Blending oxytocin and dopamine with everyday creativity

Abstract Converging evidence suggests that oxytocin (OT) is associated with creative thinking (CT) and that release of OT depends on ADP ribosyl-cyclases (CD38 and CD157). Neural mechanisms of CT and OT show a strong association with dopaminergic (DA) pathways, yet the link between CT and CD38, CD15...

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Autores principales:	Anne Chong, Serenella Tolomeo, Yue Xiong, Dario Angeles, Mike Cheung, Benjamin Becker, Poh San Lai, Zhen Lei, Fabio Malavasi, Qianzi Tang, Soo Hong Chew, Richard P. Ebstein
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/918e8fe0a3354e3f8787043805e3d29f
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spelling	oai:doaj.org-article:918e8fe0a3354e3f8787043805e3d29f2021-12-02T19:06:44ZBlending oxytocin and dopamine with everyday creativity10.1038/s41598-021-95724-x2045-2322https://doaj.org/article/918e8fe0a3354e3f8787043805e3d29f2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95724-xhttps://doaj.org/toc/2045-2322Abstract Converging evidence suggests that oxytocin (OT) is associated with creative thinking (CT) and that release of OT depends on ADP ribosyl-cyclases (CD38 and CD157). Neural mechanisms of CT and OT show a strong association with dopaminergic (DA) pathways, yet the link between CT and CD38, CD157, dopamine receptor D2 (DRD2) and catechol-O-methyltransferase (COMT) peripheral gene expression remain inconclusive, thus limiting our understanding of the neurobiology of CT. To address this issue, two principal domains of CT, divergent thinking (AUT), were assessed. In men, both AUT is associated with gene expression of CD38, CD157, and their interaction CD38 × CD157. There were no significant associations for DA expression (DRD2, COMT, DRD2 × COMT) on both CT measures. However, analysis of the interactions of OT and DA systems reveal significant interactions for AUT in men. The full model explained a sizable 39% of the variance in females for the total CT score. The current findings suggest that OT and DA gene expression contributed significantly to cognition and CT phenotype. This provides the first empirical foundation of a more refined understanding of the molecular landscape of CT.Anne ChongSerenella TolomeoYue XiongDario AngelesMike CheungBenjamin BeckerPoh San LaiZhen LeiFabio MalavasiQianzi TangSoo Hong ChewRichard P. EbsteinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anne Chong Serenella Tolomeo Yue Xiong Dario Angeles Mike Cheung Benjamin Becker Poh San Lai Zhen Lei Fabio Malavasi Qianzi Tang Soo Hong Chew Richard P. Ebstein Blending oxytocin and dopamine with everyday creativity
description	Abstract Converging evidence suggests that oxytocin (OT) is associated with creative thinking (CT) and that release of OT depends on ADP ribosyl-cyclases (CD38 and CD157). Neural mechanisms of CT and OT show a strong association with dopaminergic (DA) pathways, yet the link between CT and CD38, CD157, dopamine receptor D2 (DRD2) and catechol-O-methyltransferase (COMT) peripheral gene expression remain inconclusive, thus limiting our understanding of the neurobiology of CT. To address this issue, two principal domains of CT, divergent thinking (AUT), were assessed. In men, both AUT is associated with gene expression of CD38, CD157, and their interaction CD38 × CD157. There were no significant associations for DA expression (DRD2, COMT, DRD2 × COMT) on both CT measures. However, analysis of the interactions of OT and DA systems reveal significant interactions for AUT in men. The full model explained a sizable 39% of the variance in females for the total CT score. The current findings suggest that OT and DA gene expression contributed significantly to cognition and CT phenotype. This provides the first empirical foundation of a more refined understanding of the molecular landscape of CT.
format	article
author	Anne Chong Serenella Tolomeo Yue Xiong Dario Angeles Mike Cheung Benjamin Becker Poh San Lai Zhen Lei Fabio Malavasi Qianzi Tang Soo Hong Chew Richard P. Ebstein
author_facet	Anne Chong Serenella Tolomeo Yue Xiong Dario Angeles Mike Cheung Benjamin Becker Poh San Lai Zhen Lei Fabio Malavasi Qianzi Tang Soo Hong Chew Richard P. Ebstein
author_sort	Anne Chong
title	Blending oxytocin and dopamine with everyday creativity
title_short	Blending oxytocin and dopamine with everyday creativity
title_full	Blending oxytocin and dopamine with everyday creativity
title_fullStr	Blending oxytocin and dopamine with everyday creativity
title_full_unstemmed	Blending oxytocin and dopamine with everyday creativity
title_sort	blending oxytocin and dopamine with everyday creativity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/918e8fe0a3354e3f8787043805e3d29f
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Blending oxytocin and dopamine with everyday creativity

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