A cell-free platform for the prenylation of natural products and application to cannabinoid production

Producing individual cannabinoids by metabolically engineered microbes has proven challenging. Here, the authors develop a cell-free enzymatic prenylating system to generate isoprenyl pyrophosphate substrates directly from glucose and produce both common and rare cannabinoids at >1 g/L.

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Autores principales:	Meaghan A. Valliere, Tyler P. Korman, Nicholas B. Woodall, Gregory A. Khitrov, Robert E. Taylor, David Baker, James U. Bowie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/91846144fed24fbd93ae5a96ab7c927a
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spelling	oai:doaj.org-article:91846144fed24fbd93ae5a96ab7c927a2021-12-02T14:39:38ZA cell-free platform for the prenylation of natural products and application to cannabinoid production10.1038/s41467-019-08448-y2041-1723https://doaj.org/article/91846144fed24fbd93ae5a96ab7c927a2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08448-yhttps://doaj.org/toc/2041-1723Producing individual cannabinoids by metabolically engineered microbes has proven challenging. Here, the authors develop a cell-free enzymatic prenylating system to generate isoprenyl pyrophosphate substrates directly from glucose and produce both common and rare cannabinoids at >1 g/L.Meaghan A. ValliereTyler P. KormanNicholas B. WoodallGregory A. KhitrovRobert E. TaylorDavid BakerJames U. BowieNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Meaghan A. Valliere Tyler P. Korman Nicholas B. Woodall Gregory A. Khitrov Robert E. Taylor David Baker James U. Bowie A cell-free platform for the prenylation of natural products and application to cannabinoid production
description	Producing individual cannabinoids by metabolically engineered microbes has proven challenging. Here, the authors develop a cell-free enzymatic prenylating system to generate isoprenyl pyrophosphate substrates directly from glucose and produce both common and rare cannabinoids at >1 g/L.
format	article
author	Meaghan A. Valliere Tyler P. Korman Nicholas B. Woodall Gregory A. Khitrov Robert E. Taylor David Baker James U. Bowie
author_facet	Meaghan A. Valliere Tyler P. Korman Nicholas B. Woodall Gregory A. Khitrov Robert E. Taylor David Baker James U. Bowie
author_sort	Meaghan A. Valliere
title	A cell-free platform for the prenylation of natural products and application to cannabinoid production
title_short	A cell-free platform for the prenylation of natural products and application to cannabinoid production
title_full	A cell-free platform for the prenylation of natural products and application to cannabinoid production
title_fullStr	A cell-free platform for the prenylation of natural products and application to cannabinoid production
title_full_unstemmed	A cell-free platform for the prenylation of natural products and application to cannabinoid production
title_sort	cell-free platform for the prenylation of natural products and application to cannabinoid production
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/91846144fed24fbd93ae5a96ab7c927a
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A cell-free platform for the prenylation of natural products and application to cannabinoid production

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