Elevated Serum Interleukin-34 Level in Patients with Systemic Lupus Erythematosus Is Associated with Disease Activity

Abstract We measured the interleukin-34 (IL-34) level in sera from patients with systemic lupus erythematosus (SLE) and discoid lupus erythematosus (DLE) using an enzyme-linked immunosorbent assay (ELISA). Blood tests, including assays to determine C-reactive protein (CRP), complement (C) 3, C4, imm...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Huan Huan Xie, Hui Shen, Li Zhang, Mei Ying Cui, Li Ping Xia, Jing Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9191ade8e9d349758bc8829ac49c8670
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9191ade8e9d349758bc8829ac49c8670
record_format	dspace
spelling	oai:doaj.org-article:9191ade8e9d349758bc8829ac49c86702021-12-02T11:40:17ZElevated Serum Interleukin-34 Level in Patients with Systemic Lupus Erythematosus Is Associated with Disease Activity10.1038/s41598-018-21859-z2045-2322https://doaj.org/article/9191ade8e9d349758bc8829ac49c86702018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-21859-zhttps://doaj.org/toc/2045-2322Abstract We measured the interleukin-34 (IL-34) level in sera from patients with systemic lupus erythematosus (SLE) and discoid lupus erythematosus (DLE) using an enzyme-linked immunosorbent assay (ELISA). Blood tests, including assays to determine C-reactive protein (CRP), complement (C) 3, C4, immunoglobulin (Ig) A, IgG, IgM, anti-double-stranded DNA antibody (Anti-dsDNA Ab) and hemoglobin (Hb) levels and white blood cell (WBC) and platelet (PLT) counts, were performed using standard methods. Lupus nephritis (LN) was diagnosed according to the American College of Rheumatology (ACR) renal criteria. The SLE disease activity was scored using the SLE Disease Activity Index (SLEDAI). Among the 110 SLE cases, IL-34 could be detected in 79 cases (71.8%). IL-34 was barely detected in the control group. The serum level of IL-34 was significantly higher in the SLE group. No change was observed in the serum IL-34 concentration in the SLE patients regardless of LN status. Correlations were observed between the serum IL-34 level and the disease activity parameters. The SLE patients with detectable IL-34 levels had higher SLEDAI and IgG concentrations and lower C3 and Hb levels than patients with undetectable IL-34 levels. Therefore, IL-34 could be a potential disease activity marker for SLE.Huan Huan XieHui ShenLi ZhangMei Ying CuiLi Ping XiaJing LuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-6 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Huan Huan Xie Hui Shen Li Zhang Mei Ying Cui Li Ping Xia Jing Lu Elevated Serum Interleukin-34 Level in Patients with Systemic Lupus Erythematosus Is Associated with Disease Activity
description	Abstract We measured the interleukin-34 (IL-34) level in sera from patients with systemic lupus erythematosus (SLE) and discoid lupus erythematosus (DLE) using an enzyme-linked immunosorbent assay (ELISA). Blood tests, including assays to determine C-reactive protein (CRP), complement (C) 3, C4, immunoglobulin (Ig) A, IgG, IgM, anti-double-stranded DNA antibody (Anti-dsDNA Ab) and hemoglobin (Hb) levels and white blood cell (WBC) and platelet (PLT) counts, were performed using standard methods. Lupus nephritis (LN) was diagnosed according to the American College of Rheumatology (ACR) renal criteria. The SLE disease activity was scored using the SLE Disease Activity Index (SLEDAI). Among the 110 SLE cases, IL-34 could be detected in 79 cases (71.8%). IL-34 was barely detected in the control group. The serum level of IL-34 was significantly higher in the SLE group. No change was observed in the serum IL-34 concentration in the SLE patients regardless of LN status. Correlations were observed between the serum IL-34 level and the disease activity parameters. The SLE patients with detectable IL-34 levels had higher SLEDAI and IgG concentrations and lower C3 and Hb levels than patients with undetectable IL-34 levels. Therefore, IL-34 could be a potential disease activity marker for SLE.
format	article
author	Huan Huan Xie Hui Shen Li Zhang Mei Ying Cui Li Ping Xia Jing Lu
author_facet	Huan Huan Xie Hui Shen Li Zhang Mei Ying Cui Li Ping Xia Jing Lu
author_sort	Huan Huan Xie
title	Elevated Serum Interleukin-34 Level in Patients with Systemic Lupus Erythematosus Is Associated with Disease Activity
title_short	Elevated Serum Interleukin-34 Level in Patients with Systemic Lupus Erythematosus Is Associated with Disease Activity
title_full	Elevated Serum Interleukin-34 Level in Patients with Systemic Lupus Erythematosus Is Associated with Disease Activity
title_fullStr	Elevated Serum Interleukin-34 Level in Patients with Systemic Lupus Erythematosus Is Associated with Disease Activity
title_full_unstemmed	Elevated Serum Interleukin-34 Level in Patients with Systemic Lupus Erythematosus Is Associated with Disease Activity
title_sort	elevated serum interleukin-34 level in patients with systemic lupus erythematosus is associated with disease activity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9191ade8e9d349758bc8829ac49c8670
work_keys_str_mv	AT huanhuanxie elevatedseruminterleukin34levelinpatientswithsystemiclupuserythematosusisassociatedwithdiseaseactivity AT huishen elevatedseruminterleukin34levelinpatientswithsystemiclupuserythematosusisassociatedwithdiseaseactivity AT lizhang elevatedseruminterleukin34levelinpatientswithsystemiclupuserythematosusisassociatedwithdiseaseactivity AT meiyingcui elevatedseruminterleukin34levelinpatientswithsystemiclupuserythematosusisassociatedwithdiseaseactivity AT lipingxia elevatedseruminterleukin34levelinpatientswithsystemiclupuserythematosusisassociatedwithdiseaseactivity AT jinglu elevatedseruminterleukin34levelinpatientswithsystemiclupuserythematosusisassociatedwithdiseaseactivity
_version_	1718395658925244416

Elevated Serum Interleukin-34 Level in Patients with Systemic Lupus Erythematosus Is Associated with Disease Activity

Ejemplares similares