Exposures associated with the onset of Kawasaki disease in infancy from the Japan Environment and Children’s Study

Abstract Kawasaki disease (KD) is an acute systemic vasculitis that mainly affects infants and young children. The etiology of KD has been discussed for several decades; however, no reproducible risk factors have yet been proven. We used the Japan Environment and Children’s Study data to explore the...

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Autores principales:	Sayaka Fukuda, Shiro Tanaka, Chihiro Kawakami, Tohru Kobayashi, Shuichi Ito, the Japan Environment and Children’s Study (JECS) Group
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/918ad6f427244dcb925185da1cdd9f2d
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spelling	oai:doaj.org-article:918ad6f427244dcb925185da1cdd9f2d2021-12-02T17:45:12ZExposures associated with the onset of Kawasaki disease in infancy from the Japan Environment and Children’s Study10.1038/s41598-021-92669-z2045-2322https://doaj.org/article/918ad6f427244dcb925185da1cdd9f2d2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92669-zhttps://doaj.org/toc/2045-2322Abstract Kawasaki disease (KD) is an acute systemic vasculitis that mainly affects infants and young children. The etiology of KD has been discussed for several decades; however, no reproducible risk factors have yet been proven. We used the Japan Environment and Children’s Study data to explore the association between the causal effects of exposure during the fetal and neonatal periods and KD onset. The Japan Environment and Children’s Study, a nationwide birth cohort study, has followed approximately 100,000 children since 2011. We obtained data on exposures and outcomes from the first trimester to 12 months after birth. Finally, we included 90,486 children who were followed for 12 months. Among them, 343 children developed KD. Multivariate logistic regression revealed that insufficient intake of folic acid during pregnancy (odds ratio [OR], 1.37; 95% CI 1.08–1.74), maternal thyroid disease during pregnancy (OR, 2.03; 95% CI 1.04–3.94), and presence of siblings (OR, 1.33; 95% CI 1.06–1.67) were associated with KD onset in infancy. In this study, we identified three exposures as risk factors for KD. Further well-designed studies are needed to confirm a causal relationship between these exposures and KD onset.Sayaka FukudaShiro TanakaChihiro KawakamiTohru KobayashiShuichi Itothe Japan Environment and Children’s Study (JECS) GroupNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sayaka Fukuda Shiro Tanaka Chihiro Kawakami Tohru Kobayashi Shuichi Ito the Japan Environment and Children’s Study (JECS) Group Exposures associated with the onset of Kawasaki disease in infancy from the Japan Environment and Children’s Study
description	Abstract Kawasaki disease (KD) is an acute systemic vasculitis that mainly affects infants and young children. The etiology of KD has been discussed for several decades; however, no reproducible risk factors have yet been proven. We used the Japan Environment and Children’s Study data to explore the association between the causal effects of exposure during the fetal and neonatal periods and KD onset. The Japan Environment and Children’s Study, a nationwide birth cohort study, has followed approximately 100,000 children since 2011. We obtained data on exposures and outcomes from the first trimester to 12 months after birth. Finally, we included 90,486 children who were followed for 12 months. Among them, 343 children developed KD. Multivariate logistic regression revealed that insufficient intake of folic acid during pregnancy (odds ratio [OR], 1.37; 95% CI 1.08–1.74), maternal thyroid disease during pregnancy (OR, 2.03; 95% CI 1.04–3.94), and presence of siblings (OR, 1.33; 95% CI 1.06–1.67) were associated with KD onset in infancy. In this study, we identified three exposures as risk factors for KD. Further well-designed studies are needed to confirm a causal relationship between these exposures and KD onset.
format	article
author	Sayaka Fukuda Shiro Tanaka Chihiro Kawakami Tohru Kobayashi Shuichi Ito the Japan Environment and Children’s Study (JECS) Group
author_facet	Sayaka Fukuda Shiro Tanaka Chihiro Kawakami Tohru Kobayashi Shuichi Ito the Japan Environment and Children’s Study (JECS) Group
author_sort	Sayaka Fukuda
title	Exposures associated with the onset of Kawasaki disease in infancy from the Japan Environment and Children’s Study
title_short	Exposures associated with the onset of Kawasaki disease in infancy from the Japan Environment and Children’s Study
title_full	Exposures associated with the onset of Kawasaki disease in infancy from the Japan Environment and Children’s Study
title_fullStr	Exposures associated with the onset of Kawasaki disease in infancy from the Japan Environment and Children’s Study
title_full_unstemmed	Exposures associated with the onset of Kawasaki disease in infancy from the Japan Environment and Children’s Study
title_sort	exposures associated with the onset of kawasaki disease in infancy from the japan environment and children’s study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/918ad6f427244dcb925185da1cdd9f2d
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Exposures associated with the onset of Kawasaki disease in infancy from the Japan Environment and Children’s Study

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