Mechanically interlocked functionalization of monoclonal antibodies

Meditope-Fab is a peptide-antibody complex potentially useful for drug delivery and diagnostic, but a short half-life prevents its use in vivo. Here the authors engineer the complex to improve its stability, create functionalized antibodies by click chemistry and use them for in vivo tumor imaging.

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Detalles Bibliográficos
Autores principales:	Krzysztof P. Bzymek, James W. Puckett, Cindy Zer, Jun Xie, Yuelong Ma, Jeremy D. King, Leah H. Goodstein, Kendra N. Avery, David Colcher, Gagandeep Singh, David A. Horne, John C. Williams
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9183f2a427c44a76a8fa504cd3b997a4
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spelling	oai:doaj.org-article:9183f2a427c44a76a8fa504cd3b997a42021-12-02T16:49:34ZMechanically interlocked functionalization of monoclonal antibodies10.1038/s41467-018-03976-52041-1723https://doaj.org/article/9183f2a427c44a76a8fa504cd3b997a42018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03976-5https://doaj.org/toc/2041-1723Meditope-Fab is a peptide-antibody complex potentially useful for drug delivery and diagnostic, but a short half-life prevents its use in vivo. Here the authors engineer the complex to improve its stability, create functionalized antibodies by click chemistry and use them for in vivo tumor imaging.Krzysztof P. BzymekJames W. PuckettCindy ZerJun XieYuelong MaJeremy D. KingLeah H. GoodsteinKendra N. AveryDavid ColcherGagandeep SinghDavid A. HorneJohn C. WilliamsNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Krzysztof P. Bzymek James W. Puckett Cindy Zer Jun Xie Yuelong Ma Jeremy D. King Leah H. Goodstein Kendra N. Avery David Colcher Gagandeep Singh David A. Horne John C. Williams Mechanically interlocked functionalization of monoclonal antibodies
description	Meditope-Fab is a peptide-antibody complex potentially useful for drug delivery and diagnostic, but a short half-life prevents its use in vivo. Here the authors engineer the complex to improve its stability, create functionalized antibodies by click chemistry and use them for in vivo tumor imaging.
format	article
author	Krzysztof P. Bzymek James W. Puckett Cindy Zer Jun Xie Yuelong Ma Jeremy D. King Leah H. Goodstein Kendra N. Avery David Colcher Gagandeep Singh David A. Horne John C. Williams
author_facet	Krzysztof P. Bzymek James W. Puckett Cindy Zer Jun Xie Yuelong Ma Jeremy D. King Leah H. Goodstein Kendra N. Avery David Colcher Gagandeep Singh David A. Horne John C. Williams
author_sort	Krzysztof P. Bzymek
title	Mechanically interlocked functionalization of monoclonal antibodies
title_short	Mechanically interlocked functionalization of monoclonal antibodies
title_full	Mechanically interlocked functionalization of monoclonal antibodies
title_fullStr	Mechanically interlocked functionalization of monoclonal antibodies
title_full_unstemmed	Mechanically interlocked functionalization of monoclonal antibodies
title_sort	mechanically interlocked functionalization of monoclonal antibodies
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9183f2a427c44a76a8fa504cd3b997a4
work_keys_str_mv	AT krzysztofpbzymek mechanicallyinterlockedfunctionalizationofmonoclonalantibodies AT jameswpuckett mechanicallyinterlockedfunctionalizationofmonoclonalantibodies AT cindyzer mechanicallyinterlockedfunctionalizationofmonoclonalantibodies AT junxie mechanicallyinterlockedfunctionalizationofmonoclonalantibodies AT yuelongma mechanicallyinterlockedfunctionalizationofmonoclonalantibodies AT jeremydking mechanicallyinterlockedfunctionalizationofmonoclonalantibodies AT leahhgoodstein mechanicallyinterlockedfunctionalizationofmonoclonalantibodies AT kendranavery mechanicallyinterlockedfunctionalizationofmonoclonalantibodies AT davidcolcher mechanicallyinterlockedfunctionalizationofmonoclonalantibodies AT gagandeepsingh mechanicallyinterlockedfunctionalizationofmonoclonalantibodies AT davidahorne mechanicallyinterlockedfunctionalizationofmonoclonalantibodies AT johncwilliams mechanicallyinterlockedfunctionalizationofmonoclonalantibodies
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Mechanically interlocked functionalization of monoclonal antibodies

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