Nanomedicine for the reduction of the thrombogenicity of stent coatings

Varvara C Karagkiozaki1,2, Stergios D Logothetidis2, Spyridon N Kassavetis2, George D Giannoglou11Aristotle University of Thessaloniki, Medical School, AHE PA University General Hospital, 1st Cardiology Department, Cardiovascular Engineering and Atherosclerosis Laboratory, Greece; 2Aristotle Univers...

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Autores principales:	Varvara C Karagkiozaki, Stergios D Logothetidis, Spyridon N Kassavetis, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/919700c9eeb345a4b5a7f6f2754d049f
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spelling	oai:doaj.org-article:919700c9eeb345a4b5a7f6f2754d049f2021-12-02T06:38:06ZNanomedicine for the reduction of the thrombogenicity of stent coatings1176-91141178-2013https://doaj.org/article/919700c9eeb345a4b5a7f6f2754d049f2010-03-01T00:00:00Zhttp://www.dovepress.com/nanomedicine-for-the-reduction-of-the-thrombogenicity-of-stent-coating-a4150https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Varvara C Karagkiozaki1,2, Stergios D Logothetidis2, Spyridon N Kassavetis2, George D Giannoglou11Aristotle University of Thessaloniki, Medical School, AHE PA University General Hospital, 1st Cardiology Department, Cardiovascular Engineering and Atherosclerosis Laboratory, Greece; 2Aristotle University of Thessaloniki, Physics Department, Laboratory for Thin Films &ndash; Nanosystems and Nanometrology (LTFN), GreeceAbstract: The treatment of patients with drug-eluting stents (DES) continues to evolve with the current emergence of DES technology that offers a combination of pharmacological and mechanical approaches to prevent arterial restenosis. However, despite the promising short-term and mid-term outcomes of DES, there are valid concerns about adverse clinical effects of late stent thrombosis. In this study, we present an example of how nanomedicine can offer solutions for improving stent coating manufacturing, by producing nanomaterials with tailored and controllable properties. The study is based on the exploitation of human platelets response towards carbon-based nanocoatings via atomic force microscope (AFM). AFM can facilitate the comprehensive analysis of platelets behavior onto stent nanocoatings and enable the study of thrombogenicity. Platelet-rich plasma from healthy donors was used for the real-time study of biointerfacial interactions. The carbon nanomaterials were developed by rf magnetron sputtering technique under controllable deposition conditions to provide favorable surface nanotopography. It was shown that by altering the surface topography of nanocoatings, the activation of platelets can be affected, while the carbon nanocoatings having higher surface roughness were found to be less thrombogenic in terms of platelets adhesion. This is an actual solution for improving the stent coating fabrication.Keywords: stents nanomedicine, carbon coating, atomic force microscopy platelets nanotechnology Varvara C KaragkiozakiStergios D LogothetidisSpyridon N Kassavetiset alDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2010, Iss default, Pp 239-248 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Varvara C Karagkiozaki Stergios D Logothetidis Spyridon N Kassavetis et al Nanomedicine for the reduction of the thrombogenicity of stent coatings
description	Varvara C Karagkiozaki1,2, Stergios D Logothetidis2, Spyridon N Kassavetis2, George D Giannoglou11Aristotle University of Thessaloniki, Medical School, AHE PA University General Hospital, 1st Cardiology Department, Cardiovascular Engineering and Atherosclerosis Laboratory, Greece; 2Aristotle University of Thessaloniki, Physics Department, Laboratory for Thin Films &ndash; Nanosystems and Nanometrology (LTFN), GreeceAbstract: The treatment of patients with drug-eluting stents (DES) continues to evolve with the current emergence of DES technology that offers a combination of pharmacological and mechanical approaches to prevent arterial restenosis. However, despite the promising short-term and mid-term outcomes of DES, there are valid concerns about adverse clinical effects of late stent thrombosis. In this study, we present an example of how nanomedicine can offer solutions for improving stent coating manufacturing, by producing nanomaterials with tailored and controllable properties. The study is based on the exploitation of human platelets response towards carbon-based nanocoatings via atomic force microscope (AFM). AFM can facilitate the comprehensive analysis of platelets behavior onto stent nanocoatings and enable the study of thrombogenicity. Platelet-rich plasma from healthy donors was used for the real-time study of biointerfacial interactions. The carbon nanomaterials were developed by rf magnetron sputtering technique under controllable deposition conditions to provide favorable surface nanotopography. It was shown that by altering the surface topography of nanocoatings, the activation of platelets can be affected, while the carbon nanocoatings having higher surface roughness were found to be less thrombogenic in terms of platelets adhesion. This is an actual solution for improving the stent coating fabrication.Keywords: stents nanomedicine, carbon coating, atomic force microscopy platelets nanotechnology
format	article
author	Varvara C Karagkiozaki Stergios D Logothetidis Spyridon N Kassavetis et al
author_facet	Varvara C Karagkiozaki Stergios D Logothetidis Spyridon N Kassavetis et al
author_sort	Varvara C Karagkiozaki
title	Nanomedicine for the reduction of the thrombogenicity of stent coatings
title_short	Nanomedicine for the reduction of the thrombogenicity of stent coatings
title_full	Nanomedicine for the reduction of the thrombogenicity of stent coatings
title_fullStr	Nanomedicine for the reduction of the thrombogenicity of stent coatings
title_full_unstemmed	Nanomedicine for the reduction of the thrombogenicity of stent coatings
title_sort	nanomedicine for the reduction of the thrombogenicity of stent coatings
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/919700c9eeb345a4b5a7f6f2754d049f
work_keys_str_mv	AT varvarackaragkiozaki nanomedicineforthereductionofthethrombogenicityofstentcoatings AT stergiosdlogothetidis nanomedicineforthereductionofthethrombogenicityofstentcoatings AT spyridonnkassavetis nanomedicineforthereductionofthethrombogenicityofstentcoatings AT etal nanomedicineforthereductionofthethrombogenicityofstentcoatings
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Nanomedicine for the reduction of the thrombogenicity of stent coatings

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