doaj.org/article/917d3625024e40249a9a54549afc718b2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.779547/fullhttps://doaj.org/toc/1664-042XSarcopenia, or age-related skeletal muscle atrophy and weakness, imposes significant clinical and economic burdens on affected patients and societies. Neurological degeneration, such as motoneuron death, has been recognized as a key contributor to sarcopenia. However, little is known about how aged/sarcopenic muscle adapts to this denervation stress. Here, we show that mice at 27months of age exhibit clear signs of sarcopenia but no accelerated denervation-induced muscle atrophy when compared to 8-month-old mice. Surprisingly, aging lends unique atrophy resistance to tibialis anteria muscle, accompanied by an increase in the cascade of mammalian target of rapamycin complex 1 (mTORC1)-independent anabolic events involving Akt signaling, rRNA biogenesis, and protein synthesis during denervation. These results expand our understanding of age-dependent stress responses and may help develop better countermeasures to sarcopenia.Jae-Sung YouJie ChenFrontiers Media S.A.articleagingmuscledenervationprotein synthesisrRNAAktPhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	aging muscle denervation protein synthesis rRNA Akt Physiology QP1-981
spellingShingle	aging muscle denervation protein synthesis rRNA Akt Physiology QP1-981 Jae-Sung You Jie Chen Aging Does Not Exacerbate Muscle Loss During Denervation and Lends Unique Muscle-Specific Atrophy Resistance With Akt Activation
description	Sarcopenia, or age-related skeletal muscle atrophy and weakness, imposes significant clinical and economic burdens on affected patients and societies. Neurological degeneration, such as motoneuron death, has been recognized as a key contributor to sarcopenia. However, little is known about how aged/sarcopenic muscle adapts to this denervation stress. Here, we show that mice at 27months of age exhibit clear signs of sarcopenia but no accelerated denervation-induced muscle atrophy when compared to 8-month-old mice. Surprisingly, aging lends unique atrophy resistance to tibialis anteria muscle, accompanied by an increase in the cascade of mammalian target of rapamycin complex 1 (mTORC1)-independent anabolic events involving Akt signaling, rRNA biogenesis, and protein synthesis during denervation. These results expand our understanding of age-dependent stress responses and may help develop better countermeasures to sarcopenia.
format	article
author	Jae-Sung You Jie Chen
author_facet	Jae-Sung You Jie Chen
author_sort	Jae-Sung You
title	Aging Does Not Exacerbate Muscle Loss During Denervation and Lends Unique Muscle-Specific Atrophy Resistance With Akt Activation
title_short	Aging Does Not Exacerbate Muscle Loss During Denervation and Lends Unique Muscle-Specific Atrophy Resistance With Akt Activation
title_full	Aging Does Not Exacerbate Muscle Loss During Denervation and Lends Unique Muscle-Specific Atrophy Resistance With Akt Activation
title_fullStr	Aging Does Not Exacerbate Muscle Loss During Denervation and Lends Unique Muscle-Specific Atrophy Resistance With Akt Activation
title_full_unstemmed	Aging Does Not Exacerbate Muscle Loss During Denervation and Lends Unique Muscle-Specific Atrophy Resistance With Akt Activation
title_sort	aging does not exacerbate muscle loss during denervation and lends unique muscle-specific atrophy resistance with akt activation
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/917d3625024e40249a9a54549afc718b
work_keys_str_mv	AT jaesungyou agingdoesnotexacerbatemusclelossduringdenervationandlendsuniquemusclespecificatrophyresistancewithaktactivation AT jiechen agingdoesnotexacerbatemusclelossduringdenervationandlendsuniquemusclespecificatrophyresistancewithaktactivation
_version_	1718404705984446464

Aging Does Not Exacerbate Muscle Loss During Denervation and Lends Unique Muscle-Specific Atrophy Resistance With Akt Activation

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