Functional cis-regulatory modules encoded by mouse-specific endogenous retrovirus

The gene-battery model posits transposable elements (TEs) may becis-regulatory elements to control gene expression. Here, mouse-specific TEs are shown as binding sites for multiple collaborating transcription factors in embryonic stem cells, and act as cis-regulatory modules in synergistic fashion.

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Detalles Bibliográficos
Autores principales: Vasavi Sundaram, Mayank N. K. Choudhary, Erica Pehrsson, Xiaoyun Xing, Christopher Fiore, Manishi Pandey, Brett Maricque, Methma Udawatta, Duc Ngo, Yujie Chen, Asia Paguntalan, Tammy Ray, Ava Hughes, Barak A. Cohen, Ting Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/9182e1481f7b4fb78384a75c96e24065
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Sumario:The gene-battery model posits transposable elements (TEs) may becis-regulatory elements to control gene expression. Here, mouse-specific TEs are shown as binding sites for multiple collaborating transcription factors in embryonic stem cells, and act as cis-regulatory modules in synergistic fashion.