Concerted regulation of retinal pigment epithelium basement membrane and barrier function by angiocrine factors

Establishment of the outer blood-retina barrier is a hallmark of retinal development but the contribution of choroid endothelial cells (ECs) is not known. Here the authors show in the developing mouse retina that ECs remodel the basement membrane and lead to enhanced barrier function of retinal epit...

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Autores principales: Ignacio Benedicto, Guillermo L. Lehmann, Michael Ginsberg, Daniel J. Nolan, Rohan Bareja, Olivier Elemento, Zelda Salfati, Nazia M. Alam, Glen T. Prusky, Pierre Llanos, Sina Y. Rabbany, Arvydas Maminishkis, Sheldon S. Miller, Shahin Rafii, Enrique Rodriguez-Boulan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/919b83179e8542b08aff5bc2e85e591a
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Sumario:Establishment of the outer blood-retina barrier is a hallmark of retinal development but the contribution of choroid endothelial cells (ECs) is not known. Here the authors show in the developing mouse retina that ECs remodel the basement membrane and lead to enhanced barrier function of retinal epithelial cells.