Cytokine release syndrome and tumor lysis syndrome in a multiple myeloma patient treated with palliative radiotherapy: A case report and review of the literature

We present the case of a 53-year-old woman treated with analgesic radiotherapy for a multiple myeloma bone lesion of the forearm. After a first fraction of 5 Gray (Gy), she presented with an acute respiratory syndrome with fever a few hours after the treatment. The same symptoms occurred after the s...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Axel Cailleteau, Cyrille Touzeau, Bastien Jamet, Valentine Guimas, Emmanuel Jouglar, Stéphane Supiot
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Cytokine release syndrome Tumor lysis syndrome Multiple myeloma Radiotherapy Leukemia Hematology Medical physics. Medical radiology. Nuclear medicine R895-920 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/9181bb8f3b704cc8a85f6ec6356f4bf8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9181bb8f3b704cc8a85f6ec6356f4bf8
record_format	dspace
spelling	oai:doaj.org-article:9181bb8f3b704cc8a85f6ec6356f4bf82021-11-16T04:10:52ZCytokine release syndrome and tumor lysis syndrome in a multiple myeloma patient treated with palliative radiotherapy: A case report and review of the literature2405-630810.1016/j.ctro.2021.11.004https://doaj.org/article/9181bb8f3b704cc8a85f6ec6356f4bf82022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2405630821000951https://doaj.org/toc/2405-6308We present the case of a 53-year-old woman treated with analgesic radiotherapy for a multiple myeloma bone lesion of the forearm. After a first fraction of 5 Gray (Gy), she presented with an acute respiratory syndrome with fever a few hours after the treatment. The same symptoms occurred after the second fraction 3 days later. The patient recovered quickly thanks to intravenous hydration and suspension of the radiotherapy. Biological tests revealed a tumor lysis syndrome. We concluded that the clinical symptoms could be defined as cytokine release syndrome. This is the second time in the literature that cytokine release syndrome has been described following radiotherapy. First, we synthesize TLS and radiotherapy to determine how radiotherapy could be a trigger associated with other well-known factors. Furthermore, we discuss radiotherapy and cytokine release syndrome. Summary: We present the case of a woman treated with analgesic radiotherapy for a multiple myeloma bone lesion. Following the first and the second treatment fraction, the patient presented with an acute respiratory syndrome with fever and biological tests revealed a tumor lysis syndrome. We concluded that the clinical symptoms could be defined as cytokine release syndrome. Furthermore, we discuss how radiotherapy could be a trigger of cytokine release syndrome and tumor lysis syndrome in association with chemotherapy drugs.Axel CailleteauCyrille TouzeauBastien JametValentine GuimasEmmanuel JouglarStéphane SupiotElsevierarticleCytokine release syndromeTumor lysis syndromeMultiple myelomaRadiotherapyLeukemiaHematologyMedical physics. Medical radiology. Nuclear medicineR895-920Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENClinical and Translational Radiation Oncology, Vol 32, Iss , Pp 24-28 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytokine release syndrome Tumor lysis syndrome Multiple myeloma Radiotherapy Leukemia Hematology Medical physics. Medical radiology. Nuclear medicine R895-920 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Cytokine release syndrome Tumor lysis syndrome Multiple myeloma Radiotherapy Leukemia Hematology Medical physics. Medical radiology. Nuclear medicine R895-920 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Axel Cailleteau Cyrille Touzeau Bastien Jamet Valentine Guimas Emmanuel Jouglar Stéphane Supiot Cytokine release syndrome and tumor lysis syndrome in a multiple myeloma patient treated with palliative radiotherapy: A case report and review of the literature
description	We present the case of a 53-year-old woman treated with analgesic radiotherapy for a multiple myeloma bone lesion of the forearm. After a first fraction of 5 Gray (Gy), she presented with an acute respiratory syndrome with fever a few hours after the treatment. The same symptoms occurred after the second fraction 3 days later. The patient recovered quickly thanks to intravenous hydration and suspension of the radiotherapy. Biological tests revealed a tumor lysis syndrome. We concluded that the clinical symptoms could be defined as cytokine release syndrome. This is the second time in the literature that cytokine release syndrome has been described following radiotherapy. First, we synthesize TLS and radiotherapy to determine how radiotherapy could be a trigger associated with other well-known factors. Furthermore, we discuss radiotherapy and cytokine release syndrome. Summary: We present the case of a woman treated with analgesic radiotherapy for a multiple myeloma bone lesion. Following the first and the second treatment fraction, the patient presented with an acute respiratory syndrome with fever and biological tests revealed a tumor lysis syndrome. We concluded that the clinical symptoms could be defined as cytokine release syndrome. Furthermore, we discuss how radiotherapy could be a trigger of cytokine release syndrome and tumor lysis syndrome in association with chemotherapy drugs.
format	article
author	Axel Cailleteau Cyrille Touzeau Bastien Jamet Valentine Guimas Emmanuel Jouglar Stéphane Supiot
author_facet	Axel Cailleteau Cyrille Touzeau Bastien Jamet Valentine Guimas Emmanuel Jouglar Stéphane Supiot
author_sort	Axel Cailleteau
title	Cytokine release syndrome and tumor lysis syndrome in a multiple myeloma patient treated with palliative radiotherapy: A case report and review of the literature
title_short	Cytokine release syndrome and tumor lysis syndrome in a multiple myeloma patient treated with palliative radiotherapy: A case report and review of the literature
title_full	Cytokine release syndrome and tumor lysis syndrome in a multiple myeloma patient treated with palliative radiotherapy: A case report and review of the literature
title_fullStr	Cytokine release syndrome and tumor lysis syndrome in a multiple myeloma patient treated with palliative radiotherapy: A case report and review of the literature
title_full_unstemmed	Cytokine release syndrome and tumor lysis syndrome in a multiple myeloma patient treated with palliative radiotherapy: A case report and review of the literature
title_sort	cytokine release syndrome and tumor lysis syndrome in a multiple myeloma patient treated with palliative radiotherapy: a case report and review of the literature
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/9181bb8f3b704cc8a85f6ec6356f4bf8
work_keys_str_mv	AT axelcailleteau cytokinereleasesyndromeandtumorlysissyndromeinamultiplemyelomapatienttreatedwithpalliativeradiotherapyacasereportandreviewoftheliterature AT cyrilletouzeau cytokinereleasesyndromeandtumorlysissyndromeinamultiplemyelomapatienttreatedwithpalliativeradiotherapyacasereportandreviewoftheliterature AT bastienjamet cytokinereleasesyndromeandtumorlysissyndromeinamultiplemyelomapatienttreatedwithpalliativeradiotherapyacasereportandreviewoftheliterature AT valentineguimas cytokinereleasesyndromeandtumorlysissyndromeinamultiplemyelomapatienttreatedwithpalliativeradiotherapyacasereportandreviewoftheliterature AT emmanueljouglar cytokinereleasesyndromeandtumorlysissyndromeinamultiplemyelomapatienttreatedwithpalliativeradiotherapyacasereportandreviewoftheliterature AT stephanesupiot cytokinereleasesyndromeandtumorlysissyndromeinamultiplemyelomapatienttreatedwithpalliativeradiotherapyacasereportandreviewoftheliterature
_version_	1718426738552209408

Cytokine release syndrome and tumor lysis syndrome in a multiple myeloma patient treated with palliative radiotherapy: A case report and review of the literature

Ejemplares similares