The metabolites NADP+ and NADPH are the targets of the circadian protein Nocturnin (Curled)

Nocturnin is a rhythmically expressed protein that regulates metabolism under the control of circadian clock proposed to function through the deadenylation of metabolic enzyme mRNAs. Here the authors show that Nocturnin and its fly homolog Curled catalyze the removal of 2′-phosphate from NADP+ and N...

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Autores principales:	Michael A. Estrella, Jin Du, Li Chen, Sneha Rath, Eliza Prangley, Alisha Chitrakar, Tsutomu Aoki, Paul Schedl, Joshua Rabinowitz, Alexei Korennykh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/91822378ee9c4553912dbca3ceb0472b
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spelling	oai:doaj.org-article:91822378ee9c4553912dbca3ceb0472b2021-12-02T14:35:51ZThe metabolites NADP+ and NADPH are the targets of the circadian protein Nocturnin (Curled)10.1038/s41467-019-10125-z2041-1723https://doaj.org/article/91822378ee9c4553912dbca3ceb0472b2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10125-zhttps://doaj.org/toc/2041-1723Nocturnin is a rhythmically expressed protein that regulates metabolism under the control of circadian clock proposed to function through the deadenylation of metabolic enzyme mRNAs. Here the authors show that Nocturnin and its fly homolog Curled catalyze the removal of 2′-phosphate from NADP+ and NADPH, providing a direct link to metabolic regulation.Michael A. EstrellaJin DuLi ChenSneha RathEliza PrangleyAlisha ChitrakarTsutomu AokiPaul SchedlJoshua RabinowitzAlexei KorennykhNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael A. Estrella Jin Du Li Chen Sneha Rath Eliza Prangley Alisha Chitrakar Tsutomu Aoki Paul Schedl Joshua Rabinowitz Alexei Korennykh The metabolites NADP+ and NADPH are the targets of the circadian protein Nocturnin (Curled)
description	Nocturnin is a rhythmically expressed protein that regulates metabolism under the control of circadian clock proposed to function through the deadenylation of metabolic enzyme mRNAs. Here the authors show that Nocturnin and its fly homolog Curled catalyze the removal of 2′-phosphate from NADP+ and NADPH, providing a direct link to metabolic regulation.
format	article
author	Michael A. Estrella Jin Du Li Chen Sneha Rath Eliza Prangley Alisha Chitrakar Tsutomu Aoki Paul Schedl Joshua Rabinowitz Alexei Korennykh
author_facet	Michael A. Estrella Jin Du Li Chen Sneha Rath Eliza Prangley Alisha Chitrakar Tsutomu Aoki Paul Schedl Joshua Rabinowitz Alexei Korennykh
author_sort	Michael A. Estrella
title	The metabolites NADP+ and NADPH are the targets of the circadian protein Nocturnin (Curled)
title_short	The metabolites NADP+ and NADPH are the targets of the circadian protein Nocturnin (Curled)
title_full	The metabolites NADP+ and NADPH are the targets of the circadian protein Nocturnin (Curled)
title_fullStr	The metabolites NADP+ and NADPH are the targets of the circadian protein Nocturnin (Curled)
title_full_unstemmed	The metabolites NADP+ and NADPH are the targets of the circadian protein Nocturnin (Curled)
title_sort	metabolites nadp+ and nadph are the targets of the circadian protein nocturnin (curled)
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/91822378ee9c4553912dbca3ceb0472b
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The metabolites NADP+ and NADPH are the targets of the circadian protein Nocturnin (Curled)

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