Spike residue 403 affects binding of coronavirus spikes to human ACE2
The bat sarbecovirus RaTG13 is a close relative of SARS-CoV-2, but its spike protein doesn’t efficiently bind human ACE2. Here, the authors show that exchange of spike residue 403 between RaTG13 and SARS-CoV-2 spike proteins affects binding to human ACE2 and entry of pseudotyped viruses.
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Nature Portfolio
2021
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oai:doaj.org-article:91810263eb144d8ba565afe0bc95450d2021-11-28T12:31:55ZSpike residue 403 affects binding of coronavirus spikes to human ACE210.1038/s41467-021-27180-02041-1723https://doaj.org/article/91810263eb144d8ba565afe0bc95450d2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27180-0https://doaj.org/toc/2041-1723The bat sarbecovirus RaTG13 is a close relative of SARS-CoV-2, but its spike protein doesn’t efficiently bind human ACE2. Here, the authors show that exchange of spike residue 403 between RaTG13 and SARS-CoV-2 spike proteins affects binding to human ACE2 and entry of pseudotyped viruses.Fabian ZechDaniel SchniertshauerChristoph JungAlexandra HerrmannArne CordsmeierQinya XieRayhane NchiouaCaterina Prelli BozzoMeta VolcicLennart KoepkeJanis A. MüllerJana KrügerSandra HellerSteffen StengerMarkus HoffmannStefan PöhlmannAlexander KlegerTimo JacobKarl-Klaus ConzelmannArmin EnsserKonstantin M. J. SparrerFrank KirchhoffNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Fabian Zech Daniel Schniertshauer Christoph Jung Alexandra Herrmann Arne Cordsmeier Qinya Xie Rayhane Nchioua Caterina Prelli Bozzo Meta Volcic Lennart Koepke Janis A. Müller Jana Krüger Sandra Heller Steffen Stenger Markus Hoffmann Stefan Pöhlmann Alexander Kleger Timo Jacob Karl-Klaus Conzelmann Armin Ensser Konstantin M. J. Sparrer Frank Kirchhoff Spike residue 403 affects binding of coronavirus spikes to human ACE2 |
| description |
The bat sarbecovirus RaTG13 is a close relative of SARS-CoV-2, but its spike protein doesn’t efficiently bind human ACE2. Here, the authors show that exchange of spike residue 403 between RaTG13 and SARS-CoV-2 spike proteins affects binding to human ACE2 and entry of pseudotyped viruses. |
| format |
article |
| author |
Fabian Zech Daniel Schniertshauer Christoph Jung Alexandra Herrmann Arne Cordsmeier Qinya Xie Rayhane Nchioua Caterina Prelli Bozzo Meta Volcic Lennart Koepke Janis A. Müller Jana Krüger Sandra Heller Steffen Stenger Markus Hoffmann Stefan Pöhlmann Alexander Kleger Timo Jacob Karl-Klaus Conzelmann Armin Ensser Konstantin M. J. Sparrer Frank Kirchhoff |
| author_facet |
Fabian Zech Daniel Schniertshauer Christoph Jung Alexandra Herrmann Arne Cordsmeier Qinya Xie Rayhane Nchioua Caterina Prelli Bozzo Meta Volcic Lennart Koepke Janis A. Müller Jana Krüger Sandra Heller Steffen Stenger Markus Hoffmann Stefan Pöhlmann Alexander Kleger Timo Jacob Karl-Klaus Conzelmann Armin Ensser Konstantin M. J. Sparrer Frank Kirchhoff |
| author_sort |
Fabian Zech |
| title |
Spike residue 403 affects binding of coronavirus spikes to human ACE2 |
| title_short |
Spike residue 403 affects binding of coronavirus spikes to human ACE2 |
| title_full |
Spike residue 403 affects binding of coronavirus spikes to human ACE2 |
| title_fullStr |
Spike residue 403 affects binding of coronavirus spikes to human ACE2 |
| title_full_unstemmed |
Spike residue 403 affects binding of coronavirus spikes to human ACE2 |
| title_sort |
spike residue 403 affects binding of coronavirus spikes to human ace2 |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/91810263eb144d8ba565afe0bc95450d |
| work_keys_str_mv |
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